Characterization of the Francisella pathogenicity Island-encoded type VI secretion system and the development of a vaccine candidate

• Main Author: Duplantis, Barry Neil
• Other Authors: Nano, Francis E.
• Format: Thesis
• Language: English
• Published: 2011
• Subjects: Francisella; Temperature sensitive; Type VI secretion; Psychrophile; Vaccine; Arctic; Igla
• Online Access: http://hdl.handle.net/1828/3737

F. tularensis is a Gram-negative bacterial pathogen and it is the causative agent of tularemia. It has the ability to replicate to high numbers within a variety of host cells, including macrophages. Little is known of its virulence mechanisms; however, all species of Francisella contain a cluster of...