Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea
The gonads of sea urchins have been consumed by humans since ancient times. However, relatively little information is available on their biological activity. In the present study, we have consecutively extracted gonads of green sea urchins Strongylocentrotus droebachiensis from Barents Sea with chlo...
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Online Access: | https://cris.vtt.fi/en/publications/51d38e55-09ea-4afe-825a-9585990bd301 https://doi.org/10.1016/j.jff.2015.05.030 |
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ftvttcrispub:oai:cris.vtt.fi:publications/51d38e55-09ea-4afe-825a-9585990bd301 2024-09-15T17:57:49+00:00 Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea Pozharitskaya, Olga N. Shikov, Alexander N. Laakso, Into Seppänen-Laakso, Tuulikki Makarenko, Igor E. Faustova, Natalya M. Makarova, Marina N. Makarov, Valery G. 2015 https://cris.vtt.fi/en/publications/51d38e55-09ea-4afe-825a-9585990bd301 https://doi.org/10.1016/j.jff.2015.05.030 eng eng https://cris.vtt.fi/en/publications/51d38e55-09ea-4afe-825a-9585990bd301 info:eu-repo/semantics/closedAccess Pozharitskaya , O N , Shikov , A N , Laakso , I , Seppänen-Laakso , T , Makarenko , I E , Faustova , N M , Makarova , M N & Makarov , V G 2015 , ' Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea ' , Journal of Functional Foods , vol. 17 , pp. 227-234 . https://doi.org/10.1016/j.jff.2015.05.030 Strongylocentrotus droebachiensis Gonads Cyclooxygenase Diabetes Dipeptidyl peptidase IV Echinenone /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being article 2015 ftvttcrispub https://doi.org/10.1016/j.jff.2015.05.030 2024-07-10T23:32:17Z The gonads of sea urchins have been consumed by humans since ancient times. However, relatively little information is available on their biological activity. In the present study, we have consecutively extracted gonads of green sea urchins Strongylocentrotus droebachiensis from Barents Sea with chloroform-95% EtOH (4:1, v/v), (fraction ESD1), 95% EtOH (ESD2), and 70% EtOH (ESD3), characterized the fractions by GC-MS and HPLC, and further investigated their bioactivities. The cyclooxygenase-2 was inhibited by 62% with ESD1 and by 39% with ESD2. All the extracts from gonads significantly prevented the decrease in body weight of mice having streptozotocin-nicotinamide-induced (STZ/NA) diabetes. ESD2 significantly reduced serum glucose level in mice after 5 days of administration. The 50% inhibition of dipeptidyl peptidase IV was observed at a dose of 20 µg/ml of ESD2. These results suggest that sea urchin gonads may serve as a functional food for the management of inflammatory diseases and diabetes. Article in Journal/Newspaper Barents Sea VTT's Research Information Portal Journal of Functional Foods 17 227 234 |
institution |
Open Polar |
collection |
VTT's Research Information Portal |
op_collection_id |
ftvttcrispub |
language |
English |
topic |
Strongylocentrotus droebachiensis Gonads Cyclooxygenase Diabetes Dipeptidyl peptidase IV Echinenone /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
spellingShingle |
Strongylocentrotus droebachiensis Gonads Cyclooxygenase Diabetes Dipeptidyl peptidase IV Echinenone /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being Pozharitskaya, Olga N. Shikov, Alexander N. Laakso, Into Seppänen-Laakso, Tuulikki Makarenko, Igor E. Faustova, Natalya M. Makarova, Marina N. Makarov, Valery G. Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea |
topic_facet |
Strongylocentrotus droebachiensis Gonads Cyclooxygenase Diabetes Dipeptidyl peptidase IV Echinenone /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
description |
The gonads of sea urchins have been consumed by humans since ancient times. However, relatively little information is available on their biological activity. In the present study, we have consecutively extracted gonads of green sea urchins Strongylocentrotus droebachiensis from Barents Sea with chloroform-95% EtOH (4:1, v/v), (fraction ESD1), 95% EtOH (ESD2), and 70% EtOH (ESD3), characterized the fractions by GC-MS and HPLC, and further investigated their bioactivities. The cyclooxygenase-2 was inhibited by 62% with ESD1 and by 39% with ESD2. All the extracts from gonads significantly prevented the decrease in body weight of mice having streptozotocin-nicotinamide-induced (STZ/NA) diabetes. ESD2 significantly reduced serum glucose level in mice after 5 days of administration. The 50% inhibition of dipeptidyl peptidase IV was observed at a dose of 20 µg/ml of ESD2. These results suggest that sea urchin gonads may serve as a functional food for the management of inflammatory diseases and diabetes. |
format |
Article in Journal/Newspaper |
author |
Pozharitskaya, Olga N. Shikov, Alexander N. Laakso, Into Seppänen-Laakso, Tuulikki Makarenko, Igor E. Faustova, Natalya M. Makarova, Marina N. Makarov, Valery G. |
author_facet |
Pozharitskaya, Olga N. Shikov, Alexander N. Laakso, Into Seppänen-Laakso, Tuulikki Makarenko, Igor E. Faustova, Natalya M. Makarova, Marina N. Makarov, Valery G. |
author_sort |
Pozharitskaya, Olga N. |
title |
Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea |
title_short |
Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea |
title_full |
Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea |
title_fullStr |
Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea |
title_full_unstemmed |
Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea |
title_sort |
bioactivity and chemical characterization of gonads of green sea urchin strongylocentrotus droebachiensis from barents sea |
publishDate |
2015 |
url |
https://cris.vtt.fi/en/publications/51d38e55-09ea-4afe-825a-9585990bd301 https://doi.org/10.1016/j.jff.2015.05.030 |
genre |
Barents Sea |
genre_facet |
Barents Sea |
op_source |
Pozharitskaya , O N , Shikov , A N , Laakso , I , Seppänen-Laakso , T , Makarenko , I E , Faustova , N M , Makarova , M N & Makarov , V G 2015 , ' Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea ' , Journal of Functional Foods , vol. 17 , pp. 227-234 . https://doi.org/10.1016/j.jff.2015.05.030 |
op_relation |
https://cris.vtt.fi/en/publications/51d38e55-09ea-4afe-825a-9585990bd301 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.jff.2015.05.030 |
container_title |
Journal of Functional Foods |
container_volume |
17 |
container_start_page |
227 |
op_container_end_page |
234 |
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1810434013842636800 |