The Chemical Ecology and Drug Discovery Potential of the Antarctic Red Alga Plocamium cartilagineum and the Antarctic Sponge Dendrilla membranosa
Chemical ecology is the study of chemical interactions between organisms and their environment mediated by small molecules involved in nonessential physiological functions, known as secondary metabolites. These compounds can be crucial to survival of the organism, and have also provided the field of...
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ftusouthflorida:oai:digitalcommons.usf.edu:etd-9881 2023-07-30T03:57:49+02:00 The Chemical Ecology and Drug Discovery Potential of the Antarctic Red Alga Plocamium cartilagineum and the Antarctic Sponge Dendrilla membranosa Shilling, Andrew Jason 2019-11-12T08:00:00Z application/pdf https://digitalcommons.usf.edu/etd/8684 https://digitalcommons.usf.edu/context/etd/article/9881/viewcontent/Shilling_usf_0206D_15759.pdf unknown Digital Commons @ University of South Florida https://digitalcommons.usf.edu/etd/8684 https://digitalcommons.usf.edu/context/etd/article/9881/viewcontent/Shilling_usf_0206D_15759.pdf default USF Tampa Graduate Theses and Dissertations anverenes dendrillins membranoids metabolomics natural products Chemistry dissertation 2019 ftusouthflorida 2023-07-13T20:50:19Z Chemical ecology is the study of chemical interactions between organisms and their environment mediated by small molecules involved in nonessential physiological functions, known as secondary metabolites. These compounds can be crucial to survival of the organism, and have also provided the field of medicine with some of history’s most influential drugs, referred to in that context as natural products. Antarctica is a dynamic and understudied environment, which affords the opportunity to examine the chemical ecology of unique organisms while simultaneously evaluating their novel chemistry for potential therapeutic properties as natural products. Plocamium cartilagineum is a red macroalgal species found in the shallow waters of Antarctica known to produce many cytotoxic polyhalogenated monoterpenes thought to serve as feeding deterrents to sympatric algal consumers. Individuals around Palmer Station on Anvers Island can be classified into two distinct genotypes, both shown to produce varying combinations of these chemical defenses linked with site specificity, suggesting each alga is able to tailor its defenses to better suit its unique set of environmental conditions. Metabolomic data linked with genomic analysis from newer and larger field collections during the 2016-2018 field seasons show an even greater diversity of chemical phenotypes than previously found, and that both genotype and depth seem to play a role determining the constituency of the chemical feeding deterrents produced. In an attempt to further evaluate this diversity, the major components of several of the most common chemogroups at our collection sites were determined using GC/MS and NMR guided fractionation. In the process, a small library of anverene-like (2.22) polyhalogenated monoterpenes was generated, containing several known compounds and four previously undescribed natural products, referred to as anverenes B-E (2.29-2.31, 2.34). This collection of molecules was screened for cytotoxicity towards human cervical cancer cells, and ... Doctoral or Postdoctoral Thesis Antarc* Antarctic Antarctica Anvers Island University of South Florida St. Petersburg: Digital USFSP Antarctic Anvers ENVELOPE(-63.500,-63.500,-64.600,-64.600) Anvers Island ENVELOPE(-63.500,-63.500,-64.600,-64.600) Palmer Station ENVELOPE(-64.050,-64.050,-64.770,-64.770) Palmer-Station ENVELOPE(-64.050,-64.050,-64.770,-64.770) The Antarctic |
institution |
Open Polar |
collection |
University of South Florida St. Petersburg: Digital USFSP |
op_collection_id |
ftusouthflorida |
language |
unknown |
topic |
anverenes dendrillins membranoids metabolomics natural products Chemistry |
spellingShingle |
anverenes dendrillins membranoids metabolomics natural products Chemistry Shilling, Andrew Jason The Chemical Ecology and Drug Discovery Potential of the Antarctic Red Alga Plocamium cartilagineum and the Antarctic Sponge Dendrilla membranosa |
topic_facet |
anverenes dendrillins membranoids metabolomics natural products Chemistry |
description |
Chemical ecology is the study of chemical interactions between organisms and their environment mediated by small molecules involved in nonessential physiological functions, known as secondary metabolites. These compounds can be crucial to survival of the organism, and have also provided the field of medicine with some of history’s most influential drugs, referred to in that context as natural products. Antarctica is a dynamic and understudied environment, which affords the opportunity to examine the chemical ecology of unique organisms while simultaneously evaluating their novel chemistry for potential therapeutic properties as natural products. Plocamium cartilagineum is a red macroalgal species found in the shallow waters of Antarctica known to produce many cytotoxic polyhalogenated monoterpenes thought to serve as feeding deterrents to sympatric algal consumers. Individuals around Palmer Station on Anvers Island can be classified into two distinct genotypes, both shown to produce varying combinations of these chemical defenses linked with site specificity, suggesting each alga is able to tailor its defenses to better suit its unique set of environmental conditions. Metabolomic data linked with genomic analysis from newer and larger field collections during the 2016-2018 field seasons show an even greater diversity of chemical phenotypes than previously found, and that both genotype and depth seem to play a role determining the constituency of the chemical feeding deterrents produced. In an attempt to further evaluate this diversity, the major components of several of the most common chemogroups at our collection sites were determined using GC/MS and NMR guided fractionation. In the process, a small library of anverene-like (2.22) polyhalogenated monoterpenes was generated, containing several known compounds and four previously undescribed natural products, referred to as anverenes B-E (2.29-2.31, 2.34). This collection of molecules was screened for cytotoxicity towards human cervical cancer cells, and ... |
format |
Doctoral or Postdoctoral Thesis |
author |
Shilling, Andrew Jason |
author_facet |
Shilling, Andrew Jason |
author_sort |
Shilling, Andrew Jason |
title |
The Chemical Ecology and Drug Discovery Potential of the Antarctic Red Alga Plocamium cartilagineum and the Antarctic Sponge Dendrilla membranosa |
title_short |
The Chemical Ecology and Drug Discovery Potential of the Antarctic Red Alga Plocamium cartilagineum and the Antarctic Sponge Dendrilla membranosa |
title_full |
The Chemical Ecology and Drug Discovery Potential of the Antarctic Red Alga Plocamium cartilagineum and the Antarctic Sponge Dendrilla membranosa |
title_fullStr |
The Chemical Ecology and Drug Discovery Potential of the Antarctic Red Alga Plocamium cartilagineum and the Antarctic Sponge Dendrilla membranosa |
title_full_unstemmed |
The Chemical Ecology and Drug Discovery Potential of the Antarctic Red Alga Plocamium cartilagineum and the Antarctic Sponge Dendrilla membranosa |
title_sort |
chemical ecology and drug discovery potential of the antarctic red alga plocamium cartilagineum and the antarctic sponge dendrilla membranosa |
publisher |
Digital Commons @ University of South Florida |
publishDate |
2019 |
url |
https://digitalcommons.usf.edu/etd/8684 https://digitalcommons.usf.edu/context/etd/article/9881/viewcontent/Shilling_usf_0206D_15759.pdf |
long_lat |
ENVELOPE(-63.500,-63.500,-64.600,-64.600) ENVELOPE(-63.500,-63.500,-64.600,-64.600) ENVELOPE(-64.050,-64.050,-64.770,-64.770) ENVELOPE(-64.050,-64.050,-64.770,-64.770) |
geographic |
Antarctic Anvers Anvers Island Palmer Station Palmer-Station The Antarctic |
geographic_facet |
Antarctic Anvers Anvers Island Palmer Station Palmer-Station The Antarctic |
genre |
Antarc* Antarctic Antarctica Anvers Island |
genre_facet |
Antarc* Antarctic Antarctica Anvers Island |
op_source |
USF Tampa Graduate Theses and Dissertations |
op_relation |
https://digitalcommons.usf.edu/etd/8684 https://digitalcommons.usf.edu/context/etd/article/9881/viewcontent/Shilling_usf_0206D_15759.pdf |
op_rights |
default |
_version_ |
1772819599117516800 |