Study on the In Vitro Effects of the Mixtures of Polycyclic Aromatic Hydrocarbons (PAHs) and Heavy Metals on Ethoxyresorufin-O-Deethylase (EROD) Activity in Mossambica tilapia Liver

National Public Benefit (Ocean) Research Foundation of China [201105013]; Grand Research Foundation of Fujian Province [2011YZ0001-1, 2013J01386]; Scientific Research Foundation of Third Institute of Oceanography, SOA [201221] This paper reports in vitro effects of individual heavy metals (Cd2+, Cu2...

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Bibliographic Details
Main Authors: Han, Da Xiong, Wang, Hai Yan, Yue, Hong Wei, Wang, Su Min, 韩大雄
Format: Article in Journal/Newspaper
Language:English
Published: SPRINGER 2013
Subjects:
ANGUILLA-ANGUILLA L
DAB LIMANDA-LIMANDA
LEAPING MULLET
INHIBITION
RESPONSES
Anguilla anguilla
Online Access:http://dspace.xmu.edu.cn/handle/2288/93485
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Summary:National Public Benefit (Ocean) Research Foundation of China [201105013]; Grand Research Foundation of Fujian Province [2011YZ0001-1, 2013J01386]; Scientific Research Foundation of Third Institute of Oceanography, SOA [201221] This paper reports in vitro effects of individual heavy metals (Cd2+, Cu2+ and Hg2+), and PAHs, including benzo[a]pyrene(BaP), indeno[1,2,3-cd]pyrene (IP) and fluoranthene (FL), and their mixtures on ethoxyresorufin-O-deethylase (EROD) activities using a plate-reader method. The results showed that all three metals inhibited EROD activity, while BaP/IP significantly induced the enzyme. However, FL alone decreased EROD activity. Moreover, co-treatment with BaP/IP and heavy metals inhibited PAH-induced EROD activities, while combined exposure to FL and heavy metals induced FL-inhibited EROD activities.

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