Reduction of methicillin-resistant Staphylococcus aureus biofilm growth and development using arctic berry extracts
Introduction: Surgical site infection remains a devastating and feared complication of surgery caused mainly by Staphylococcus aureus (S. aureus). More specifically, methicillin-resistant S. aureus (MRSA) infection poses a serious threat to global health. Therefore, developing new antibacterial agen...
Published in: | Frontiers in Cellular and Infection Microbiology |
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2023
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Online Access: | https://cris.vtt.fi/en/publications/7ebbbfdc-5ca0-4c71-9f9f-5e99998b836c https://doi.org/10.3389/fcimb.2023.1176755 http://www.scopus.com/inward/record.url?scp=85164109460&partnerID=8YFLogxK |
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ftvttcrispub:oai:cris.vtt.fi:publications/7ebbbfdc-5ca0-4c71-9f9f-5e99998b836c 2024-06-23T07:48:37+00:00 Reduction of methicillin-resistant Staphylococcus aureus biofilm growth and development using arctic berry extracts Aguilera-Correa, John Jairo Nohynek, Liisa Alakomi, Hanna Leena Esteban, Jaime Oksman-Caldentey, Kirsi Marja Puupponen-Pimiä, Riitta Kinnari, Teemu J. Perez-Tanoira, Ramon 2023-06-23 https://cris.vtt.fi/en/publications/7ebbbfdc-5ca0-4c71-9f9f-5e99998b836c https://doi.org/10.3389/fcimb.2023.1176755 http://www.scopus.com/inward/record.url?scp=85164109460&partnerID=8YFLogxK eng eng https://cris.vtt.fi/en/publications/7ebbbfdc-5ca0-4c71-9f9f-5e99998b836c info:eu-repo/semantics/openAccess Aguilera-Correa , J J , Nohynek , L , Alakomi , H L , Esteban , J , Oksman-Caldentey , K M , Puupponen-Pimiä , R , Kinnari , T J & Perez-Tanoira , R 2023 , ' Reduction of methicillin-resistant Staphylococcus aureus biofilm growth and development using arctic berry extracts ' , Frontiers in cellular and infection microbiology , vol. 13 , 1176755 . https://doi.org/10.3389/fcimb.2023.1176755 antimicrobial berry extract biofilm methicillin-resistant Staphylococcus aureus (MRSA) surgical infection /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being article 2023 ftvttcrispub https://doi.org/10.3389/fcimb.2023.1176755 2024-06-05T23:41:21Z Introduction: Surgical site infection remains a devastating and feared complication of surgery caused mainly by Staphylococcus aureus (S. aureus). More specifically, methicillin-resistant S. aureus (MRSA) infection poses a serious threat to global health. Therefore, developing new antibacterial agents to address drug resistance are urgently needed. Compounds derived from natural berries have shown a strong antimicrobial potential. Methods: This study aimed to evaluate the effect of various extracts from two arctic berries, cloudberry (Rubus chamaemorus) and raspberry (Rubus idaeus), on the development of an MRSA biofilm and as treatment on a mature MRSA biofilm. Furthermore, we evaluated the ability of two cloudberry seed-coat fractions, hydrothermal extract and ethanol extract, and the wet-milled hydrothermal extract of a raspberry press cake to inhibit and treat biofilm development in a wound-like medium. To do so, we used a model strain and two clinical strains isolated from infected patients. Results: All berry extracts prevented biofilm development of the three MRSA strains, except the raspberry press cake hydrothermal extract, which produced a diminished anti-staphylococcal effect. Discussion: The studied arctic berry extracts can be used as a treatment for a mature MRSA biofilm, however some limitations in their use exist. Article in Journal/Newspaper Arctic Arctic Rubus chamaemorus VTT's Research Information Portal Arctic Frontiers in Cellular and Infection Microbiology 13 |
institution |
Open Polar |
collection |
VTT's Research Information Portal |
op_collection_id |
ftvttcrispub |
language |
English |
topic |
antimicrobial berry extract biofilm methicillin-resistant Staphylococcus aureus (MRSA) surgical infection /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
spellingShingle |
antimicrobial berry extract biofilm methicillin-resistant Staphylococcus aureus (MRSA) surgical infection /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being Aguilera-Correa, John Jairo Nohynek, Liisa Alakomi, Hanna Leena Esteban, Jaime Oksman-Caldentey, Kirsi Marja Puupponen-Pimiä, Riitta Kinnari, Teemu J. Perez-Tanoira, Ramon Reduction of methicillin-resistant Staphylococcus aureus biofilm growth and development using arctic berry extracts |
topic_facet |
antimicrobial berry extract biofilm methicillin-resistant Staphylococcus aureus (MRSA) surgical infection /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
description |
Introduction: Surgical site infection remains a devastating and feared complication of surgery caused mainly by Staphylococcus aureus (S. aureus). More specifically, methicillin-resistant S. aureus (MRSA) infection poses a serious threat to global health. Therefore, developing new antibacterial agents to address drug resistance are urgently needed. Compounds derived from natural berries have shown a strong antimicrobial potential. Methods: This study aimed to evaluate the effect of various extracts from two arctic berries, cloudberry (Rubus chamaemorus) and raspberry (Rubus idaeus), on the development of an MRSA biofilm and as treatment on a mature MRSA biofilm. Furthermore, we evaluated the ability of two cloudberry seed-coat fractions, hydrothermal extract and ethanol extract, and the wet-milled hydrothermal extract of a raspberry press cake to inhibit and treat biofilm development in a wound-like medium. To do so, we used a model strain and two clinical strains isolated from infected patients. Results: All berry extracts prevented biofilm development of the three MRSA strains, except the raspberry press cake hydrothermal extract, which produced a diminished anti-staphylococcal effect. Discussion: The studied arctic berry extracts can be used as a treatment for a mature MRSA biofilm, however some limitations in their use exist. |
format |
Article in Journal/Newspaper |
author |
Aguilera-Correa, John Jairo Nohynek, Liisa Alakomi, Hanna Leena Esteban, Jaime Oksman-Caldentey, Kirsi Marja Puupponen-Pimiä, Riitta Kinnari, Teemu J. Perez-Tanoira, Ramon |
author_facet |
Aguilera-Correa, John Jairo Nohynek, Liisa Alakomi, Hanna Leena Esteban, Jaime Oksman-Caldentey, Kirsi Marja Puupponen-Pimiä, Riitta Kinnari, Teemu J. Perez-Tanoira, Ramon |
author_sort |
Aguilera-Correa, John Jairo |
title |
Reduction of methicillin-resistant Staphylococcus aureus biofilm growth and development using arctic berry extracts |
title_short |
Reduction of methicillin-resistant Staphylococcus aureus biofilm growth and development using arctic berry extracts |
title_full |
Reduction of methicillin-resistant Staphylococcus aureus biofilm growth and development using arctic berry extracts |
title_fullStr |
Reduction of methicillin-resistant Staphylococcus aureus biofilm growth and development using arctic berry extracts |
title_full_unstemmed |
Reduction of methicillin-resistant Staphylococcus aureus biofilm growth and development using arctic berry extracts |
title_sort |
reduction of methicillin-resistant staphylococcus aureus biofilm growth and development using arctic berry extracts |
publishDate |
2023 |
url |
https://cris.vtt.fi/en/publications/7ebbbfdc-5ca0-4c71-9f9f-5e99998b836c https://doi.org/10.3389/fcimb.2023.1176755 http://www.scopus.com/inward/record.url?scp=85164109460&partnerID=8YFLogxK |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Arctic Rubus chamaemorus |
genre_facet |
Arctic Arctic Rubus chamaemorus |
op_source |
Aguilera-Correa , J J , Nohynek , L , Alakomi , H L , Esteban , J , Oksman-Caldentey , K M , Puupponen-Pimiä , R , Kinnari , T J & Perez-Tanoira , R 2023 , ' Reduction of methicillin-resistant Staphylococcus aureus biofilm growth and development using arctic berry extracts ' , Frontiers in cellular and infection microbiology , vol. 13 , 1176755 . https://doi.org/10.3389/fcimb.2023.1176755 |
op_relation |
https://cris.vtt.fi/en/publications/7ebbbfdc-5ca0-4c71-9f9f-5e99998b836c |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3389/fcimb.2023.1176755 |
container_title |
Frontiers in Cellular and Infection Microbiology |
container_volume |
13 |
_version_ |
1802638968855986176 |