Timing of extracorporeal shock wave therapy in rabbits with carpal tunnel syndrome

• Published in: Journal of Tissue Engineering and Regenerative Medicine
• Other Authors: Gi�륻oung Park, Dong Rak Kwon, Sang Chul Lee, Lee, Sang Chul
• Format: Article in Journal/Newspaper
• Language: English
• Published: John Wiley & Sons 2019
• Subjects: carpal혻tunnel혻syndrome; 혻extracorporeal혻shock혻wave혻therapy; injection; median nerve; rabbit; New Zealand; DML
• Online Access: https://ir.ymlib.yonsei.ac.kr/handle/22282913/170326; https://doi.org/10.1002/term.2862; https://onlinelibrary.wiley.com/doi/full/10.1002/term.2862

The purpose of this study is to evaluate the effect of혻extracorporeal혻shock혻wave혻therapy(ESWT) according to treatment혻timing혻in혻rabbits혻with 10% dextrose-induced혻carpal혻tunnelsyndrome혻(CTS); 0.1-ml 10% dextrose solution was injected under ultrasound guidance twice weekly to the left forepaw subsynovial connective tissue (SSCT) within the혻carpal혻tunnel혻of 36 New Zealand white혻rabbits혻to induce CTS. The혻rabbits혻were randomly allocated into four groups: G1-S (sham ESWT), G2-E4 (ESWT at 4혻weeks), G3-E8 (at 8혻weeks), and G4-E16 (at 16혻weeks). Radial ESWT (500 pulses, 0.08혻mJ/mm2혻, 2혻Hz) was repeated thrice weekly. Median nerve distal motor latency (DML) was measured before injection and at 4, 8, 12, 16, and 20혻weeks after the first injection. All혻rabbits혻were sacrificed 20혻weeks after injection. The median nerve cross-sectional area (CSA) and SSCT thickness were measured with light microscopy. The mean median nerve DML at 4혻weeks after the first dextrose injection did not differ from that at preinjection in all groups. The mean median nerve DML significantly increased before ESWT in all groups (p혻<혻.05); however, it did not increase in G2-E4 and G3-E8 for 12혻weeks after ESWT and in G4-E16 for 4혻weeks (p혻>혻.05). Mean CSA of the median nerve and mean SSCT thickness in G2-E4 were significantly lower than those in the other groups (p혻<혻.05). ESWT may prevent the progression of CTS for 12혻weeks in혻rabbits혻with dextrose-induced CTS regardless of treatment혻timing, and early application results in superior outcomes. restriction