The effect of whole-body cooling on renal function in post-cardiac arrest patients
Background: To evaluate the incidence of Acute Kidney Injury (AKI) during therapeutic hypothermia (TH) and rewarming in comatose patients resuscitated from Cardiac Arrest (CA).Methods: We have performed a pilot study of consecutive comatose patients resuscitated from CA and admitted to our Intensive...
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Online Access: | https://hdl.handle.net/11572/364365 https://doi.org/10.1186/s12882-017-0780-6 https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-017-0780-6 |
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ftutrentoiris:oai:iris.unitn.it:11572/364365 2024-02-11T10:01:35+01:00 The effect of whole-body cooling on renal function in post-cardiac arrest patients De Rosa, Silvia De Cal, Massimo Joannidis, Michael Villa, Gianluca Pacheco, Jose Luis Salas Virzì, Grazia Maria Samoni, Sara D'ippoliti, Fiorella Marcante, Stefano Visconti, Federico Lampariello, Antonella Zannato, Marina Marafon, Silvio Bonato, Raffaele Ronco, Claudio De Rosa, Silvia De Cal, Massimo Joannidis, Michael Villa, Gianluca Pacheco, Jose Luis Sala Virzì, Grazia Maria Samoni, Sara D'Ippoliti, Fiorella Marcante, Stefano Visconti, Federico Lampariello, Antonella Zannato, Marina Marafon, Silvio Bonato, Raffaele Ronco, Claudio 2017 https://hdl.handle.net/11572/364365 https://doi.org/10.1186/s12882-017-0780-6 https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-017-0780-6 eng eng info:eu-repo/semantics/altIdentifier/pmid/29284424 info:eu-repo/semantics/altIdentifier/wos/WOS:000418927200001 volume:18 issue:1 firstpage:37601 lastpage:37610 numberofpages:10 journal:BMC NEPHROLOGY https://hdl.handle.net/11572/364365 doi:10.1186/s12882-017-0780-6 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85039551887 https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-017-0780-6 info:eu-repo/semantics/openAccess Acute kidney injury Cardiac arrest Hypothermia Ischemia reperfusion injury Rewarming Injury info:eu-repo/semantics/article 2017 ftutrentoiris https://doi.org/10.1186/s12882-017-0780-6 2024-01-23T23:06:17Z Background: To evaluate the incidence of Acute Kidney Injury (AKI) during therapeutic hypothermia (TH) and rewarming in comatose patients resuscitated from Cardiac Arrest (CA).Methods: We have performed a pilot study of consecutive comatose patients resuscitated from CA and admitted to our Intensive Care Unit (ICU) from January 2013 to March 2015. The surface cooling devices used were: 1) Arctic Sun (R) 5000; 2) Blanketrol (R) III. Data obtained at baseline and during TH included: temperature trend and rate, serum creatinine, interleukin 1-beta, interleukin 6 (IL-6), urinary Interleukin-18 (uIL-18), diuretic use, urine output, fluid balance (FB). AKI was defined according to Kidney Diseases Improving Global Outcomes (KDIGO) criteria.Results: Thirty-six patients were treated with TH out of 46 ICU admissions (78%). According to KDIGO classification, 21 (58%) had no evidence of AKI while 15 (41.7%) presented AKI during TH. In particular, the incidence of AKI was 2.8% at 24 h, 33.33% at 48 h and 30.6% at 72 h from the onset of cooling. Slower rewarming (above 600 min) was associated with with a non-significant lower incidence of AKI and with a non-significant lower levels of IL-6 and IL-18u. Only two patients required renal replacement therapy during TH (7.6%). Median cumulative FB was 2441 [437-4043] ml for all patients; 3140 [1421-4347] and 1332 [-131-3772] specifically for AKI and not-AKI patients.Conclusions: The hypothermia treatment, if not well performed, could be a double-edged sword for kidneys: whereas hypothermia may confer protection by reducing metabolism and oxygen consumption, rapid rewarming could nullify benefits leading to a worsening of kidney function and AKI. Additional clinical studies are needed to determine the optimal rewarming rate and strategy. Article in Journal/Newspaper Arctic Università degli Studi di Trento: CINECA IRIS Arctic BMC Nephrology 18 1 |
institution |
Open Polar |
collection |
Università degli Studi di Trento: CINECA IRIS |
op_collection_id |
ftutrentoiris |
language |
English |
topic |
Acute kidney injury Cardiac arrest Hypothermia Ischemia reperfusion injury Rewarming Injury |
spellingShingle |
Acute kidney injury Cardiac arrest Hypothermia Ischemia reperfusion injury Rewarming Injury De Rosa, Silvia De Cal, Massimo Joannidis, Michael Villa, Gianluca Pacheco, Jose Luis Salas Virzì, Grazia Maria Samoni, Sara D'ippoliti, Fiorella Marcante, Stefano Visconti, Federico Lampariello, Antonella Zannato, Marina Marafon, Silvio Bonato, Raffaele Ronco, Claudio The effect of whole-body cooling on renal function in post-cardiac arrest patients |
topic_facet |
Acute kidney injury Cardiac arrest Hypothermia Ischemia reperfusion injury Rewarming Injury |
description |
Background: To evaluate the incidence of Acute Kidney Injury (AKI) during therapeutic hypothermia (TH) and rewarming in comatose patients resuscitated from Cardiac Arrest (CA).Methods: We have performed a pilot study of consecutive comatose patients resuscitated from CA and admitted to our Intensive Care Unit (ICU) from January 2013 to March 2015. The surface cooling devices used were: 1) Arctic Sun (R) 5000; 2) Blanketrol (R) III. Data obtained at baseline and during TH included: temperature trend and rate, serum creatinine, interleukin 1-beta, interleukin 6 (IL-6), urinary Interleukin-18 (uIL-18), diuretic use, urine output, fluid balance (FB). AKI was defined according to Kidney Diseases Improving Global Outcomes (KDIGO) criteria.Results: Thirty-six patients were treated with TH out of 46 ICU admissions (78%). According to KDIGO classification, 21 (58%) had no evidence of AKI while 15 (41.7%) presented AKI during TH. In particular, the incidence of AKI was 2.8% at 24 h, 33.33% at 48 h and 30.6% at 72 h from the onset of cooling. Slower rewarming (above 600 min) was associated with with a non-significant lower incidence of AKI and with a non-significant lower levels of IL-6 and IL-18u. Only two patients required renal replacement therapy during TH (7.6%). Median cumulative FB was 2441 [437-4043] ml for all patients; 3140 [1421-4347] and 1332 [-131-3772] specifically for AKI and not-AKI patients.Conclusions: The hypothermia treatment, if not well performed, could be a double-edged sword for kidneys: whereas hypothermia may confer protection by reducing metabolism and oxygen consumption, rapid rewarming could nullify benefits leading to a worsening of kidney function and AKI. Additional clinical studies are needed to determine the optimal rewarming rate and strategy. |
author2 |
De Rosa, Silvia De Cal, Massimo Joannidis, Michael Villa, Gianluca Pacheco, Jose Luis Sala Virzì, Grazia Maria Samoni, Sara D'Ippoliti, Fiorella Marcante, Stefano Visconti, Federico Lampariello, Antonella Zannato, Marina Marafon, Silvio Bonato, Raffaele Ronco, Claudio |
format |
Article in Journal/Newspaper |
author |
De Rosa, Silvia De Cal, Massimo Joannidis, Michael Villa, Gianluca Pacheco, Jose Luis Salas Virzì, Grazia Maria Samoni, Sara D'ippoliti, Fiorella Marcante, Stefano Visconti, Federico Lampariello, Antonella Zannato, Marina Marafon, Silvio Bonato, Raffaele Ronco, Claudio |
author_facet |
De Rosa, Silvia De Cal, Massimo Joannidis, Michael Villa, Gianluca Pacheco, Jose Luis Salas Virzì, Grazia Maria Samoni, Sara D'ippoliti, Fiorella Marcante, Stefano Visconti, Federico Lampariello, Antonella Zannato, Marina Marafon, Silvio Bonato, Raffaele Ronco, Claudio |
author_sort |
De Rosa, Silvia |
title |
The effect of whole-body cooling on renal function in post-cardiac arrest patients |
title_short |
The effect of whole-body cooling on renal function in post-cardiac arrest patients |
title_full |
The effect of whole-body cooling on renal function in post-cardiac arrest patients |
title_fullStr |
The effect of whole-body cooling on renal function in post-cardiac arrest patients |
title_full_unstemmed |
The effect of whole-body cooling on renal function in post-cardiac arrest patients |
title_sort |
effect of whole-body cooling on renal function in post-cardiac arrest patients |
publishDate |
2017 |
url |
https://hdl.handle.net/11572/364365 https://doi.org/10.1186/s12882-017-0780-6 https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-017-0780-6 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/29284424 info:eu-repo/semantics/altIdentifier/wos/WOS:000418927200001 volume:18 issue:1 firstpage:37601 lastpage:37610 numberofpages:10 journal:BMC NEPHROLOGY https://hdl.handle.net/11572/364365 doi:10.1186/s12882-017-0780-6 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85039551887 https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-017-0780-6 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1186/s12882-017-0780-6 |
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BMC Nephrology |
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18 |
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1 |
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