Lipase B from Candida antarctica — the wide applicable biocatalyst in obtaining pharmaceutical compounds
Lipases are commonly applied in the pharmaceutical and chemical industry, especially in immobilizedform. The use of immobilized lipases facilitates the design of reactors and control of reactions, for example,fast stopping the reaction. The immobilization procedure should increase the stability of t...
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ftviamedicaojs:oai:czasopisma.viamedica.pl:article/64839 2023-05-15T13:44:34+02:00 Lipase B from Candida antarctica — the wide applicable biocatalyst in obtaining pharmaceutical compounds Dulęba, Jacek Czirson, Katarzyna Siódmiak, Tomasz Marszałł, Michał Piotr 2019-10-17 application/pdf https://journals.viamedica.pl/medical_research_journal/article/view/MRJ.a2019.0030 https://doi.org/10.5603/MRJ.a2019.0030 en eng Via Medica Completion of the online submission form electronically is tantamount to automatically and free-of-charge transferring of the copyright for publishing and distribution of the submitted material (in all known now and developed in the future forms and fields of exploitation) to the Publisher, under condition that those materials are accepted for publication. The authors agree not to publish any data or figures presented in their work anywhere and in any language without the prior written consent of the owner of the copyrights, i.e. the Publisher. Medical Research Journal; Vol 4, No 3 (2019); 174-177 lipase B from Candida antarctica immobilization triglycerides interfacial activation kinetic resolution transesterification acylation 2019 ftviamedicaojs https://doi.org/10.5603/MRJ.a2019.0030 2019-10-22T14:58:48Z Lipases are commonly applied in the pharmaceutical and chemical industry, especially in immobilizedform. The use of immobilized lipases facilitates the design of reactors and control of reactions, for example,fast stopping the reaction. The immobilization procedure should increase the stability of the lipaseand its activity, as well as be simple and efficient. Lipase B from Candida antarctica (CAL-B) is an enzymefrom the lipase group, isolated from the Candida antarctica species. CAL-B has the highest activity innon-polar organic solvents, such as hexane and toluene, and the lowest in polar solvents, e.g. acetonitrile.Due to its hydrolytic properties, this enzyme degrades triglycerides of fatty acids to free fatty acids (FFA)and glycerol. Described lipase is often immobilized, in the aim to increase enantioselective and lipolyticactivity. The kinetic and dynamic resolution with the application of lipase is one of the ways in obtainingan enantiopure form of the drugs, which usually are more effective and safer for the patient. The CAL-Bcould be also applied in the kinetic resolution of compounds being building blocks, derivates of drugs orconjugated forms. Furthermore, the CAL-B is used in the reactions in receiving of organic compounds,which are the natural origin, especially vegetable. Based on the presented data, it can be concluded, thatCAL-B is an enzyme with a wide application in the biosynthesis of compounds with therapeutic activity. Other/Unknown Material Antarc* Antarctica Via Medica Journals Medical Research Journal 4 3 174 177 |
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Via Medica Journals |
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English |
topic |
lipase B from Candida antarctica immobilization triglycerides interfacial activation kinetic resolution transesterification acylation |
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lipase B from Candida antarctica immobilization triglycerides interfacial activation kinetic resolution transesterification acylation Dulęba, Jacek Czirson, Katarzyna Siódmiak, Tomasz Marszałł, Michał Piotr Lipase B from Candida antarctica — the wide applicable biocatalyst in obtaining pharmaceutical compounds |
topic_facet |
lipase B from Candida antarctica immobilization triglycerides interfacial activation kinetic resolution transesterification acylation |
description |
Lipases are commonly applied in the pharmaceutical and chemical industry, especially in immobilizedform. The use of immobilized lipases facilitates the design of reactors and control of reactions, for example,fast stopping the reaction. The immobilization procedure should increase the stability of the lipaseand its activity, as well as be simple and efficient. Lipase B from Candida antarctica (CAL-B) is an enzymefrom the lipase group, isolated from the Candida antarctica species. CAL-B has the highest activity innon-polar organic solvents, such as hexane and toluene, and the lowest in polar solvents, e.g. acetonitrile.Due to its hydrolytic properties, this enzyme degrades triglycerides of fatty acids to free fatty acids (FFA)and glycerol. Described lipase is often immobilized, in the aim to increase enantioselective and lipolyticactivity. The kinetic and dynamic resolution with the application of lipase is one of the ways in obtainingan enantiopure form of the drugs, which usually are more effective and safer for the patient. The CAL-Bcould be also applied in the kinetic resolution of compounds being building blocks, derivates of drugs orconjugated forms. Furthermore, the CAL-B is used in the reactions in receiving of organic compounds,which are the natural origin, especially vegetable. Based on the presented data, it can be concluded, thatCAL-B is an enzyme with a wide application in the biosynthesis of compounds with therapeutic activity. |
author |
Dulęba, Jacek Czirson, Katarzyna Siódmiak, Tomasz Marszałł, Michał Piotr |
author_facet |
Dulęba, Jacek Czirson, Katarzyna Siódmiak, Tomasz Marszałł, Michał Piotr |
author_sort |
Dulęba, Jacek |
title |
Lipase B from Candida antarctica — the wide applicable biocatalyst in obtaining pharmaceutical compounds |
title_short |
Lipase B from Candida antarctica — the wide applicable biocatalyst in obtaining pharmaceutical compounds |
title_full |
Lipase B from Candida antarctica — the wide applicable biocatalyst in obtaining pharmaceutical compounds |
title_fullStr |
Lipase B from Candida antarctica — the wide applicable biocatalyst in obtaining pharmaceutical compounds |
title_full_unstemmed |
Lipase B from Candida antarctica — the wide applicable biocatalyst in obtaining pharmaceutical compounds |
title_sort |
lipase b from candida antarctica — the wide applicable biocatalyst in obtaining pharmaceutical compounds |
publisher |
Via Medica |
publishDate |
2019 |
url |
https://journals.viamedica.pl/medical_research_journal/article/view/MRJ.a2019.0030 https://doi.org/10.5603/MRJ.a2019.0030 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Medical Research Journal; Vol 4, No 3 (2019); 174-177 |
op_rights |
Completion of the online submission form electronically is tantamount to automatically and free-of-charge transferring of the copyright for publishing and distribution of the submitted material (in all known now and developed in the future forms and fields of exploitation) to the Publisher, under condition that those materials are accepted for publication. The authors agree not to publish any data or figures presented in their work anywhere and in any language without the prior written consent of the owner of the copyrights, i.e. the Publisher. |
op_doi |
https://doi.org/10.5603/MRJ.a2019.0030 |
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Medical Research Journal |
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4 |
container_issue |
3 |
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174 |
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177 |
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