Activity of Scottish plant, lichen and fungal endophyte extracts against Mycobacterium aurum and Mycobacterium tuberculosis
With tuberculosis the leading bacterial killer worldwide and other mycobacterial diseases on the increase, the search for new antimycobacterial agents is timely. In this study, extracts from plants, lichens and fungal endophytes of Scottish provenance were screened for activity against Mycobacterium...
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ftustrathclyde:oai:strathprints.strath.ac.uk:25960 2024-04-28T08:17:53+00:00 Activity of Scottish plant, lichen and fungal endophyte extracts against Mycobacterium aurum and Mycobacterium tuberculosis Gordien, Andréa Y. Gray, Alexander I. Ingleby, Kevin Franzblau, Scott G. Seidel, Veronique 2010-05-01 https://strathprints.strath.ac.uk/25960/ https://doi.org/10.1002/ptr.2988 unknown Gordien, Andréa Y. <https://strathprints.strath.ac.uk/view/author/512285.html> and Gray, Alexander I. <https://strathprints.strath.ac.uk/view/author/22145.html> and Ingleby, Kevin and Franzblau, Scott G. and Seidel, Veronique <https://strathprints.strath.ac.uk/view/author/79668.html> (2010 <https://strathprints.strath.ac.uk/view/year/2010.html>) Activity of Scottish plant, lichen and fungal endophyte extracts against Mycobacterium aurum and Mycobacterium tuberculosis. Phytotherapy Research <https://strathprints.strath.ac.uk/view/publications/Phytotherapy_Research.html>, 24 (5). pp. 692-698. ISSN 0951-418X Plant culture Pharmacy and materia medica Article PeerReviewed 2010 ftustrathclyde https://doi.org/10.1002/ptr.2988 2024-04-10T00:41:24Z With tuberculosis the leading bacterial killer worldwide and other mycobacterial diseases on the increase, the search for new antimycobacterial agents is timely. In this study, extracts from plants, lichens and fungal endophytes of Scottish provenance were screened for activity against Mycobacterium aurum and M. tuberculosis H37Rv. The best activity against M. aurum was observed for extracts of Juniperus communis roots and Cladonia arbuscula (MIC = 4 µg/mL), and a fungal endophyte isolated from Vaccinium myrtillus (MIC = 8 µg/mL). The best activity against M. tuberculosis was observed for extracts of C. arbuscula, Empetrum nigrum, J. communis roots, Calluna vulgaris aerial parts, Myrica gale roots and stems (93 to 99% inhibition at 100 µg/mL). Potent antitubercular activity (90 to 96% inhibition at 100 µg/mL) was also observed for the ethanol extracts of Xerocomus badius, Chalciporus piperatus, Suillus luteus and of endophytes isolated from C. vulgaris, E. nigrum, Vaccinium vitis-idaea and V. myrtillus. The results obtained this study provide, in part, some scientific basis for the traditional use of some of the selected plants in the treatment of tuberculosis. They also indicate that fungal endophytes recovered from Scottish plants are a source of antimycobacterial agents worthy of further investigation Article in Journal/Newspaper Empetrum nigrum University of Strathclyde Glasgow: Strathprints Phytotherapy Research 24 5 692 698 |
institution |
Open Polar |
collection |
University of Strathclyde Glasgow: Strathprints |
op_collection_id |
ftustrathclyde |
language |
unknown |
topic |
Plant culture Pharmacy and materia medica |
spellingShingle |
Plant culture Pharmacy and materia medica Gordien, Andréa Y. Gray, Alexander I. Ingleby, Kevin Franzblau, Scott G. Seidel, Veronique Activity of Scottish plant, lichen and fungal endophyte extracts against Mycobacterium aurum and Mycobacterium tuberculosis |
topic_facet |
Plant culture Pharmacy and materia medica |
description |
With tuberculosis the leading bacterial killer worldwide and other mycobacterial diseases on the increase, the search for new antimycobacterial agents is timely. In this study, extracts from plants, lichens and fungal endophytes of Scottish provenance were screened for activity against Mycobacterium aurum and M. tuberculosis H37Rv. The best activity against M. aurum was observed for extracts of Juniperus communis roots and Cladonia arbuscula (MIC = 4 µg/mL), and a fungal endophyte isolated from Vaccinium myrtillus (MIC = 8 µg/mL). The best activity against M. tuberculosis was observed for extracts of C. arbuscula, Empetrum nigrum, J. communis roots, Calluna vulgaris aerial parts, Myrica gale roots and stems (93 to 99% inhibition at 100 µg/mL). Potent antitubercular activity (90 to 96% inhibition at 100 µg/mL) was also observed for the ethanol extracts of Xerocomus badius, Chalciporus piperatus, Suillus luteus and of endophytes isolated from C. vulgaris, E. nigrum, Vaccinium vitis-idaea and V. myrtillus. The results obtained this study provide, in part, some scientific basis for the traditional use of some of the selected plants in the treatment of tuberculosis. They also indicate that fungal endophytes recovered from Scottish plants are a source of antimycobacterial agents worthy of further investigation |
format |
Article in Journal/Newspaper |
author |
Gordien, Andréa Y. Gray, Alexander I. Ingleby, Kevin Franzblau, Scott G. Seidel, Veronique |
author_facet |
Gordien, Andréa Y. Gray, Alexander I. Ingleby, Kevin Franzblau, Scott G. Seidel, Veronique |
author_sort |
Gordien, Andréa Y. |
title |
Activity of Scottish plant, lichen and fungal endophyte extracts against Mycobacterium aurum and Mycobacterium tuberculosis |
title_short |
Activity of Scottish plant, lichen and fungal endophyte extracts against Mycobacterium aurum and Mycobacterium tuberculosis |
title_full |
Activity of Scottish plant, lichen and fungal endophyte extracts against Mycobacterium aurum and Mycobacterium tuberculosis |
title_fullStr |
Activity of Scottish plant, lichen and fungal endophyte extracts against Mycobacterium aurum and Mycobacterium tuberculosis |
title_full_unstemmed |
Activity of Scottish plant, lichen and fungal endophyte extracts against Mycobacterium aurum and Mycobacterium tuberculosis |
title_sort |
activity of scottish plant, lichen and fungal endophyte extracts against mycobacterium aurum and mycobacterium tuberculosis |
publishDate |
2010 |
url |
https://strathprints.strath.ac.uk/25960/ https://doi.org/10.1002/ptr.2988 |
genre |
Empetrum nigrum |
genre_facet |
Empetrum nigrum |
op_relation |
Gordien, Andréa Y. <https://strathprints.strath.ac.uk/view/author/512285.html> and Gray, Alexander I. <https://strathprints.strath.ac.uk/view/author/22145.html> and Ingleby, Kevin and Franzblau, Scott G. and Seidel, Veronique <https://strathprints.strath.ac.uk/view/author/79668.html> (2010 <https://strathprints.strath.ac.uk/view/year/2010.html>) Activity of Scottish plant, lichen and fungal endophyte extracts against Mycobacterium aurum and Mycobacterium tuberculosis. Phytotherapy Research <https://strathprints.strath.ac.uk/view/publications/Phytotherapy_Research.html>, 24 (5). pp. 692-698. ISSN 0951-418X |
op_doi |
https://doi.org/10.1002/ptr.2988 |
container_title |
Phytotherapy Research |
container_volume |
24 |
container_issue |
5 |
container_start_page |
692 |
op_container_end_page |
698 |
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1797582180768022528 |