Multiple exportins influence thyroid hormone receptor localization
Southern Ocean primary productivity plays a key role in global ocean biogeochemistry and climate. At the Southern Ocean sea ice edge in coastal McMurdo Sound, we observed simultaneous cobalamin and iron limitation of surface water phytoplankton communities in late Austral summer. Cobalamin is produc...
Main Authors: | , , , , , , , , |
---|---|
Format: | Text |
Language: | unknown |
Published: |
W&M ScholarWorks
2015
|
Subjects: | |
Online Access: | https://scholarworks.wm.edu/aspubs/935 https://scholarworks.wm.edu/cgi/viewcontent.cgi?article=1945&context=aspubs |
id |
ftwilliammarycol:oai:scholarworks.wm.edu:aspubs-1945 |
---|---|
record_format |
openpolar |
spelling |
ftwilliammarycol:oai:scholarworks.wm.edu:aspubs-1945 2023-05-15T17:10:36+02:00 Multiple exportins influence thyroid hormone receptor localization Subramanian, Kelly Sue Dziedzic, Rose C. Nelson, Hallie N Bertrand, Erin M. McCrow, John P. Moustafa, Ahmed Sipler, Rachel E. Spackeen, Jenna L. Bronk, Deborah A. 2015-01-01T08:00:00Z application/pdf https://scholarworks.wm.edu/aspubs/935 https://scholarworks.wm.edu/cgi/viewcontent.cgi?article=1945&context=aspubs unknown W&M ScholarWorks https://scholarworks.wm.edu/aspubs/935 https://scholarworks.wm.edu/cgi/viewcontent.cgi?article=1945&context=aspubs Arts & Sciences Articles text 2015 ftwilliammarycol 2021-01-03T17:24:56Z Southern Ocean primary productivity plays a key role in global ocean biogeochemistry and climate. At the Southern Ocean sea ice edge in coastal McMurdo Sound, we observed simultaneous cobalamin and iron limitation of surface water phytoplankton communities in late Austral summer. Cobalamin is produced only by bacteria and archaea, suggesting phytoplankton-bacterial interactions must play a role in this limitation. To characterize these interactions and investigate the molecular basis of multiple nutrient limitation, we examined transitions in global gene expression over short time scales, induced by shifts in micronutrient availability. Diatoms, the dominant primary producers, exhibited transcriptional patterns indicative of co-occurring iron and cobalamin deprivation. The major contributor to cobalamin biosynthesis gene expression was a gammaproteobacterial population, Oceanospirillaceae ASP10-02a. This group also contributed significantly to metagenomic cobalamin biosynthesis gene abundance throughout Southern Ocean surface waters. Oceanospirillaceae ASP10-02a displayed elevated expression of organic matter acquisition and cell surface attachment-related genes, consistent with a mutualistic relationship in which they are dependent on phytoplankton growth to fuel cobalamin production. Separate bacterial groups, including Methylophaga, appeared to rely on phytoplankton for carbon and energy sources, but displayed gene expression patterns consistent with iron and cobalamin deprivation. This suggests they also compete with phytoplankton and are important cobalamin consumers. Expression patterns of siderophore-related genes offer evidence for bacterial influences on iron availability as well. The nature and degree of this episodic colimitation appear to be mediated by a series of phytoplankton-bacterial interactions in both positive and negative feedback loops. Text McMurdo Sound Sea ice Southern Ocean W&M ScholarWorks Southern Ocean Austral McMurdo Sound |
institution |
Open Polar |
collection |
W&M ScholarWorks |
op_collection_id |
ftwilliammarycol |
language |
unknown |
description |
Southern Ocean primary productivity plays a key role in global ocean biogeochemistry and climate. At the Southern Ocean sea ice edge in coastal McMurdo Sound, we observed simultaneous cobalamin and iron limitation of surface water phytoplankton communities in late Austral summer. Cobalamin is produced only by bacteria and archaea, suggesting phytoplankton-bacterial interactions must play a role in this limitation. To characterize these interactions and investigate the molecular basis of multiple nutrient limitation, we examined transitions in global gene expression over short time scales, induced by shifts in micronutrient availability. Diatoms, the dominant primary producers, exhibited transcriptional patterns indicative of co-occurring iron and cobalamin deprivation. The major contributor to cobalamin biosynthesis gene expression was a gammaproteobacterial population, Oceanospirillaceae ASP10-02a. This group also contributed significantly to metagenomic cobalamin biosynthesis gene abundance throughout Southern Ocean surface waters. Oceanospirillaceae ASP10-02a displayed elevated expression of organic matter acquisition and cell surface attachment-related genes, consistent with a mutualistic relationship in which they are dependent on phytoplankton growth to fuel cobalamin production. Separate bacterial groups, including Methylophaga, appeared to rely on phytoplankton for carbon and energy sources, but displayed gene expression patterns consistent with iron and cobalamin deprivation. This suggests they also compete with phytoplankton and are important cobalamin consumers. Expression patterns of siderophore-related genes offer evidence for bacterial influences on iron availability as well. The nature and degree of this episodic colimitation appear to be mediated by a series of phytoplankton-bacterial interactions in both positive and negative feedback loops. |
format |
Text |
author |
Subramanian, Kelly Sue Dziedzic, Rose C. Nelson, Hallie N Bertrand, Erin M. McCrow, John P. Moustafa, Ahmed Sipler, Rachel E. Spackeen, Jenna L. Bronk, Deborah A. |
spellingShingle |
Subramanian, Kelly Sue Dziedzic, Rose C. Nelson, Hallie N Bertrand, Erin M. McCrow, John P. Moustafa, Ahmed Sipler, Rachel E. Spackeen, Jenna L. Bronk, Deborah A. Multiple exportins influence thyroid hormone receptor localization |
author_facet |
Subramanian, Kelly Sue Dziedzic, Rose C. Nelson, Hallie N Bertrand, Erin M. McCrow, John P. Moustafa, Ahmed Sipler, Rachel E. Spackeen, Jenna L. Bronk, Deborah A. |
author_sort |
Subramanian, Kelly Sue |
title |
Multiple exportins influence thyroid hormone receptor localization |
title_short |
Multiple exportins influence thyroid hormone receptor localization |
title_full |
Multiple exportins influence thyroid hormone receptor localization |
title_fullStr |
Multiple exportins influence thyroid hormone receptor localization |
title_full_unstemmed |
Multiple exportins influence thyroid hormone receptor localization |
title_sort |
multiple exportins influence thyroid hormone receptor localization |
publisher |
W&M ScholarWorks |
publishDate |
2015 |
url |
https://scholarworks.wm.edu/aspubs/935 https://scholarworks.wm.edu/cgi/viewcontent.cgi?article=1945&context=aspubs |
geographic |
Southern Ocean Austral McMurdo Sound |
geographic_facet |
Southern Ocean Austral McMurdo Sound |
genre |
McMurdo Sound Sea ice Southern Ocean |
genre_facet |
McMurdo Sound Sea ice Southern Ocean |
op_source |
Arts & Sciences Articles |
op_relation |
https://scholarworks.wm.edu/aspubs/935 https://scholarworks.wm.edu/cgi/viewcontent.cgi?article=1945&context=aspubs |
_version_ |
1766067237444124672 |