Gestational diabetes, but not pre-pregnancy overweight predicts cardio-metabolic markers in offspring twenty years later
Context Maternal gestational diabetes (GDM) and pre-pregnancy overweight/obesity (body mass index, BMI ≥25kg/m2) may adversely affect offspring cardio-metabolic health. Objective To assess associations of maternal GDM and pre-pregnancy overweight/obesity with adult offspring cardio-metabolic risk fa...
Published in: | The Journal of Clinical Endocrinology & Metabolism |
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Main Authors: | , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
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The Endocrine Society
2019
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Online Access: | http://wrap.warwick.ac.uk/114965/ http://wrap.warwick.ac.uk/114965/1/WRAP-Gestational-diabetes-pre-pregnancy-overweight-predicts-cardio-metabolic-Wolke-2019.pdf http://wrap.warwick.ac.uk/114965/2/WRAP-supplementary_tables_1-4.pdf http://wrap.warwick.ac.uk/114965/3/WRAP-figure_1_flow_chart_of_the_study_population.pptx http://wrap.warwick.ac.uk/114965/4/WRAP-tables_1-3.pdf https://doi.org/10.1210/jc.2018-02743 |
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ftuwarwick:oai:wrap.warwick.ac.uk:114965 2023-05-15T17:42:43+02:00 Gestational diabetes, but not pre-pregnancy overweight predicts cardio-metabolic markers in offspring twenty years later Kaseva, Nina Vääräsmäki, Marja Sundvall, Jouko Matinolli, Hanna-Maria Sipola, Marika Tikanmäki, Marjaana Heinonen, Kati Lano, Aulikki Wehkalampi, Karoliina Wolke, Dieter Ruokonen, Aimo Andersson, Sture Järvelin, Marjo-Riitta Räikkönen, Katri Eriksson, Johan G. Kajantie, Eero 2019-07 application/pdf other http://wrap.warwick.ac.uk/114965/ http://wrap.warwick.ac.uk/114965/1/WRAP-Gestational-diabetes-pre-pregnancy-overweight-predicts-cardio-metabolic-Wolke-2019.pdf http://wrap.warwick.ac.uk/114965/2/WRAP-supplementary_tables_1-4.pdf http://wrap.warwick.ac.uk/114965/3/WRAP-figure_1_flow_chart_of_the_study_population.pptx http://wrap.warwick.ac.uk/114965/4/WRAP-tables_1-3.pdf https://doi.org/10.1210/jc.2018-02743 unknown The Endocrine Society http://wrap.warwick.ac.uk/114965/1/WRAP-Gestational-diabetes-pre-pregnancy-overweight-predicts-cardio-metabolic-Wolke-2019.pdf http://wrap.warwick.ac.uk/114965/2/WRAP-supplementary_tables_1-4.pdf http://wrap.warwick.ac.uk/114965/3/WRAP-figure_1_flow_chart_of_the_study_population.pptx http://wrap.warwick.ac.uk/114965/4/WRAP-tables_1-3.pdf Kaseva, Nina, Vääräsmäki, Marja, Sundvall, Jouko, Matinolli, Hanna-Maria, Sipola, Marika, Tikanmäki, Marjaana, Heinonen, Kati, Lano, Aulikki, Wehkalampi, Karoliina, Wolke, Dieter, Ruokonen, Aimo, Andersson, Sture, Järvelin, Marjo-Riitta, Räikkönen, Katri, Eriksson, Johan G. and Kajantie, Eero (2019) Gestational diabetes, but not pre-pregnancy overweight predicts cardio-metabolic markers in offspring twenty years later. Journal of Clinical Endocrinology & Metabolism, 104 (7). pp. 2785-2795. doi:10.1210/jc.2018-02743 <http://dx.doi.org/10.1210/jc.2018-02743> RG Gynecology and obstetrics Journal Article NonPeerReviewed 2019 ftuwarwick https://doi.org/10.1210/jc.2018-02743 2022-03-16T21:26:52Z Context Maternal gestational diabetes (GDM) and pre-pregnancy overweight/obesity (body mass index, BMI ≥25kg/m2) may adversely affect offspring cardio-metabolic health. Objective To assess associations of maternal GDM and pre-pregnancy overweight/obesity with adult offspring cardio-metabolic risk factors. Design Longitudinal cohort study (ESTER and AYLS). Setting Province of Uusimaa and Northern Finland. Participants At mean age 24.1 years (SD 1.3), we classified offspring to offspring of mothers with 1) GDM regardless of pre-pregnancy BMI (OGDM; n=193), 2) normoglycemic mothers with pre-pregnancy overweight/obesity (ONO, n=157) and 3) normoglycemic mothers with pre-pregnancy BMI<25kg/m2 (controls, n=556). Main Outcome Measures We assessed cardio-metabolic biomarkers from blood and measured resting blood pressure and heart rate. Results Compared with controls, OGDM and ONO had higher fasting glucose [1.6% (95% confidence interval 0.1, 3.1)]; [2.3% (0.5, 4.3), respectively]; and insulin [12.7% (4.4, 21.9)]; [8.7% (0.2, 17.8)]. These differences attenuated to non-significance when adjusted for confounders and/or current offspring characteristics including BMI or body fat percentage. OGDM showed lower sex hormone binding globulin [SHBG; men: -12.4% (-20.2, -3.9), women: -33.2% (-46.3, -16.8)], high-density lipoprotein [-6.6% (-10.9, -2.2)] and apolipoprotein A1 [-4.5% (-7.5, -1.4), these differences survived the aforementioned adjustments. Heart rate and other biomarkers were similar between groups. Conclusions Adult offspring of mothers with GDM have increased markers of insulin resistance and a more atherogenic lipid profile; these are only partly explained by confounders or current offspring adiposity. Maternal pre-pregnancy overweight/obesity is associated with impaired offspring glucose regulation, which is explained by confounders and/or current adiposity. Article in Journal/Newspaper Northern Finland The University of Warwick: WRAP - Warwick Research Archive Portal Uusimaa ENVELOPE(24.071,24.071,66.248,66.248) The Journal of Clinical Endocrinology & Metabolism 104 7 2785 2795 |
institution |
Open Polar |
collection |
The University of Warwick: WRAP - Warwick Research Archive Portal |
op_collection_id |
ftuwarwick |
language |
unknown |
topic |
RG Gynecology and obstetrics |
spellingShingle |
RG Gynecology and obstetrics Kaseva, Nina Vääräsmäki, Marja Sundvall, Jouko Matinolli, Hanna-Maria Sipola, Marika Tikanmäki, Marjaana Heinonen, Kati Lano, Aulikki Wehkalampi, Karoliina Wolke, Dieter Ruokonen, Aimo Andersson, Sture Järvelin, Marjo-Riitta Räikkönen, Katri Eriksson, Johan G. Kajantie, Eero Gestational diabetes, but not pre-pregnancy overweight predicts cardio-metabolic markers in offspring twenty years later |
topic_facet |
RG Gynecology and obstetrics |
description |
Context Maternal gestational diabetes (GDM) and pre-pregnancy overweight/obesity (body mass index, BMI ≥25kg/m2) may adversely affect offspring cardio-metabolic health. Objective To assess associations of maternal GDM and pre-pregnancy overweight/obesity with adult offspring cardio-metabolic risk factors. Design Longitudinal cohort study (ESTER and AYLS). Setting Province of Uusimaa and Northern Finland. Participants At mean age 24.1 years (SD 1.3), we classified offspring to offspring of mothers with 1) GDM regardless of pre-pregnancy BMI (OGDM; n=193), 2) normoglycemic mothers with pre-pregnancy overweight/obesity (ONO, n=157) and 3) normoglycemic mothers with pre-pregnancy BMI<25kg/m2 (controls, n=556). Main Outcome Measures We assessed cardio-metabolic biomarkers from blood and measured resting blood pressure and heart rate. Results Compared with controls, OGDM and ONO had higher fasting glucose [1.6% (95% confidence interval 0.1, 3.1)]; [2.3% (0.5, 4.3), respectively]; and insulin [12.7% (4.4, 21.9)]; [8.7% (0.2, 17.8)]. These differences attenuated to non-significance when adjusted for confounders and/or current offspring characteristics including BMI or body fat percentage. OGDM showed lower sex hormone binding globulin [SHBG; men: -12.4% (-20.2, -3.9), women: -33.2% (-46.3, -16.8)], high-density lipoprotein [-6.6% (-10.9, -2.2)] and apolipoprotein A1 [-4.5% (-7.5, -1.4), these differences survived the aforementioned adjustments. Heart rate and other biomarkers were similar between groups. Conclusions Adult offspring of mothers with GDM have increased markers of insulin resistance and a more atherogenic lipid profile; these are only partly explained by confounders or current offspring adiposity. Maternal pre-pregnancy overweight/obesity is associated with impaired offspring glucose regulation, which is explained by confounders and/or current adiposity. |
format |
Article in Journal/Newspaper |
author |
Kaseva, Nina Vääräsmäki, Marja Sundvall, Jouko Matinolli, Hanna-Maria Sipola, Marika Tikanmäki, Marjaana Heinonen, Kati Lano, Aulikki Wehkalampi, Karoliina Wolke, Dieter Ruokonen, Aimo Andersson, Sture Järvelin, Marjo-Riitta Räikkönen, Katri Eriksson, Johan G. Kajantie, Eero |
author_facet |
Kaseva, Nina Vääräsmäki, Marja Sundvall, Jouko Matinolli, Hanna-Maria Sipola, Marika Tikanmäki, Marjaana Heinonen, Kati Lano, Aulikki Wehkalampi, Karoliina Wolke, Dieter Ruokonen, Aimo Andersson, Sture Järvelin, Marjo-Riitta Räikkönen, Katri Eriksson, Johan G. Kajantie, Eero |
author_sort |
Kaseva, Nina |
title |
Gestational diabetes, but not pre-pregnancy overweight predicts cardio-metabolic markers in offspring twenty years later |
title_short |
Gestational diabetes, but not pre-pregnancy overweight predicts cardio-metabolic markers in offspring twenty years later |
title_full |
Gestational diabetes, but not pre-pregnancy overweight predicts cardio-metabolic markers in offspring twenty years later |
title_fullStr |
Gestational diabetes, but not pre-pregnancy overweight predicts cardio-metabolic markers in offspring twenty years later |
title_full_unstemmed |
Gestational diabetes, but not pre-pregnancy overweight predicts cardio-metabolic markers in offspring twenty years later |
title_sort |
gestational diabetes, but not pre-pregnancy overweight predicts cardio-metabolic markers in offspring twenty years later |
publisher |
The Endocrine Society |
publishDate |
2019 |
url |
http://wrap.warwick.ac.uk/114965/ http://wrap.warwick.ac.uk/114965/1/WRAP-Gestational-diabetes-pre-pregnancy-overweight-predicts-cardio-metabolic-Wolke-2019.pdf http://wrap.warwick.ac.uk/114965/2/WRAP-supplementary_tables_1-4.pdf http://wrap.warwick.ac.uk/114965/3/WRAP-figure_1_flow_chart_of_the_study_population.pptx http://wrap.warwick.ac.uk/114965/4/WRAP-tables_1-3.pdf https://doi.org/10.1210/jc.2018-02743 |
long_lat |
ENVELOPE(24.071,24.071,66.248,66.248) |
geographic |
Uusimaa |
geographic_facet |
Uusimaa |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
http://wrap.warwick.ac.uk/114965/1/WRAP-Gestational-diabetes-pre-pregnancy-overweight-predicts-cardio-metabolic-Wolke-2019.pdf http://wrap.warwick.ac.uk/114965/2/WRAP-supplementary_tables_1-4.pdf http://wrap.warwick.ac.uk/114965/3/WRAP-figure_1_flow_chart_of_the_study_population.pptx http://wrap.warwick.ac.uk/114965/4/WRAP-tables_1-3.pdf Kaseva, Nina, Vääräsmäki, Marja, Sundvall, Jouko, Matinolli, Hanna-Maria, Sipola, Marika, Tikanmäki, Marjaana, Heinonen, Kati, Lano, Aulikki, Wehkalampi, Karoliina, Wolke, Dieter, Ruokonen, Aimo, Andersson, Sture, Järvelin, Marjo-Riitta, Räikkönen, Katri, Eriksson, Johan G. and Kajantie, Eero (2019) Gestational diabetes, but not pre-pregnancy overweight predicts cardio-metabolic markers in offspring twenty years later. Journal of Clinical Endocrinology & Metabolism, 104 (7). pp. 2785-2795. doi:10.1210/jc.2018-02743 <http://dx.doi.org/10.1210/jc.2018-02743> |
op_doi |
https://doi.org/10.1210/jc.2018-02743 |
container_title |
The Journal of Clinical Endocrinology & Metabolism |
container_volume |
104 |
container_issue |
7 |
container_start_page |
2785 |
op_container_end_page |
2795 |
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1766144627074662400 |