Biosynthetic potential of uncultured Antarctic soil bacteria revealed through long-read metagenomic sequencing

• Published in: The ISME Journal
• Main Authors: Waschulin, Valentin, Borsetto, Chiara, James, Robert, Newsham, Kevin K., Donadio, Stefano, Corre, Christophe, Wellington, Elizabeth M. H.
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: Nature Publishing Group 2022
• Subjects: QH Natural history; QR Microbiology; Antarctic; Mars Oasis; Antarc*; Antarctica
• Online Access: http://wrap.warwick.ac.uk/155929/; http://wrap.warwick.ac.uk/155929/1/WRAP-biosynthetic-potential-uncultured-Antarctic-soil-bacteria-revealed-through-long-read-metagenomic-sequencing-2021.pdf; https://doi.org/10.1038/s41396-021-01052-3

The growing problem of antibiotic resistance has led to the exploration of uncultured bacteria as potential sources of new antimicrobials. PCR amplicon analyses and short-read sequencing studies of samples from different environments have reported evidence of high biosynthetic gene cluster (BGC) div...