Sanguiin H-6 fractionated from cloudberry (Rubus chamaemorus) seeds can prevent the methicillin-resistant staphylococcus aureus biofilm development during wound infection
Staphylococcus aureus is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant S. aureus (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins suc...
Published in: | Antibiotics |
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Main Authors: | , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
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2021
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Online Access: | https://cris.vtt.fi/en/publications/be68e325-e776-489a-a3d1-9cfa9d81fe9c https://doi.org/10.3390/antibiotics10121481 https://cris.vtt.fi/ws/files/54823680/antibiotics10121481.pdf http://www.scopus.com/inward/record.url?scp=85121577670&partnerID=8YFLogxK |
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ftvttcrispub:oai:cris.vtt.fi:publications/be68e325-e776-489a-a3d1-9cfa9d81fe9c 2024-06-23T07:56:28+00:00 Sanguiin H-6 fractionated from cloudberry (Rubus chamaemorus) seeds can prevent the methicillin-resistant staphylococcus aureus biofilm development during wound infection Aguilera-Correa, John Jairo Fernández-López, Sara Cuñas-Figueroa, Iskra Dennisse Pérez-Rial, Sandra Alakomi, Hanna Leena Nohynek, Liisa Oksman-Caldentey, Kirsi Marja Salminen, Juha Pekka Esteban, Jaime Cuadros, Juan Puupponen-Pimiä, Riitta Perez-Tanoira, Ramon Kinnari, Teemu J. 2021-12-03 application/pdf https://cris.vtt.fi/en/publications/be68e325-e776-489a-a3d1-9cfa9d81fe9c https://doi.org/10.3390/antibiotics10121481 https://cris.vtt.fi/ws/files/54823680/antibiotics10121481.pdf http://www.scopus.com/inward/record.url?scp=85121577670&partnerID=8YFLogxK eng eng https://cris.vtt.fi/en/publications/be68e325-e776-489a-a3d1-9cfa9d81fe9c info:eu-repo/semantics/openAccess Aguilera-Correa , J J , Fernández-López , S , Cuñas-Figueroa , I D , Pérez-Rial , S , Alakomi , H L , Nohynek , L , Oksman-Caldentey , K M , Salminen , J P , Esteban , J , Cuadros , J , Puupponen-Pimiä , R , Perez-Tanoira , R & Kinnari , T J 2021 , ' Sanguiin H-6 fractionated from cloudberry (Rubus chamaemorus) seeds can prevent the methicillin-resistant staphylococcus aureus biofilm development during wound infection ' , Antibiotics , vol. 10 , no. 12 , 1481 . https://doi.org/10.3390/antibiotics10121481 Biofilm Cloudberry Ellagitannin Methicillin-resistant S. aureus Rubus /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being article 2021 ftvttcrispub https://doi.org/10.3390/antibiotics10121481 2024-06-05T23:41:21Z Staphylococcus aureus is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant S. aureus (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins such as sanguiin H-6 and lambertianin C, the main phenolic compounds in Rubus seeds, have shown antimicrobial activity. The aim of this study was to evaluate the effect of sanguiin H-6 and lambertianin C fractionated from cloudberry seeds, on the MRSA growth, and as treatment of a MRSA biofilm development in different growth media in vitro and in vivo by using a murine wound infection model where sanguiin H-6 and lambertianin C were used to prevent the MRSA infection. Sanguiin H-6 and lambertianin C inhibited the in vitro biofilm development and growth of MRSA. Furthermore, sanguiin H-6 showed significant anti-MRSA effect in the in vivo wound model. Our study shows the possible use of sanguiin H-6 as a preventive measure in surgical sites to avoid postoperative infections, whilst lambertianin C showed no anti-MRSA activity. Article in Journal/Newspaper Rubus chamaemorus VTT's Research Information Portal Antibiotics 10 12 1481 |
institution |
Open Polar |
collection |
VTT's Research Information Portal |
op_collection_id |
ftvttcrispub |
language |
English |
topic |
Biofilm Cloudberry Ellagitannin Methicillin-resistant S. aureus Rubus /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
spellingShingle |
Biofilm Cloudberry Ellagitannin Methicillin-resistant S. aureus Rubus /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being Aguilera-Correa, John Jairo Fernández-López, Sara Cuñas-Figueroa, Iskra Dennisse Pérez-Rial, Sandra Alakomi, Hanna Leena Nohynek, Liisa Oksman-Caldentey, Kirsi Marja Salminen, Juha Pekka Esteban, Jaime Cuadros, Juan Puupponen-Pimiä, Riitta Perez-Tanoira, Ramon Kinnari, Teemu J. Sanguiin H-6 fractionated from cloudberry (Rubus chamaemorus) seeds can prevent the methicillin-resistant staphylococcus aureus biofilm development during wound infection |
topic_facet |
Biofilm Cloudberry Ellagitannin Methicillin-resistant S. aureus Rubus /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
description |
Staphylococcus aureus is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant S. aureus (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins such as sanguiin H-6 and lambertianin C, the main phenolic compounds in Rubus seeds, have shown antimicrobial activity. The aim of this study was to evaluate the effect of sanguiin H-6 and lambertianin C fractionated from cloudberry seeds, on the MRSA growth, and as treatment of a MRSA biofilm development in different growth media in vitro and in vivo by using a murine wound infection model where sanguiin H-6 and lambertianin C were used to prevent the MRSA infection. Sanguiin H-6 and lambertianin C inhibited the in vitro biofilm development and growth of MRSA. Furthermore, sanguiin H-6 showed significant anti-MRSA effect in the in vivo wound model. Our study shows the possible use of sanguiin H-6 as a preventive measure in surgical sites to avoid postoperative infections, whilst lambertianin C showed no anti-MRSA activity. |
format |
Article in Journal/Newspaper |
author |
Aguilera-Correa, John Jairo Fernández-López, Sara Cuñas-Figueroa, Iskra Dennisse Pérez-Rial, Sandra Alakomi, Hanna Leena Nohynek, Liisa Oksman-Caldentey, Kirsi Marja Salminen, Juha Pekka Esteban, Jaime Cuadros, Juan Puupponen-Pimiä, Riitta Perez-Tanoira, Ramon Kinnari, Teemu J. |
author_facet |
Aguilera-Correa, John Jairo Fernández-López, Sara Cuñas-Figueroa, Iskra Dennisse Pérez-Rial, Sandra Alakomi, Hanna Leena Nohynek, Liisa Oksman-Caldentey, Kirsi Marja Salminen, Juha Pekka Esteban, Jaime Cuadros, Juan Puupponen-Pimiä, Riitta Perez-Tanoira, Ramon Kinnari, Teemu J. |
author_sort |
Aguilera-Correa, John Jairo |
title |
Sanguiin H-6 fractionated from cloudberry (Rubus chamaemorus) seeds can prevent the methicillin-resistant staphylococcus aureus biofilm development during wound infection |
title_short |
Sanguiin H-6 fractionated from cloudberry (Rubus chamaemorus) seeds can prevent the methicillin-resistant staphylococcus aureus biofilm development during wound infection |
title_full |
Sanguiin H-6 fractionated from cloudberry (Rubus chamaemorus) seeds can prevent the methicillin-resistant staphylococcus aureus biofilm development during wound infection |
title_fullStr |
Sanguiin H-6 fractionated from cloudberry (Rubus chamaemorus) seeds can prevent the methicillin-resistant staphylococcus aureus biofilm development during wound infection |
title_full_unstemmed |
Sanguiin H-6 fractionated from cloudberry (Rubus chamaemorus) seeds can prevent the methicillin-resistant staphylococcus aureus biofilm development during wound infection |
title_sort |
sanguiin h-6 fractionated from cloudberry (rubus chamaemorus) seeds can prevent the methicillin-resistant staphylococcus aureus biofilm development during wound infection |
publishDate |
2021 |
url |
https://cris.vtt.fi/en/publications/be68e325-e776-489a-a3d1-9cfa9d81fe9c https://doi.org/10.3390/antibiotics10121481 https://cris.vtt.fi/ws/files/54823680/antibiotics10121481.pdf http://www.scopus.com/inward/record.url?scp=85121577670&partnerID=8YFLogxK |
genre |
Rubus chamaemorus |
genre_facet |
Rubus chamaemorus |
op_source |
Aguilera-Correa , J J , Fernández-López , S , Cuñas-Figueroa , I D , Pérez-Rial , S , Alakomi , H L , Nohynek , L , Oksman-Caldentey , K M , Salminen , J P , Esteban , J , Cuadros , J , Puupponen-Pimiä , R , Perez-Tanoira , R & Kinnari , T J 2021 , ' Sanguiin H-6 fractionated from cloudberry (Rubus chamaemorus) seeds can prevent the methicillin-resistant staphylococcus aureus biofilm development during wound infection ' , Antibiotics , vol. 10 , no. 12 , 1481 . https://doi.org/10.3390/antibiotics10121481 |
op_relation |
https://cris.vtt.fi/en/publications/be68e325-e776-489a-a3d1-9cfa9d81fe9c |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3390/antibiotics10121481 |
container_title |
Antibiotics |
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10 |
container_issue |
12 |
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1481 |
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1802649555138772992 |