Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon ( Salmo salar ) postsmolts
Inflammation is a non-specific protective mechanism towards injury known to affect bone remodelling. This study aimed to investigate the effect of Freund’s complete adjuvant (FCA) induced-inflammation on the prevalence of spinal deformities of Atlantic salmon postsmolts fed with two different dietar...
Published in: | Aquaculture Nutrition |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2012
|
Subjects: | |
Online Access: | http://www.vliz.be/nl/open-marien-archief?module=ref&refid=238575 |
id |
ftvliz:oai:oma.vliz.be:238575 |
---|---|
record_format |
openpolar |
spelling |
ftvliz:oai:oma.vliz.be:238575 2023-05-15T15:30:46+02:00 Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon ( Salmo salar ) postsmolts Martens, L.G. Fjelldal, P.G. Lock, E.J. Wargelius, A. Wergeland, H. Witten, P.E. Hansen, T. Waagbo, R. Ornsrud, R. 2012 http://www.vliz.be/nl/open-marien-archief?module=ref&refid=238575 en eng info:eu-repo/semantics/altIdentifier/wos/000298913700002 info:eu-repo/semantics/altIdentifier/doi/doi.org/10.1111/j.1365-2095.2011.00871.x http://www.vliz.be/nl/open-marien-archief?module=ref&refid=238575 info:eu-repo/semantics/restrictedAccess %3Ci%3EAquacult.+Nutr.+18%281%29%3C%2Fi%3E%3A+12-20.+%3Ca+href%3D%22https%3A%2F%2Fdx.doi.org%2F10.1111%2Fj.1365-2095.2011.00871.x%22+target%3D%22_blank%22%3Ehttps%3A%2F%2Fdx.doi.org%2F10.1111%2Fj.1365-2095.2011.00871.x%3C%2Fa%3E Salmo salar Linnaeus 1758 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2012 ftvliz https://doi.org/10.1111/j.1365-2095.2011.00871.x 2022-05-01T10:16:05Z Inflammation is a non-specific protective mechanism towards injury known to affect bone remodelling. This study aimed to investigate the effect of Freund’s complete adjuvant (FCA) induced-inflammation on the prevalence of spinal deformities of Atlantic salmon postsmolts fed with two different dietary P levels. Sextuple groups of salmon postsmolts were fed with either a low-phosphorous (6 g kg -1 available P, LP) or a high-phosphorous (9 g kg -1 available P) diet for a period of 101 days. On Day 102, individually tagged fish were subjected to (i) single injection with FCA (0.125 mg kg -1 BW) dissolved in phosphate-buffered saline (PBS) (ii) placebo injection with PBS or (iii) sham injection (insertion of needle only) or (iv) remained untreated. On Day 103, fish were given a common diet for 174 days in seawater. No significant differences in body weight were observed. Injected fish, particularly the FCA group, had more compressions in the injection site than untreated fish. No effect of diet and no interaction between treatment and diet were observed. Severe scoliosis was observed in ~7% of FCA-injected individuals, corresponding to a mixture of bone malformations in the tail region. In conclusion, experimentally induced inflammation may be an independent risk factor for bone deformities in Atlantic salmon. Article in Journal/Newspaper Atlantic salmon Salmo salar Flanders Marine Institute (VLIZ): Open Marine Archive (OMA) Aquaculture Nutrition 18 1 12 20 |
institution |
Open Polar |
collection |
Flanders Marine Institute (VLIZ): Open Marine Archive (OMA) |
op_collection_id |
ftvliz |
language |
English |
topic |
Salmo salar Linnaeus 1758 |
spellingShingle |
Salmo salar Linnaeus 1758 Martens, L.G. Fjelldal, P.G. Lock, E.J. Wargelius, A. Wergeland, H. Witten, P.E. Hansen, T. Waagbo, R. Ornsrud, R. Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon ( Salmo salar ) postsmolts |
topic_facet |
Salmo salar Linnaeus 1758 |
description |
Inflammation is a non-specific protective mechanism towards injury known to affect bone remodelling. This study aimed to investigate the effect of Freund’s complete adjuvant (FCA) induced-inflammation on the prevalence of spinal deformities of Atlantic salmon postsmolts fed with two different dietary P levels. Sextuple groups of salmon postsmolts were fed with either a low-phosphorous (6 g kg -1 available P, LP) or a high-phosphorous (9 g kg -1 available P) diet for a period of 101 days. On Day 102, individually tagged fish were subjected to (i) single injection with FCA (0.125 mg kg -1 BW) dissolved in phosphate-buffered saline (PBS) (ii) placebo injection with PBS or (iii) sham injection (insertion of needle only) or (iv) remained untreated. On Day 103, fish were given a common diet for 174 days in seawater. No significant differences in body weight were observed. Injected fish, particularly the FCA group, had more compressions in the injection site than untreated fish. No effect of diet and no interaction between treatment and diet were observed. Severe scoliosis was observed in ~7% of FCA-injected individuals, corresponding to a mixture of bone malformations in the tail region. In conclusion, experimentally induced inflammation may be an independent risk factor for bone deformities in Atlantic salmon. |
format |
Article in Journal/Newspaper |
author |
Martens, L.G. Fjelldal, P.G. Lock, E.J. Wargelius, A. Wergeland, H. Witten, P.E. Hansen, T. Waagbo, R. Ornsrud, R. |
author_facet |
Martens, L.G. Fjelldal, P.G. Lock, E.J. Wargelius, A. Wergeland, H. Witten, P.E. Hansen, T. Waagbo, R. Ornsrud, R. |
author_sort |
Martens, L.G. |
title |
Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon ( Salmo salar ) postsmolts |
title_short |
Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon ( Salmo salar ) postsmolts |
title_full |
Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon ( Salmo salar ) postsmolts |
title_fullStr |
Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon ( Salmo salar ) postsmolts |
title_full_unstemmed |
Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon ( Salmo salar ) postsmolts |
title_sort |
dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in atlantic salmon ( salmo salar ) postsmolts |
publishDate |
2012 |
url |
http://www.vliz.be/nl/open-marien-archief?module=ref&refid=238575 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
%3Ci%3EAquacult.+Nutr.+18%281%29%3C%2Fi%3E%3A+12-20.+%3Ca+href%3D%22https%3A%2F%2Fdx.doi.org%2F10.1111%2Fj.1365-2095.2011.00871.x%22+target%3D%22_blank%22%3Ehttps%3A%2F%2Fdx.doi.org%2F10.1111%2Fj.1365-2095.2011.00871.x%3C%2Fa%3E |
op_relation |
info:eu-repo/semantics/altIdentifier/wos/000298913700002 info:eu-repo/semantics/altIdentifier/doi/doi.org/10.1111/j.1365-2095.2011.00871.x http://www.vliz.be/nl/open-marien-archief?module=ref&refid=238575 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1111/j.1365-2095.2011.00871.x |
container_title |
Aquaculture Nutrition |
container_volume |
18 |
container_issue |
1 |
container_start_page |
12 |
op_container_end_page |
20 |
_version_ |
1766361222656032768 |