Tissue Distribution of Polychlorinated Biphenyls and Organochlorine Pesticides and Potential Toxicity to Alaskan Northern Fur Seals Assessed Using PCBs Congener Specific Mode of Action Schemes
The fur seal (Callorhinus ursinus) population has decreased in their primary breeding grounds in the Bering Sea; contamination is among suspected causes. Our goal was to better understand the extent of contamination of seal tissues with certain organochlorine compounds by measuring the concentration...
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ftxiamenuniv:oai:dspace.xmu.edu.cn:2288/60586 2023-05-15T15:44:01+02:00 Tissue Distribution of Polychlorinated Biphenyls and Organochlorine Pesticides and Potential Toxicity to Alaskan Northern Fur Seals Assessed Using PCBs Congener Specific Mode of Action Schemes Wang, D. L. Shelver, W. L. Atkinson, S. Mellish, J. A. Li, Q. X. 王德利 2010 http://dspace.xmu.edu.cn/handle/2288/60586 en_US eng Archives of Environmental Contamination and Toxicology,58(2):478-488 0090-4341 ISI:000274314100023 http://dspace.xmu.edu.cn/handle/2288/60586 PERSISTENT ORGANIC POLLUTANTS CALLORHINUS-URSINUS REFERENCE VALUES PHOCA-VITULINA HUMAN BLOOD CONTAMINATION MIXTURES MILK SEQUESTRATION NEUROTOXICITY Article 2010 ftxiamenuniv 2020-07-21T11:32:12Z The fur seal (Callorhinus ursinus) population has decreased in their primary breeding grounds in the Bering Sea; contamination is among suspected causes. Our goal was to better understand the extent of contamination of seal tissues with certain organochlorine compounds by measuring the concentrations of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in fur seal tissues from St. Paul Island, to gain a better perspective of tissue congener distribution and to evaluate the observed PCB levels against toxicologically significant levels for modes of action. Concentrations of 145 PCB congeners (a(145)PCBs) and 12 OCPs were measured with gas chromatography-ion trap mass spectrometry in 8 different tissues of 10 male northern fur seals. The mean concentrations of aOCPs [in ng/g lipid weight (lw)] were 1180 in blubber, 985 in the heart, 1007 in the liver, 817 in the kidney, 941 in muscle, 660 in reproductive tissues, 204 in the brain, and 322 in the lung. The mean concentrations of a(145)PCBs (in ng/g lw) were 823 in blubber, 777 in the liver, 732 in the heart, 646 in reproductive tissues, 638 in muscle, 587 in the kidney, 128 in the lung, and 74.3 in brain tissues. Concentrations of PCBs affecting the aryl hydrocarbon receptor expressed as total PCB toxic equivalents (aPCB-TEQs) ranged from 0.3 to 545 pg/g lw for the various tissues. The major contributors to aPCB-TEQs are CB-118 in muscle, brain, lung, kidney, and liver, CB-126 in blubber, and CB-118 and CB-126 equally in the heart and reproductive tissues. Concentrations of PCBs affecting Ca(2+) homeostatsis expressed as the neurotoxic equivalent (NEQ) showed aPCB-NEQs ranged from 17.7 to 215 ng/g lw in all tissues. Although no composite measure of perturbation of thyroid function is available, sufficient amounts of congeners with high binding to the thyroxine transport system were present to warrant consideration of this mode of action in future studies. Analyses of 145 PCBs and mode of action evaluation suggest Article in Journal/Newspaper Bering Sea Phoca vitulina Callorhinus ursinus Xiamen University Institutional Repository Bering Sea |
institution |
Open Polar |
collection |
Xiamen University Institutional Repository |
op_collection_id |
ftxiamenuniv |
language |
English |
topic |
PERSISTENT ORGANIC POLLUTANTS CALLORHINUS-URSINUS REFERENCE VALUES PHOCA-VITULINA HUMAN BLOOD CONTAMINATION MIXTURES MILK SEQUESTRATION NEUROTOXICITY |
spellingShingle |
PERSISTENT ORGANIC POLLUTANTS CALLORHINUS-URSINUS REFERENCE VALUES PHOCA-VITULINA HUMAN BLOOD CONTAMINATION MIXTURES MILK SEQUESTRATION NEUROTOXICITY Wang, D. L. Shelver, W. L. Atkinson, S. Mellish, J. A. Li, Q. X. 王德利 Tissue Distribution of Polychlorinated Biphenyls and Organochlorine Pesticides and Potential Toxicity to Alaskan Northern Fur Seals Assessed Using PCBs Congener Specific Mode of Action Schemes |
topic_facet |
PERSISTENT ORGANIC POLLUTANTS CALLORHINUS-URSINUS REFERENCE VALUES PHOCA-VITULINA HUMAN BLOOD CONTAMINATION MIXTURES MILK SEQUESTRATION NEUROTOXICITY |
description |
The fur seal (Callorhinus ursinus) population has decreased in their primary breeding grounds in the Bering Sea; contamination is among suspected causes. Our goal was to better understand the extent of contamination of seal tissues with certain organochlorine compounds by measuring the concentrations of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in fur seal tissues from St. Paul Island, to gain a better perspective of tissue congener distribution and to evaluate the observed PCB levels against toxicologically significant levels for modes of action. Concentrations of 145 PCB congeners (a(145)PCBs) and 12 OCPs were measured with gas chromatography-ion trap mass spectrometry in 8 different tissues of 10 male northern fur seals. The mean concentrations of aOCPs [in ng/g lipid weight (lw)] were 1180 in blubber, 985 in the heart, 1007 in the liver, 817 in the kidney, 941 in muscle, 660 in reproductive tissues, 204 in the brain, and 322 in the lung. The mean concentrations of a(145)PCBs (in ng/g lw) were 823 in blubber, 777 in the liver, 732 in the heart, 646 in reproductive tissues, 638 in muscle, 587 in the kidney, 128 in the lung, and 74.3 in brain tissues. Concentrations of PCBs affecting the aryl hydrocarbon receptor expressed as total PCB toxic equivalents (aPCB-TEQs) ranged from 0.3 to 545 pg/g lw for the various tissues. The major contributors to aPCB-TEQs are CB-118 in muscle, brain, lung, kidney, and liver, CB-126 in blubber, and CB-118 and CB-126 equally in the heart and reproductive tissues. Concentrations of PCBs affecting Ca(2+) homeostatsis expressed as the neurotoxic equivalent (NEQ) showed aPCB-NEQs ranged from 17.7 to 215 ng/g lw in all tissues. Although no composite measure of perturbation of thyroid function is available, sufficient amounts of congeners with high binding to the thyroxine transport system were present to warrant consideration of this mode of action in future studies. Analyses of 145 PCBs and mode of action evaluation suggest |
format |
Article in Journal/Newspaper |
author |
Wang, D. L. Shelver, W. L. Atkinson, S. Mellish, J. A. Li, Q. X. 王德利 |
author_facet |
Wang, D. L. Shelver, W. L. Atkinson, S. Mellish, J. A. Li, Q. X. 王德利 |
author_sort |
Wang, D. L. |
title |
Tissue Distribution of Polychlorinated Biphenyls and Organochlorine Pesticides and Potential Toxicity to Alaskan Northern Fur Seals Assessed Using PCBs Congener Specific Mode of Action Schemes |
title_short |
Tissue Distribution of Polychlorinated Biphenyls and Organochlorine Pesticides and Potential Toxicity to Alaskan Northern Fur Seals Assessed Using PCBs Congener Specific Mode of Action Schemes |
title_full |
Tissue Distribution of Polychlorinated Biphenyls and Organochlorine Pesticides and Potential Toxicity to Alaskan Northern Fur Seals Assessed Using PCBs Congener Specific Mode of Action Schemes |
title_fullStr |
Tissue Distribution of Polychlorinated Biphenyls and Organochlorine Pesticides and Potential Toxicity to Alaskan Northern Fur Seals Assessed Using PCBs Congener Specific Mode of Action Schemes |
title_full_unstemmed |
Tissue Distribution of Polychlorinated Biphenyls and Organochlorine Pesticides and Potential Toxicity to Alaskan Northern Fur Seals Assessed Using PCBs Congener Specific Mode of Action Schemes |
title_sort |
tissue distribution of polychlorinated biphenyls and organochlorine pesticides and potential toxicity to alaskan northern fur seals assessed using pcbs congener specific mode of action schemes |
publishDate |
2010 |
url |
http://dspace.xmu.edu.cn/handle/2288/60586 |
geographic |
Bering Sea |
geographic_facet |
Bering Sea |
genre |
Bering Sea Phoca vitulina Callorhinus ursinus |
genre_facet |
Bering Sea Phoca vitulina Callorhinus ursinus |
op_relation |
Archives of Environmental Contamination and Toxicology,58(2):478-488 0090-4341 ISI:000274314100023 http://dspace.xmu.edu.cn/handle/2288/60586 |
_version_ |
1766378238252154880 |