Central nervous system disease and genital disease in harbor porpoises ( Phocoena phocoena ) are associated with different herpesviruses
Herpesvirus infection causes disease of variable severity in many species, including cetaceans. However, little is known about herpesvirus infection in harbor porpoises ( Phocoena phocoena ), despite being widespread in temperate coastal waters of the Northern Hemisphere. Therefore, we examined harb...
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ftvliz:oai:oma.vliz.be:349565 2023-05-15T17:59:06+02:00 Central nervous system disease and genital disease in harbor porpoises ( Phocoena phocoena ) are associated with different herpesviruses van Elk, C. van de Bildt, M. van Run, P. de Jong, A. Getu, S. Verjans, G. Osterhaus, A. Kuiken, T. 2016 application/pdf https://www.vliz.be/imisdocs/publications/371847.pdf en eng info:eu-repo/semantics/altIdentifier/wos/000369569700005 info:eu-repo/semantics/altIdentifier/doi/doi.org/10.1186/s13567-016-0310-8 https://www.vliz.be/imisdocs/publications/371847.pdf info:eu-repo/semantics/openAccess %3Ci%3EVet.+Res.+47%281%29%3C%2Fi%3E%3A+28.+%3Ca+href%3D%22https%3A%2F%2Fdx.doi.org%2F10.1186%2Fs13567-016-0310-8%22+target%3D%22_blank%22%3Ehttps%3A%2F%2Fdx.doi.org%2F10.1186%2Fs13567-016-0310-8%3C%2Fa%3E Phocoena phocoena info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2016 ftvliz https://doi.org/10.1186/s13567-016-0310-8 2022-05-01T12:14:07Z Herpesvirus infection causes disease of variable severity in many species, including cetaceans. However, little is known about herpesvirus infection in harbor porpoises ( Phocoena phocoena ), despite being widespread in temperate coastal waters of the Northern Hemisphere. Therefore, we examined harbor porpoises that stranded alive in the Netherlands, Belgium, and Germany between 2000 and 2014 for herpesvirus infection and associated disease. Porpoises that died or had to be euthanized were autopsied, and samples were collected for virological and pathological analyses. We found one known herpesvirus ( Phocoena phocoena herpesvirus type 1, PPHV-1)—a gammaherpesvirus—and two novel herpesviruses (PPHV-2 and PPHV-3)—both alphaherpesviruses—in these porpoises. A genital plaque, in which PPHV-1 was detected, occurred in 1% (1/117) of porpoises. The plaque was characterized by epithelial hyperplasia and intranuclear inclusion bodies that contained herpesvirus-like particles, and that stained positive by a PPHV-1-specific in situ hybridization test. PPHV-2 occurred in the brain of 2% (1/74) of porpoises. This infection was associated with lymphocytic encephalitis, characterized by neuronal necrosis and intranuclear inclusion bodies containing herpesvirus-like particles. PPHV-3 had a prevalence of 5% (4/74) in brain tissue, 5% (2/43) in blowhole swabs, and 2% (1/43) in genital swabs, but was not associated with disease. Phylogenetically, PPHV-1 was identical to a previously reported herpesvirus from a harbor porpoise, PPHV-2 showed closest identity with two herpesviruses from dolphins, and PPHV-3 showed closest identity with a cervid herpesvirus. In conclusion, harbor porpoises may be infected with at least three different herpesviruses, one of which can cause clinically severe neurological disease. Article in Journal/Newspaper Phocoena phocoena Flanders Marine Institute (VLIZ): Open Marine Archive (OMA) Veterinary Research 47 1 |
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Open Polar |
collection |
Flanders Marine Institute (VLIZ): Open Marine Archive (OMA) |
op_collection_id |
ftvliz |
language |
English |
topic |
Phocoena phocoena |
spellingShingle |
Phocoena phocoena van Elk, C. van de Bildt, M. van Run, P. de Jong, A. Getu, S. Verjans, G. Osterhaus, A. Kuiken, T. Central nervous system disease and genital disease in harbor porpoises ( Phocoena phocoena ) are associated with different herpesviruses |
topic_facet |
Phocoena phocoena |
description |
Herpesvirus infection causes disease of variable severity in many species, including cetaceans. However, little is known about herpesvirus infection in harbor porpoises ( Phocoena phocoena ), despite being widespread in temperate coastal waters of the Northern Hemisphere. Therefore, we examined harbor porpoises that stranded alive in the Netherlands, Belgium, and Germany between 2000 and 2014 for herpesvirus infection and associated disease. Porpoises that died or had to be euthanized were autopsied, and samples were collected for virological and pathological analyses. We found one known herpesvirus ( Phocoena phocoena herpesvirus type 1, PPHV-1)—a gammaherpesvirus—and two novel herpesviruses (PPHV-2 and PPHV-3)—both alphaherpesviruses—in these porpoises. A genital plaque, in which PPHV-1 was detected, occurred in 1% (1/117) of porpoises. The plaque was characterized by epithelial hyperplasia and intranuclear inclusion bodies that contained herpesvirus-like particles, and that stained positive by a PPHV-1-specific in situ hybridization test. PPHV-2 occurred in the brain of 2% (1/74) of porpoises. This infection was associated with lymphocytic encephalitis, characterized by neuronal necrosis and intranuclear inclusion bodies containing herpesvirus-like particles. PPHV-3 had a prevalence of 5% (4/74) in brain tissue, 5% (2/43) in blowhole swabs, and 2% (1/43) in genital swabs, but was not associated with disease. Phylogenetically, PPHV-1 was identical to a previously reported herpesvirus from a harbor porpoise, PPHV-2 showed closest identity with two herpesviruses from dolphins, and PPHV-3 showed closest identity with a cervid herpesvirus. In conclusion, harbor porpoises may be infected with at least three different herpesviruses, one of which can cause clinically severe neurological disease. |
format |
Article in Journal/Newspaper |
author |
van Elk, C. van de Bildt, M. van Run, P. de Jong, A. Getu, S. Verjans, G. Osterhaus, A. Kuiken, T. |
author_facet |
van Elk, C. van de Bildt, M. van Run, P. de Jong, A. Getu, S. Verjans, G. Osterhaus, A. Kuiken, T. |
author_sort |
van Elk, C. |
title |
Central nervous system disease and genital disease in harbor porpoises ( Phocoena phocoena ) are associated with different herpesviruses |
title_short |
Central nervous system disease and genital disease in harbor porpoises ( Phocoena phocoena ) are associated with different herpesviruses |
title_full |
Central nervous system disease and genital disease in harbor porpoises ( Phocoena phocoena ) are associated with different herpesviruses |
title_fullStr |
Central nervous system disease and genital disease in harbor porpoises ( Phocoena phocoena ) are associated with different herpesviruses |
title_full_unstemmed |
Central nervous system disease and genital disease in harbor porpoises ( Phocoena phocoena ) are associated with different herpesviruses |
title_sort |
central nervous system disease and genital disease in harbor porpoises ( phocoena phocoena ) are associated with different herpesviruses |
publishDate |
2016 |
url |
https://www.vliz.be/imisdocs/publications/371847.pdf |
genre |
Phocoena phocoena |
genre_facet |
Phocoena phocoena |
op_source |
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op_relation |
info:eu-repo/semantics/altIdentifier/wos/000369569700005 info:eu-repo/semantics/altIdentifier/doi/doi.org/10.1186/s13567-016-0310-8 https://www.vliz.be/imisdocs/publications/371847.pdf |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1186/s13567-016-0310-8 |
container_title |
Veterinary Research |
container_volume |
47 |
container_issue |
1 |
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1766167847943274496 |