CanineHD 230 K BeadChip data from Pembroke Welsh corgi

• Main Author: Matsumoto, Yuki
• Format: Other/Unknown Material
• Language: unknown
• Published: Zenodo 2023
• Subjects: Canis lupus familiaris; domestic dog; BeadChip; SNP array; Canis lupus
• Online Access: https://doi.org/10.5061/dryad.rbnzs7hhk

Several hundred disease-causing mutations are currently known in domestic dogs. Breeding management is therefore required to minimize their spread. Recently, genetic methods such as direct-to-consumer testing have gained popularity; however, their effects on dog populations are unclear. Here, we aimed to evaluate the influence of genetic testing on the frequency of mutations responsible for canine degenerative myelopathy (DM) and assess the changes in the genetic structure of a Pembroke Welsh corgi population from Japan. To evaluate the influence of genetic testing on the frequency of mutations causing canine degenerative myelopathy and changes to genetic structure in the Pembroke Welsh corgi population from Japan, 117 dogs were genotyped. Weir and Cockerham population differentiation (FST) based on genome-wide single-nucleotide polymorphism (SNP) detected the SNP with the highest FST located in the intron of SOD1 adjacent to the c.118G>A mutation, supporting a selection signature on SOD1. Further genome-wide SNP analyses revealed no obvious changes in inbreeding levels between the 2019 and 2022 populations. Our study highlights that genetic testing can help inform improved mating choices in breeding programs to reduce the frequency of risk variants and avoid inbreeding. Funding provided by: Anicom Specialty Medical Institute Inc.* Crossref Funder Registry ID: Award Number: 142,510 single nucleotide polymorphism (SNP) of 112 dogs by using Illumina's Canine 230K Consortium chip.