Data from: Genome-wide support for incipient Tula orthohantavirus species within a single rodent host lineage
Evolutionary divergence of viruses is most commonly driven by co-divergence with their hosts or through isolation of transmission after host-shifts. It remains mostly unknown, however, whether divergent phylogenetic clades within named virus species represent functionally equivalent byproducts of hi...
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ftzenodo:oai:zenodo.org:10496394 2024-09-15T18:02:50+00:00 Data from: Genome-wide support for incipient Tula orthohantavirus species within a single rodent host lineage Labutin, Anton Heckel, Gerald 2024-01-12 https://doi.org/10.5061/dryad.w0vt4b905 unknown Zenodo https://zenodo.org/communities/dryad https://doi.org/10.5061/dryad.w0vt4b905 oai:zenodo.org:10496394 info:eu-repo/semantics/openAccess Creative Commons Zero v1.0 Universal https://creativecommons.org/publicdomain/zero/1.0/legalcode Genome-wide association studies genomic admixture Host-pathogen co-evolution Microtus arvalis Tula orthohantavirus virus speciation RNA virus Hantavirus info:eu-repo/semantics/other 2024 ftzenodo https://doi.org/10.5061/dryad.w0vt4b905 2024-07-25T09:58:27Z Evolutionary divergence of viruses is most commonly driven by co-divergence with their hosts or through isolation of transmission after host-shifts. It remains mostly unknown, however, whether divergent phylogenetic clades within named virus species represent functionally equivalent byproducts of high evolutionary rates or rather incipient virus species. Here, we test these alternatives with genomic data from two widespread phylogenetic clades in Tula orthohantavirus (TULV) within a single evolutionary lineage of their natural rodent host, the common vole Microtus arvalis. We examined voles from 42 locations in the contact region between clades for TULV infection by RT-PCR. Sequencing yielded 23 TULV Central North and 21 TULV Central South genomes which differed by 14.9-18.5% at the nucleotide and 2.2-3.7% at the amino acid level without evidence of recombination or reassortment. Geographic cline analyses demonstrated an abrupt (<1 km wide) transition between the parapatric TULV clades in continuous landscape. This transition was located within the Central mitochondrial lineage of M. arvalis and genomic SNPs showed gradual mixing of host populations across it. Genomic differentiation of hosts was much weaker across the TULV Central North to South transition than across the nearby hybrid zone between two evolutionary lineages in the host. We suggest that these parapatric TULV clades represent functionally distinct, incipient species which are likely differently affected by genetic polymorphisms in the host. This highlights the potential of natural viral contact zones as systems for investigating of the genetic and evolutionary factors enabling or restricting the transmission of RNA viruses. Funding provided by: Swiss National Science Foundation Crossref Funder Registry ID: https://ror.org/00yjd3n13 Award Number: 31003A_176209 Genotyping of host nuclear DNA Genome-wide nuclear DNA (nucDNA) was used to infer the genetic structure of hosts via Genotyping by Sequencing (GBS) (Elshire et al., 2011). We ... Other/Unknown Material Common vole Microtus arvalis Zenodo |
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Genome-wide association studies genomic admixture Host-pathogen co-evolution Microtus arvalis Tula orthohantavirus virus speciation RNA virus Hantavirus |
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Genome-wide association studies genomic admixture Host-pathogen co-evolution Microtus arvalis Tula orthohantavirus virus speciation RNA virus Hantavirus Labutin, Anton Heckel, Gerald Data from: Genome-wide support for incipient Tula orthohantavirus species within a single rodent host lineage |
topic_facet |
Genome-wide association studies genomic admixture Host-pathogen co-evolution Microtus arvalis Tula orthohantavirus virus speciation RNA virus Hantavirus |
description |
Evolutionary divergence of viruses is most commonly driven by co-divergence with their hosts or through isolation of transmission after host-shifts. It remains mostly unknown, however, whether divergent phylogenetic clades within named virus species represent functionally equivalent byproducts of high evolutionary rates or rather incipient virus species. Here, we test these alternatives with genomic data from two widespread phylogenetic clades in Tula orthohantavirus (TULV) within a single evolutionary lineage of their natural rodent host, the common vole Microtus arvalis. We examined voles from 42 locations in the contact region between clades for TULV infection by RT-PCR. Sequencing yielded 23 TULV Central North and 21 TULV Central South genomes which differed by 14.9-18.5% at the nucleotide and 2.2-3.7% at the amino acid level without evidence of recombination or reassortment. Geographic cline analyses demonstrated an abrupt (<1 km wide) transition between the parapatric TULV clades in continuous landscape. This transition was located within the Central mitochondrial lineage of M. arvalis and genomic SNPs showed gradual mixing of host populations across it. Genomic differentiation of hosts was much weaker across the TULV Central North to South transition than across the nearby hybrid zone between two evolutionary lineages in the host. We suggest that these parapatric TULV clades represent functionally distinct, incipient species which are likely differently affected by genetic polymorphisms in the host. This highlights the potential of natural viral contact zones as systems for investigating of the genetic and evolutionary factors enabling or restricting the transmission of RNA viruses. Funding provided by: Swiss National Science Foundation Crossref Funder Registry ID: https://ror.org/00yjd3n13 Award Number: 31003A_176209 Genotyping of host nuclear DNA Genome-wide nuclear DNA (nucDNA) was used to infer the genetic structure of hosts via Genotyping by Sequencing (GBS) (Elshire et al., 2011). We ... |
format |
Other/Unknown Material |
author |
Labutin, Anton Heckel, Gerald |
author_facet |
Labutin, Anton Heckel, Gerald |
author_sort |
Labutin, Anton |
title |
Data from: Genome-wide support for incipient Tula orthohantavirus species within a single rodent host lineage |
title_short |
Data from: Genome-wide support for incipient Tula orthohantavirus species within a single rodent host lineage |
title_full |
Data from: Genome-wide support for incipient Tula orthohantavirus species within a single rodent host lineage |
title_fullStr |
Data from: Genome-wide support for incipient Tula orthohantavirus species within a single rodent host lineage |
title_full_unstemmed |
Data from: Genome-wide support for incipient Tula orthohantavirus species within a single rodent host lineage |
title_sort |
data from: genome-wide support for incipient tula orthohantavirus species within a single rodent host lineage |
publisher |
Zenodo |
publishDate |
2024 |
url |
https://doi.org/10.5061/dryad.w0vt4b905 |
genre |
Common vole Microtus arvalis |
genre_facet |
Common vole Microtus arvalis |
op_relation |
https://zenodo.org/communities/dryad https://doi.org/10.5061/dryad.w0vt4b905 oai:zenodo.org:10496394 |
op_rights |
info:eu-repo/semantics/openAccess Creative Commons Zero v1.0 Universal https://creativecommons.org/publicdomain/zero/1.0/legalcode |
op_doi |
https://doi.org/10.5061/dryad.w0vt4b905 |
_version_ |
1810440241209671680 |