Dha Derivatives of Fish Oil as Dietary Supplements: a Nutrition-Based Drug Discovery Approach for Therapies to Prevent Metabolic Cardiotoxicity
Introduction: During the early 1970s, Danish physicians Jorn Dyerberg and colleagues observed that Greenland Eskimos consuming fatty fishes exhibited low incidences of heart disease. Fish oil is now one of the most commonly consumed dietary supplements. In 2004, concentrated fish oil was approved as...
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Digital Commons @ University of South Florida
2012
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ftusouthflorida:oai:digitalcommons.usf.edu:intmed_facpub-1063 2023-07-30T04:03:20+02:00 Dha Derivatives of Fish Oil as Dietary Supplements: a Nutrition-Based Drug Discovery Approach for Therapies to Prevent Metabolic Cardiotoxicity Ma, Yonggang Lindsey, Merry L. Halade, Ganesh V. 2012-08-01T07:00:00Z application/pdf https://digitalcommons.usf.edu/intmed_facpub/64 https://doi.org/10.1517/17460441.2012.694862 https://digitalcommons.usf.edu/context/intmed_facpub/article/1063/viewcontent/nihms563578.pdf unknown Digital Commons @ University of South Florida https://digitalcommons.usf.edu/intmed_facpub/64 doi:10.1517/17460441.2012.694862 https://digitalcommons.usf.edu/context/intmed_facpub/article/1063/viewcontent/nihms563578.pdf default Internal Medicine Faculty Publications Cardiovascular disease Dietary supplement Docosahexaenoic acid Eicosapentaenoic acid Fish oil Metabolic syndrome Obesity review 2012 ftusouthflorida https://doi.org/10.1517/17460441.2012.694862 2023-07-13T20:49:24Z Introduction: During the early 1970s, Danish physicians Jorn Dyerberg and colleagues observed that Greenland Eskimos consuming fatty fishes exhibited low incidences of heart disease. Fish oil is now one of the most commonly consumed dietary supplements. In 2004, concentrated fish oil was approved as a drug by the FDA for the treatment of hyperlipidemia. Fish oil contains two major omega-3 fatty acids: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). With advancements in lipid concentration and purification techniques, EPA- or DHA-enriched products are now commercially available, and the availability of these components in isolation allows their individual effects to be examined. Newly synthesized derivatives and endogenously discovered metabolites of DHA exhibit therapeutic utility for obesity, metabolic syndrome and cardiovascular disease. Areas covered: This review summarizes our current knowledge on the distinct effects of EPA and DHA to prevent metabolic syndrome and reduce cardiotoxicity risk. Since EPA is an integral component of fish oil, we will briefly review EPA effects, but our main theme will be to summarize effects of the DHA derivatives that are available today. We focus on using nutrition-based drug discovery to explore the potential of DHA derivatives for the treatment of obesity, metabolic syndrome and cardiovascular diseases. Expert opinion: The safety and efficacy evaluation of DHA derivatives will provide novel biomolecules for the drug discovery arsenal. Novel nutritional-based drug discoveries of DHA derivatives or metabolites may provide realistic and alternative strategies for the treatment of metabolic and cardiovascular disease. Review eskimo* Greenland University of South Florida St. Petersburg: Digital USFSP Greenland Expert Opinion on Drug Discovery 7 8 711 721 |
institution |
Open Polar |
collection |
University of South Florida St. Petersburg: Digital USFSP |
op_collection_id |
ftusouthflorida |
language |
unknown |
topic |
Cardiovascular disease Dietary supplement Docosahexaenoic acid Eicosapentaenoic acid Fish oil Metabolic syndrome Obesity |
spellingShingle |
Cardiovascular disease Dietary supplement Docosahexaenoic acid Eicosapentaenoic acid Fish oil Metabolic syndrome Obesity Ma, Yonggang Lindsey, Merry L. Halade, Ganesh V. Dha Derivatives of Fish Oil as Dietary Supplements: a Nutrition-Based Drug Discovery Approach for Therapies to Prevent Metabolic Cardiotoxicity |
topic_facet |
Cardiovascular disease Dietary supplement Docosahexaenoic acid Eicosapentaenoic acid Fish oil Metabolic syndrome Obesity |
description |
Introduction: During the early 1970s, Danish physicians Jorn Dyerberg and colleagues observed that Greenland Eskimos consuming fatty fishes exhibited low incidences of heart disease. Fish oil is now one of the most commonly consumed dietary supplements. In 2004, concentrated fish oil was approved as a drug by the FDA for the treatment of hyperlipidemia. Fish oil contains two major omega-3 fatty acids: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). With advancements in lipid concentration and purification techniques, EPA- or DHA-enriched products are now commercially available, and the availability of these components in isolation allows their individual effects to be examined. Newly synthesized derivatives and endogenously discovered metabolites of DHA exhibit therapeutic utility for obesity, metabolic syndrome and cardiovascular disease. Areas covered: This review summarizes our current knowledge on the distinct effects of EPA and DHA to prevent metabolic syndrome and reduce cardiotoxicity risk. Since EPA is an integral component of fish oil, we will briefly review EPA effects, but our main theme will be to summarize effects of the DHA derivatives that are available today. We focus on using nutrition-based drug discovery to explore the potential of DHA derivatives for the treatment of obesity, metabolic syndrome and cardiovascular diseases. Expert opinion: The safety and efficacy evaluation of DHA derivatives will provide novel biomolecules for the drug discovery arsenal. Novel nutritional-based drug discoveries of DHA derivatives or metabolites may provide realistic and alternative strategies for the treatment of metabolic and cardiovascular disease. |
format |
Review |
author |
Ma, Yonggang Lindsey, Merry L. Halade, Ganesh V. |
author_facet |
Ma, Yonggang Lindsey, Merry L. Halade, Ganesh V. |
author_sort |
Ma, Yonggang |
title |
Dha Derivatives of Fish Oil as Dietary Supplements: a Nutrition-Based Drug Discovery Approach for Therapies to Prevent Metabolic Cardiotoxicity |
title_short |
Dha Derivatives of Fish Oil as Dietary Supplements: a Nutrition-Based Drug Discovery Approach for Therapies to Prevent Metabolic Cardiotoxicity |
title_full |
Dha Derivatives of Fish Oil as Dietary Supplements: a Nutrition-Based Drug Discovery Approach for Therapies to Prevent Metabolic Cardiotoxicity |
title_fullStr |
Dha Derivatives of Fish Oil as Dietary Supplements: a Nutrition-Based Drug Discovery Approach for Therapies to Prevent Metabolic Cardiotoxicity |
title_full_unstemmed |
Dha Derivatives of Fish Oil as Dietary Supplements: a Nutrition-Based Drug Discovery Approach for Therapies to Prevent Metabolic Cardiotoxicity |
title_sort |
dha derivatives of fish oil as dietary supplements: a nutrition-based drug discovery approach for therapies to prevent metabolic cardiotoxicity |
publisher |
Digital Commons @ University of South Florida |
publishDate |
2012 |
url |
https://digitalcommons.usf.edu/intmed_facpub/64 https://doi.org/10.1517/17460441.2012.694862 https://digitalcommons.usf.edu/context/intmed_facpub/article/1063/viewcontent/nihms563578.pdf |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
eskimo* Greenland |
genre_facet |
eskimo* Greenland |
op_source |
Internal Medicine Faculty Publications |
op_relation |
https://digitalcommons.usf.edu/intmed_facpub/64 doi:10.1517/17460441.2012.694862 https://digitalcommons.usf.edu/context/intmed_facpub/article/1063/viewcontent/nihms563578.pdf |
op_rights |
default |
op_doi |
https://doi.org/10.1517/17460441.2012.694862 |
container_title |
Expert Opinion on Drug Discovery |
container_volume |
7 |
container_issue |
8 |
container_start_page |
711 |
op_container_end_page |
721 |
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1772814311031308288 |