Physiologically based pharmacokinetic (PBPK) models for lifetime exposure to PCB 153 in male and female harbor porpoises ( Phocoena phocoena ): model development and evaluation
Physiologically based pharmacokinetic (PBPK) models were developed for the most persistent polychlorinated biphenyl (PCB 153) in male and female harbor porpoises ( Phocoena phocoena ) to elucidate processes such as uptake, distribution, and elimination. Due to its limited metabolic capacities, long...
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ftvliz:oai:oma.vliz.be:199066 2023-05-15T17:59:08+02:00 Physiologically based pharmacokinetic (PBPK) models for lifetime exposure to PCB 153 in male and female harbor porpoises ( Phocoena phocoena ): model development and evaluation Weijs, L. Yang, R.S.H. Covaci, A. Das, K. Blust, R. 2010 http://www.vliz.be/nl/open-marien-archief?module=ref&refid=199066 en eng info:eu-repo/semantics/altIdentifier/wos/000281629800021 info:eu-repo/semantics/altIdentifier/doi/doi.org/10.1021/es101688h http://www.vliz.be/nl/open-marien-archief?module=ref&refid=199066 info:eu-repo/semantics/restrictedAccess %3Ci%3EEnviron.+Sci.+Technol.+44%2818%29%3C%2Fi%3E%3A+7023-7030.+%3Ca+href%3D%22https%3A%2F%2Fdx.doi.org%2F10.1021%2Fes101688h%22+target%3D%22_blank%22%3Ehttps%3A%2F%2Fdx.doi.org%2F10.1021%2Fes101688h%3C%2Fa%3E info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2010 ftvliz https://doi.org/10.1021/es101688h 2022-05-01T09:21:42Z Physiologically based pharmacokinetic (PBPK) models were developed for the most persistent polychlorinated biphenyl (PCB 153) in male and female harbor porpoises ( Phocoena phocoena ) to elucidate processes such as uptake, distribution, and elimination. Due to its limited metabolic capacities, long life span, and top position in marine food chains, this species is highly sensitive to pollution. The models consist of 5 compartments, liver, blubber, kidney, brain, and a compartment which accounts for the rest of the body, all connected through blood. All physiological and biochemical parameters were extracted from the literature, except for the brain/blood partition coefficient and rate of excretion, which were both fitted to data sets used for validation of the models. These data sets were compiled from our own analyses performed with GC-MS on tissue samples of harbor porpoises. The intake of PCB 153 was from milk from birth to 4 months, and after weaning fish was the main food source. Overall, these models reveal that concentrations of PCB 153 in males increase with age but suggest that, as the animals grow older, metabolic transformation can be a possible pathway for elimination as well. In contrast, the model for females confirms that gestation and lactation are key processes for eliminating PCB 153 as body burdens decrease with age. These PBPK models are capable of simulating the bioaccumulation of PCB 153 during the entire life span of approximately 20 years of the harbor porpoises. Article in Journal/Newspaper Phocoena phocoena Flanders Marine Institute (VLIZ): Open Marine Archive (OMA) Environmental Science & Technology 44 18 7023 7030 |
institution |
Open Polar |
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Flanders Marine Institute (VLIZ): Open Marine Archive (OMA) |
op_collection_id |
ftvliz |
language |
English |
description |
Physiologically based pharmacokinetic (PBPK) models were developed for the most persistent polychlorinated biphenyl (PCB 153) in male and female harbor porpoises ( Phocoena phocoena ) to elucidate processes such as uptake, distribution, and elimination. Due to its limited metabolic capacities, long life span, and top position in marine food chains, this species is highly sensitive to pollution. The models consist of 5 compartments, liver, blubber, kidney, brain, and a compartment which accounts for the rest of the body, all connected through blood. All physiological and biochemical parameters were extracted from the literature, except for the brain/blood partition coefficient and rate of excretion, which were both fitted to data sets used for validation of the models. These data sets were compiled from our own analyses performed with GC-MS on tissue samples of harbor porpoises. The intake of PCB 153 was from milk from birth to 4 months, and after weaning fish was the main food source. Overall, these models reveal that concentrations of PCB 153 in males increase with age but suggest that, as the animals grow older, metabolic transformation can be a possible pathway for elimination as well. In contrast, the model for females confirms that gestation and lactation are key processes for eliminating PCB 153 as body burdens decrease with age. These PBPK models are capable of simulating the bioaccumulation of PCB 153 during the entire life span of approximately 20 years of the harbor porpoises. |
format |
Article in Journal/Newspaper |
author |
Weijs, L. Yang, R.S.H. Covaci, A. Das, K. Blust, R. |
spellingShingle |
Weijs, L. Yang, R.S.H. Covaci, A. Das, K. Blust, R. Physiologically based pharmacokinetic (PBPK) models for lifetime exposure to PCB 153 in male and female harbor porpoises ( Phocoena phocoena ): model development and evaluation |
author_facet |
Weijs, L. Yang, R.S.H. Covaci, A. Das, K. Blust, R. |
author_sort |
Weijs, L. |
title |
Physiologically based pharmacokinetic (PBPK) models for lifetime exposure to PCB 153 in male and female harbor porpoises ( Phocoena phocoena ): model development and evaluation |
title_short |
Physiologically based pharmacokinetic (PBPK) models for lifetime exposure to PCB 153 in male and female harbor porpoises ( Phocoena phocoena ): model development and evaluation |
title_full |
Physiologically based pharmacokinetic (PBPK) models for lifetime exposure to PCB 153 in male and female harbor porpoises ( Phocoena phocoena ): model development and evaluation |
title_fullStr |
Physiologically based pharmacokinetic (PBPK) models for lifetime exposure to PCB 153 in male and female harbor porpoises ( Phocoena phocoena ): model development and evaluation |
title_full_unstemmed |
Physiologically based pharmacokinetic (PBPK) models for lifetime exposure to PCB 153 in male and female harbor porpoises ( Phocoena phocoena ): model development and evaluation |
title_sort |
physiologically based pharmacokinetic (pbpk) models for lifetime exposure to pcb 153 in male and female harbor porpoises ( phocoena phocoena ): model development and evaluation |
publishDate |
2010 |
url |
http://www.vliz.be/nl/open-marien-archief?module=ref&refid=199066 |
genre |
Phocoena phocoena |
genre_facet |
Phocoena phocoena |
op_source |
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op_relation |
info:eu-repo/semantics/altIdentifier/wos/000281629800021 info:eu-repo/semantics/altIdentifier/doi/doi.org/10.1021/es101688h http://www.vliz.be/nl/open-marien-archief?module=ref&refid=199066 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1021/es101688h |
container_title |
Environmental Science & Technology |
container_volume |
44 |
container_issue |
18 |
container_start_page |
7023 |
op_container_end_page |
7030 |
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1766167894845030400 |