Iron mobilization during lactation reduces oxygen stores in a diving mammal

© The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Shero, M. R., Kirkham, A. L., Costa, D. P., & Burns, J. M. Iron mobilization during lactation reduces oxygen stores in a diving mammal. Nature C...

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Published in:Nature Communications
Main Authors: Shero, Michelle R., Kirkham, Amy L., Costa, Daniel P., Burns, Jennifer M.
Format: Article in Journal/Newspaper
Language:unknown
Published: Nature Research 2022
Subjects:
Online Access:https://hdl.handle.net/1912/29509
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spelling ftwhoas:oai:darchive.mblwhoilibrary.org:1912/29509 2023-05-15T18:43:24+02:00 Iron mobilization during lactation reduces oxygen stores in a diving mammal Shero, Michelle R. Kirkham, Amy L. Costa, Daniel P. Burns, Jennifer M. 2022-08-02 https://hdl.handle.net/1912/29509 unknown Nature Research https://doi.org/10.1038/s41467-022-31863-7 Shero, M. R., Kirkham, A. L., Costa, D. P., & Burns, J. M. (2022). Iron mobilization during lactation reduces oxygen stores in a diving mammal. Nature Communications, 13(1), 4322. https://hdl.handle.net/1912/29509 doi:10.1038/s41467-022-31863-7 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ CC-BY Shero, M. R., Kirkham, A. L., Costa, D. P., & Burns, J. M. (2022). Iron mobilization during lactation reduces oxygen stores in a diving mammal. Nature Communications, 13(1), 4322. doi:10.1038/s41467-022-31863-7 Animal physiology Ecophysiology Homeostasis Article 2022 ftwhoas https://doi.org/10.1038/s41467-022-31863-7 2022-11-19T23:57:10Z © The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Shero, M. R., Kirkham, A. L., Costa, D. P., & Burns, J. M. Iron mobilization during lactation reduces oxygen stores in a diving mammal. Nature Communications, 13(1), (2022): 4322, https://doi.org/10.1038/s41467-022-31863-7. The profound impacts that maternal provisioning of finite energy resources has on offspring survival have been extensively studied across mammals. This study shows that in addition to calories, high hemoprotein concentrations in diving mammals necessitates exceptional female-to-pup iron transfer. Numerous indices of iron mobilization (ferritin, serum iron, total-iron-binding-capacity, transferrin saturation) were significantly elevated during lactation in adult female Weddell seals (Leptonychotes weddellii), but not in skip-breeders. Iron was mobilized from endogenous stores for incorporation into the Weddell seal’s milk at concentrations up to 100× higher than terrestrial mammals. Such high rates of iron offload to offspring drew from the female’s own heme stores and led to compromised physiologic dive capacities (hemoglobin, myoglobin, and total body oxygen stores) after weaning their pups, which was further reflected in shorter dive durations. We demonstrate that lactational iron transfer shapes physiologic dive thresholds, identifying a cost of reproduction to a marine mammal. This research was conducted with support from NSF ANT-0838892 to DPC; ANT-0838937 and ANT-1246463 to JMB (which also supported ALK and MRS); and The Investment in Science Fund at WHOI to MRS. Article in Journal/Newspaper Weddell Seals Woods Hole Scientific Community: WHOAS (Woods Hole Open Access Server) Weddell Nature Communications 13 1
institution Open Polar
collection Woods Hole Scientific Community: WHOAS (Woods Hole Open Access Server)
op_collection_id ftwhoas
language unknown
topic Animal physiology
Ecophysiology
Homeostasis
spellingShingle Animal physiology
Ecophysiology
Homeostasis
Shero, Michelle R.
Kirkham, Amy L.
Costa, Daniel P.
Burns, Jennifer M.
Iron mobilization during lactation reduces oxygen stores in a diving mammal
topic_facet Animal physiology
Ecophysiology
Homeostasis
description © The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Shero, M. R., Kirkham, A. L., Costa, D. P., & Burns, J. M. Iron mobilization during lactation reduces oxygen stores in a diving mammal. Nature Communications, 13(1), (2022): 4322, https://doi.org/10.1038/s41467-022-31863-7. The profound impacts that maternal provisioning of finite energy resources has on offspring survival have been extensively studied across mammals. This study shows that in addition to calories, high hemoprotein concentrations in diving mammals necessitates exceptional female-to-pup iron transfer. Numerous indices of iron mobilization (ferritin, serum iron, total-iron-binding-capacity, transferrin saturation) were significantly elevated during lactation in adult female Weddell seals (Leptonychotes weddellii), but not in skip-breeders. Iron was mobilized from endogenous stores for incorporation into the Weddell seal’s milk at concentrations up to 100× higher than terrestrial mammals. Such high rates of iron offload to offspring drew from the female’s own heme stores and led to compromised physiologic dive capacities (hemoglobin, myoglobin, and total body oxygen stores) after weaning their pups, which was further reflected in shorter dive durations. We demonstrate that lactational iron transfer shapes physiologic dive thresholds, identifying a cost of reproduction to a marine mammal. This research was conducted with support from NSF ANT-0838892 to DPC; ANT-0838937 and ANT-1246463 to JMB (which also supported ALK and MRS); and The Investment in Science Fund at WHOI to MRS.
format Article in Journal/Newspaper
author Shero, Michelle R.
Kirkham, Amy L.
Costa, Daniel P.
Burns, Jennifer M.
author_facet Shero, Michelle R.
Kirkham, Amy L.
Costa, Daniel P.
Burns, Jennifer M.
author_sort Shero, Michelle R.
title Iron mobilization during lactation reduces oxygen stores in a diving mammal
title_short Iron mobilization during lactation reduces oxygen stores in a diving mammal
title_full Iron mobilization during lactation reduces oxygen stores in a diving mammal
title_fullStr Iron mobilization during lactation reduces oxygen stores in a diving mammal
title_full_unstemmed Iron mobilization during lactation reduces oxygen stores in a diving mammal
title_sort iron mobilization during lactation reduces oxygen stores in a diving mammal
publisher Nature Research
publishDate 2022
url https://hdl.handle.net/1912/29509
geographic Weddell
geographic_facet Weddell
genre Weddell Seals
genre_facet Weddell Seals
op_source Shero, M. R., Kirkham, A. L., Costa, D. P., & Burns, J. M. (2022). Iron mobilization during lactation reduces oxygen stores in a diving mammal. Nature Communications, 13(1), 4322.
doi:10.1038/s41467-022-31863-7
op_relation https://doi.org/10.1038/s41467-022-31863-7
Shero, M. R., Kirkham, A. L., Costa, D. P., & Burns, J. M. (2022). Iron mobilization during lactation reduces oxygen stores in a diving mammal. Nature Communications, 13(1), 4322.
https://hdl.handle.net/1912/29509
doi:10.1038/s41467-022-31863-7
op_rights Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
op_rightsnorm CC-BY
op_doi https://doi.org/10.1038/s41467-022-31863-7
container_title Nature Communications
container_volume 13
container_issue 1
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