The ontogenic transcription of complement component C3 and Apolipoprotein A-I tRNA in Atlantic cod (Gadus morhua L.): a role in development and homeostasis?
The complement system is important both in the innate and adaptive immune response, with C3 as the central protein of all three activation pathways. Apolipoprotein A-I (ApoLP A-I), a high-density lipoprotein (HDL), has been shown to have a regulatory role in the complement system by inhibiting the f...
Published in: | Developmental & Comparative Immunology |
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ftwestminres:oai:westminsterresearch.westminster.ac.uk:9v8y0 2023-05-15T15:27:35+02:00 The ontogenic transcription of complement component C3 and Apolipoprotein A-I tRNA in Atlantic cod (Gadus morhua L.): a role in development and homeostasis? Lange, S. Dodds, A.W. Bambir, S.H. Gudmundsdottir, S. Magnadóttir, B. 2005 https://westminsterresearch.westminster.ac.uk/item/9v8y0/the-ontogenic-transcription-of-complement-component-c3-and-apolipoprotein-a-i-trna-in-atlantic-cod-gadus-morhua-l-a-role-in-development-and-homeostasis https://doi.org/10.1016/j.dci.2005.03.009 unknown Elsevier https://doi.org/10.1016/j.dci.2005.03.009 Lange, S., Dodds, A.W., Bambir, S.H., Gudmundsdottir, S. and Magnadóttir, B. 2005. The ontogenic transcription of complement component C3 and Apolipoprotein A-I tRNA in Atlantic cod (Gadus morhua L.): a role in development and homeostasis? Developmental & Comparative Immunology. 29 (12), p. 1065–1077. https://doi.org/10.1016/j.dci.2005.03.009 Complement C3 Apolipoprotein A-I Cod (Gadus morhua L.) Ontogeny Embryo Development Apoptosis journal-article PeerReviewed 2005 ftwestminres https://doi.org/10.1016/j.dci.2005.03.009 2023-03-26T20:46:14Z The complement system is important both in the innate and adaptive immune response, with C3 as the central protein of all three activation pathways. Apolipoprotein A-I (ApoLP A-I), a high-density lipoprotein (HDL), has been shown to have a regulatory role in the complement system by inhibiting the formation of the membrane attack complex (MAC). Complement has been associated with apoptotic functions, which are important in the immune response and are involved in organ formation and homeostasis. mRNA probes for cod C3 and ApoLP A-I were synthesized and in situ hybridisation used to monitor the ontogenic development of cod from fertilised eggs until 57 days after hatching. Both C3 and ApoLP A-I transcription was detected in the central nervous system (CNS), eye, kidney, liver, muscle, intestines, skin and chondrocytes at different stages of development. Using TUNEL staining, apoptotic cells were identified within the same areas from 4 to 57 days posthatching. The present findings may suggest a role for C3 and ApoLP A-I during larval development and a possible role in the homeostasis of various organs in cod. Text atlantic cod Gadus morhua University of Westminster: WestminsterResearch Developmental & Comparative Immunology 29 12 1065 1077 |
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University of Westminster: WestminsterResearch |
op_collection_id |
ftwestminres |
language |
unknown |
topic |
Complement C3 Apolipoprotein A-I Cod (Gadus morhua L.) Ontogeny Embryo Development Apoptosis |
spellingShingle |
Complement C3 Apolipoprotein A-I Cod (Gadus morhua L.) Ontogeny Embryo Development Apoptosis Lange, S. Dodds, A.W. Bambir, S.H. Gudmundsdottir, S. Magnadóttir, B. The ontogenic transcription of complement component C3 and Apolipoprotein A-I tRNA in Atlantic cod (Gadus morhua L.): a role in development and homeostasis? |
topic_facet |
Complement C3 Apolipoprotein A-I Cod (Gadus morhua L.) Ontogeny Embryo Development Apoptosis |
description |
The complement system is important both in the innate and adaptive immune response, with C3 as the central protein of all three activation pathways. Apolipoprotein A-I (ApoLP A-I), a high-density lipoprotein (HDL), has been shown to have a regulatory role in the complement system by inhibiting the formation of the membrane attack complex (MAC). Complement has been associated with apoptotic functions, which are important in the immune response and are involved in organ formation and homeostasis. mRNA probes for cod C3 and ApoLP A-I were synthesized and in situ hybridisation used to monitor the ontogenic development of cod from fertilised eggs until 57 days after hatching. Both C3 and ApoLP A-I transcription was detected in the central nervous system (CNS), eye, kidney, liver, muscle, intestines, skin and chondrocytes at different stages of development. Using TUNEL staining, apoptotic cells were identified within the same areas from 4 to 57 days posthatching. The present findings may suggest a role for C3 and ApoLP A-I during larval development and a possible role in the homeostasis of various organs in cod. |
format |
Text |
author |
Lange, S. Dodds, A.W. Bambir, S.H. Gudmundsdottir, S. Magnadóttir, B. |
author_facet |
Lange, S. Dodds, A.W. Bambir, S.H. Gudmundsdottir, S. Magnadóttir, B. |
author_sort |
Lange, S. |
title |
The ontogenic transcription of complement component C3 and Apolipoprotein A-I tRNA in Atlantic cod (Gadus morhua L.): a role in development and homeostasis? |
title_short |
The ontogenic transcription of complement component C3 and Apolipoprotein A-I tRNA in Atlantic cod (Gadus morhua L.): a role in development and homeostasis? |
title_full |
The ontogenic transcription of complement component C3 and Apolipoprotein A-I tRNA in Atlantic cod (Gadus morhua L.): a role in development and homeostasis? |
title_fullStr |
The ontogenic transcription of complement component C3 and Apolipoprotein A-I tRNA in Atlantic cod (Gadus morhua L.): a role in development and homeostasis? |
title_full_unstemmed |
The ontogenic transcription of complement component C3 and Apolipoprotein A-I tRNA in Atlantic cod (Gadus morhua L.): a role in development and homeostasis? |
title_sort |
ontogenic transcription of complement component c3 and apolipoprotein a-i trna in atlantic cod (gadus morhua l.): a role in development and homeostasis? |
publisher |
Elsevier |
publishDate |
2005 |
url |
https://westminsterresearch.westminster.ac.uk/item/9v8y0/the-ontogenic-transcription-of-complement-component-c3-and-apolipoprotein-a-i-trna-in-atlantic-cod-gadus-morhua-l-a-role-in-development-and-homeostasis https://doi.org/10.1016/j.dci.2005.03.009 |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_relation |
https://doi.org/10.1016/j.dci.2005.03.009 Lange, S., Dodds, A.W., Bambir, S.H., Gudmundsdottir, S. and Magnadóttir, B. 2005. The ontogenic transcription of complement component C3 and Apolipoprotein A-I tRNA in Atlantic cod (Gadus morhua L.): a role in development and homeostasis? Developmental & Comparative Immunology. 29 (12), p. 1065–1077. https://doi.org/10.1016/j.dci.2005.03.009 |
op_doi |
https://doi.org/10.1016/j.dci.2005.03.009 |
container_title |
Developmental & Comparative Immunology |
container_volume |
29 |
container_issue |
12 |
container_start_page |
1065 |
op_container_end_page |
1077 |
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1766358006360965120 |