Residue levels of enrofloxacin and ciprofloxacin in processed animal by-products used in Atlantic salmon feeds and their long-term carry-over to the edible part of the fish
Residue levels of the antibacterials enrofloxacin and ciprofloxacin were analysed in 15 commercially relevant animal by-products (ABPs). Enrofloxacin was detected in all ABPs, and ciprofloxacin was detected in 11 of 15 ABP samples. Feed to muscle and skin carry –over of low background enro- and cipr...
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ftvliz:oai:oma.vliz.be:246833 2023-05-15T15:31:34+02:00 Residue levels of enrofloxacin and ciprofloxacin in processed animal by-products used in Atlantic salmon feeds and their long-term carry-over to the edible part of the fish Berntssen, G Valdersnes, S Lunestad, T Hatlen, B Alm, M. Waagbo, R Buttle, L 2014 http://www.vliz.be/nl/open-marien-archief?module=ref&refid=246833 en eng info:eu-repo/semantics/altIdentifier/wos/000345077300014 info:eu-repo/semantics/altIdentifier/doi/doi.org/10.1111/anu.12121 http://www.vliz.be/nl/open-marien-archief?module=ref&refid=246833 info:eu-repo/semantics/restrictedAccess %3Ci%3EAquacult.+Nutr.+20%286%29%3C%2Fi%3E%3A+712-721.+%3Ca+href%3D%22https%3A%2F%2Fdx.doi.org%2F10.1111%2Fanu.12121%22+target%3D%22_blank%22%3Ehttps%3A%2F%2Fdx.doi.org%2F10.1111%2Fanu.12121%3C%2Fa%3E Salmo salar Linnaeus 1758 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2014 ftvliz https://doi.org/10.1111/anu.12121 2022-05-01T10:26:15Z Residue levels of the antibacterials enrofloxacin and ciprofloxacin were analysed in 15 commercially relevant animal by-products (ABPs). Enrofloxacin was detected in all ABPs, and ciprofloxacin was detected in 11 of 15 ABP samples. Feed to muscle and skin carry –over of low background enro- and ciprofloxacin levels were assessed by applying a simple toxicokinetic model. The muscle and skin uptake and elimination rates were established in Atlantic salmon ( Salmo salar L.) fed enrofloxacin enriched diets (100 µg kg -1 ‘low’ and 4000 µg kg -1 ‘high’) in triplicate for 41 days followed by a 90 days depuration period. The terminal half-lives were 17 ± 0.4 and 18 ± 0.7 days, and uptake rates were 9.3 ± 3.3 and 11 ± 3.1 (day -1 ) for the ‘low’ and ‘high’ groups, respectively. Only fish fed high background levels had quantifiable levels of the metabolite ciprofloxacin with a formation of 0.25 ± 0.01% day -1 . The toxicokinetic carry-over model predicted muscle and skin steady state levels of 1.8 µg kg -1 when fed theoretically high enrofloxacin levels (158 µg kg -1 ), which is below the EU limit of 100 µg kg -1 for enrofloxacin in finfish food products. The antibacterial residue levels could however be detected in EU food surveillance programmes. Article in Journal/Newspaper Atlantic salmon Salmo salar Flanders Marine Institute (VLIZ): Open Marine Archive (OMA) Aquaculture Nutrition 20 6 712 721 |
institution |
Open Polar |
collection |
Flanders Marine Institute (VLIZ): Open Marine Archive (OMA) |
op_collection_id |
ftvliz |
language |
English |
topic |
Salmo salar Linnaeus 1758 |
spellingShingle |
Salmo salar Linnaeus 1758 Berntssen, G Valdersnes, S Lunestad, T Hatlen, B Alm, M. Waagbo, R Buttle, L Residue levels of enrofloxacin and ciprofloxacin in processed animal by-products used in Atlantic salmon feeds and their long-term carry-over to the edible part of the fish |
topic_facet |
Salmo salar Linnaeus 1758 |
description |
Residue levels of the antibacterials enrofloxacin and ciprofloxacin were analysed in 15 commercially relevant animal by-products (ABPs). Enrofloxacin was detected in all ABPs, and ciprofloxacin was detected in 11 of 15 ABP samples. Feed to muscle and skin carry –over of low background enro- and ciprofloxacin levels were assessed by applying a simple toxicokinetic model. The muscle and skin uptake and elimination rates were established in Atlantic salmon ( Salmo salar L.) fed enrofloxacin enriched diets (100 µg kg -1 ‘low’ and 4000 µg kg -1 ‘high’) in triplicate for 41 days followed by a 90 days depuration period. The terminal half-lives were 17 ± 0.4 and 18 ± 0.7 days, and uptake rates were 9.3 ± 3.3 and 11 ± 3.1 (day -1 ) for the ‘low’ and ‘high’ groups, respectively. Only fish fed high background levels had quantifiable levels of the metabolite ciprofloxacin with a formation of 0.25 ± 0.01% day -1 . The toxicokinetic carry-over model predicted muscle and skin steady state levels of 1.8 µg kg -1 when fed theoretically high enrofloxacin levels (158 µg kg -1 ), which is below the EU limit of 100 µg kg -1 for enrofloxacin in finfish food products. The antibacterial residue levels could however be detected in EU food surveillance programmes. |
format |
Article in Journal/Newspaper |
author |
Berntssen, G Valdersnes, S Lunestad, T Hatlen, B Alm, M. Waagbo, R Buttle, L |
author_facet |
Berntssen, G Valdersnes, S Lunestad, T Hatlen, B Alm, M. Waagbo, R Buttle, L |
author_sort |
Berntssen, G |
title |
Residue levels of enrofloxacin and ciprofloxacin in processed animal by-products used in Atlantic salmon feeds and their long-term carry-over to the edible part of the fish |
title_short |
Residue levels of enrofloxacin and ciprofloxacin in processed animal by-products used in Atlantic salmon feeds and their long-term carry-over to the edible part of the fish |
title_full |
Residue levels of enrofloxacin and ciprofloxacin in processed animal by-products used in Atlantic salmon feeds and their long-term carry-over to the edible part of the fish |
title_fullStr |
Residue levels of enrofloxacin and ciprofloxacin in processed animal by-products used in Atlantic salmon feeds and their long-term carry-over to the edible part of the fish |
title_full_unstemmed |
Residue levels of enrofloxacin and ciprofloxacin in processed animal by-products used in Atlantic salmon feeds and their long-term carry-over to the edible part of the fish |
title_sort |
residue levels of enrofloxacin and ciprofloxacin in processed animal by-products used in atlantic salmon feeds and their long-term carry-over to the edible part of the fish |
publishDate |
2014 |
url |
http://www.vliz.be/nl/open-marien-archief?module=ref&refid=246833 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
%3Ci%3EAquacult.+Nutr.+20%286%29%3C%2Fi%3E%3A+712-721.+%3Ca+href%3D%22https%3A%2F%2Fdx.doi.org%2F10.1111%2Fanu.12121%22+target%3D%22_blank%22%3Ehttps%3A%2F%2Fdx.doi.org%2F10.1111%2Fanu.12121%3C%2Fa%3E |
op_relation |
info:eu-repo/semantics/altIdentifier/wos/000345077300014 info:eu-repo/semantics/altIdentifier/doi/doi.org/10.1111/anu.12121 http://www.vliz.be/nl/open-marien-archief?module=ref&refid=246833 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1111/anu.12121 |
container_title |
Aquaculture Nutrition |
container_volume |
20 |
container_issue |
6 |
container_start_page |
712 |
op_container_end_page |
721 |
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1766362094697971712 |