Multiple types of genomic variation contribute to adaptive traits in the mustelid subfamily Guloninae

Species of the mustelid subfamily Guloninae inhabit diverse habitats on multiple continents, and occupy a variety of ecological niches. They differ in feeding ecologies, reproductive strategies and morphological adaptations. To identify candidate loci associated with adaptations to their respective...

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Published in:Molecular Ecology
Main Authors: Derežanin, Lorena, Blažytė, Asta, Dobrynin, Pavel, Duchêne, David A., Grau, José Horacio, Jeon, Sungwon, Kliver, Sergei, Koepfli, Klaus‐Peter, Meneghini, Dorina, Preick, Michaela, Tomarovsky, Andrey, Totikov, Azamat, Fickel, Jörns, Förster, Daniel W.
Format: Article in Journal/Newspaper
Language:English
Published: 2022
Subjects:
Online Access:https://repository.publisso.de/resource/frl:6449376
https://doi.org/10.1111/mec.16443
https://onlinelibrary.wiley.com/doi/10.1111/mec.16443#support-information-section
id ftzbmed:oai:frl.publisso.de:frl:6449376
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spelling ftzbmed:oai:frl.publisso.de:frl:6449376 2023-10-09T21:52:07+02:00 Multiple types of genomic variation contribute to adaptive traits in the mustelid subfamily Guloninae Derežanin, Lorena Blažytė, Asta Dobrynin, Pavel Duchêne, David A. Grau, José Horacio Jeon, Sungwon Kliver, Sergei Koepfli, Klaus‐Peter Meneghini, Dorina Preick, Michaela Tomarovsky, Andrey Totikov, Azamat Fickel, Jörns Förster, Daniel W. 2022 https://repository.publisso.de/resource/frl:6449376 https://doi.org/10.1111/mec.16443 https://onlinelibrary.wiley.com/doi/10.1111/mec.16443#support-information-section eng eng https://repository.publisso.de/resource/frl:6449376 https://doi.org/10.1111/mec.16443 https://onlinelibrary.wiley.com/doi/10.1111/mec.16443#support-information-section http://creativecommons.org/licenses/by-nc/4.0/ http://lobid.org/resources/99370671020506441#!, 31(10):2898-2919 structural variation Adaptation Physiological/genetics [MeSH] Genome [MeSH] gene family evolution Animals [MeSH] genomics Genomics [MeSH] Genetics positive selection Ecology Evolution Behavior and Systematics Mustelidae/genetics [MeSH] Phenotype [MeSH] mustelids Zeitschriftenartikel 2022 ftzbmed https://doi.org/10.1111/mec.16443 2023-09-10T22:09:05Z Species of the mustelid subfamily Guloninae inhabit diverse habitats on multiple continents, and occupy a variety of ecological niches. They differ in feeding ecologies, reproductive strategies and morphological adaptations. To identify candidate loci associated with adaptations to their respective environments, we generated a de novo assembly of the tayra (Eira barbara), the earliest diverging species in the subfamily, and compared this with the genomes available for the wolverine (Gulo gulo) and the sable (Martes zibellina). Our comparative genomic analyses included searching for signs of positive selection, examining changes in gene family sizes and searching for species-specific structural variants. Among candidate loci associated with phenotypic traits, we observed many related to diet, body condition and reproduction. For example, for the tayra, which has an atypical gulonine reproductive strategy of aseasonal breeding, we observed species-specific changes in many pregnancy-related genes. For the wolverine, a circumpolar hypercarnivore that must cope with seasonal food scarcity, we observed many changes in genes associated with diet and body condition. All types of genomic variation examined (single nucleotide polymorphisms, gene family expansions, structural variants) contributed substantially to the identification of candidate loci. This argues strongly for consideration of variation other than single nucleotide polymorphisms in comparative genomics studies aiming to identify loci of adaptive significance. Article in Journal/Newspaper Gulo gulo PUBLISSO Fachrepositorium Lebenswissenschaften (ZB MED) Eira ENVELOPE(8.132,8.132,62.685,62.685) Molecular Ecology 31 10 2898 2919
institution Open Polar
collection PUBLISSO Fachrepositorium Lebenswissenschaften (ZB MED)
op_collection_id ftzbmed
language English
topic structural variation
Adaptation
Physiological/genetics [MeSH]
Genome [MeSH]
gene family evolution
Animals [MeSH]
genomics
Genomics [MeSH]
Genetics
positive selection
Ecology
Evolution
Behavior and Systematics
Mustelidae/genetics [MeSH]
Phenotype [MeSH]
mustelids
spellingShingle structural variation
Adaptation
Physiological/genetics [MeSH]
Genome [MeSH]
gene family evolution
Animals [MeSH]
genomics
Genomics [MeSH]
Genetics
positive selection
Ecology
Evolution
Behavior and Systematics
Mustelidae/genetics [MeSH]
Phenotype [MeSH]
mustelids
Derežanin, Lorena
Blažytė, Asta
Dobrynin, Pavel
Duchêne, David A.
Grau, José Horacio
Jeon, Sungwon
Kliver, Sergei
Koepfli, Klaus‐Peter
Meneghini, Dorina
Preick, Michaela
Tomarovsky, Andrey
Totikov, Azamat
Fickel, Jörns
Förster, Daniel W.
Multiple types of genomic variation contribute to adaptive traits in the mustelid subfamily Guloninae
topic_facet structural variation
Adaptation
Physiological/genetics [MeSH]
Genome [MeSH]
gene family evolution
Animals [MeSH]
genomics
Genomics [MeSH]
Genetics
positive selection
Ecology
Evolution
Behavior and Systematics
Mustelidae/genetics [MeSH]
Phenotype [MeSH]
mustelids
description Species of the mustelid subfamily Guloninae inhabit diverse habitats on multiple continents, and occupy a variety of ecological niches. They differ in feeding ecologies, reproductive strategies and morphological adaptations. To identify candidate loci associated with adaptations to their respective environments, we generated a de novo assembly of the tayra (Eira barbara), the earliest diverging species in the subfamily, and compared this with the genomes available for the wolverine (Gulo gulo) and the sable (Martes zibellina). Our comparative genomic analyses included searching for signs of positive selection, examining changes in gene family sizes and searching for species-specific structural variants. Among candidate loci associated with phenotypic traits, we observed many related to diet, body condition and reproduction. For example, for the tayra, which has an atypical gulonine reproductive strategy of aseasonal breeding, we observed species-specific changes in many pregnancy-related genes. For the wolverine, a circumpolar hypercarnivore that must cope with seasonal food scarcity, we observed many changes in genes associated with diet and body condition. All types of genomic variation examined (single nucleotide polymorphisms, gene family expansions, structural variants) contributed substantially to the identification of candidate loci. This argues strongly for consideration of variation other than single nucleotide polymorphisms in comparative genomics studies aiming to identify loci of adaptive significance.
format Article in Journal/Newspaper
author Derežanin, Lorena
Blažytė, Asta
Dobrynin, Pavel
Duchêne, David A.
Grau, José Horacio
Jeon, Sungwon
Kliver, Sergei
Koepfli, Klaus‐Peter
Meneghini, Dorina
Preick, Michaela
Tomarovsky, Andrey
Totikov, Azamat
Fickel, Jörns
Förster, Daniel W.
author_facet Derežanin, Lorena
Blažytė, Asta
Dobrynin, Pavel
Duchêne, David A.
Grau, José Horacio
Jeon, Sungwon
Kliver, Sergei
Koepfli, Klaus‐Peter
Meneghini, Dorina
Preick, Michaela
Tomarovsky, Andrey
Totikov, Azamat
Fickel, Jörns
Förster, Daniel W.
author_sort Derežanin, Lorena
title Multiple types of genomic variation contribute to adaptive traits in the mustelid subfamily Guloninae
title_short Multiple types of genomic variation contribute to adaptive traits in the mustelid subfamily Guloninae
title_full Multiple types of genomic variation contribute to adaptive traits in the mustelid subfamily Guloninae
title_fullStr Multiple types of genomic variation contribute to adaptive traits in the mustelid subfamily Guloninae
title_full_unstemmed Multiple types of genomic variation contribute to adaptive traits in the mustelid subfamily Guloninae
title_sort multiple types of genomic variation contribute to adaptive traits in the mustelid subfamily guloninae
publishDate 2022
url https://repository.publisso.de/resource/frl:6449376
https://doi.org/10.1111/mec.16443
https://onlinelibrary.wiley.com/doi/10.1111/mec.16443#support-information-section
long_lat ENVELOPE(8.132,8.132,62.685,62.685)
geographic Eira
geographic_facet Eira
genre Gulo gulo
genre_facet Gulo gulo
op_source http://lobid.org/resources/99370671020506441#!, 31(10):2898-2919
op_relation https://repository.publisso.de/resource/frl:6449376
https://doi.org/10.1111/mec.16443
https://onlinelibrary.wiley.com/doi/10.1111/mec.16443#support-information-section
op_rights http://creativecommons.org/licenses/by-nc/4.0/
op_doi https://doi.org/10.1111/mec.16443
container_title Molecular Ecology
container_volume 31
container_issue 10
container_start_page 2898
op_container_end_page 2919
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