Роль полиморфизма rs7903146 гена tcf7l2 в развитии нарушений углеводного обмена у молодых пациентов с метаболическим синдромом

• Main Authors: Korneeva, E. V., Voevoda, M. I., Semaev, S. E., Maksimov, V. N., Корнеева, Е. В., Воевода, М. И., Семаев, С. Е., Максимов, В. Н.
• Format: Article in Journal/Newspaper
• Language: Russian
• Published: ООО «Уральский Центр Медицинской и Фармацевтической Информации» 2020
• Subjects: METABOLIC SYNDROME; DIABETES MELLITUS; RS7903146 POLYMORPHISM OF THE TCF7L2 GENE; HYPERGLYCEMIA; МЕТАБОЛИЧЕСКИЙ СИНДРОМ; САХАРНЫЙ; ДИАБЕТ; ПОЛИМОРФИЗМ RS7903146 ГЕНА TCF7L2; ГИПЕРГЛИКЕМИЯ; khanty
• Online Access: http://elib.usma.ru/handle/usma/18881

Objective: to study the role of rs7903146 polymorphism of the TCF7L2 gene in the development of carbohydrate metabolism disorders in young patients with metabolic syndrome living in northern conditions. Materials and methods: 835 young residents of the North were examined, 701 of them with MS and 134 healthy people. Non-indigenous inhabitants (n = 569) are represented by urban and rural population, the indigenous population of the North (khanty) - 266 people. An anthropometric, laboratory study (evaluation of carbohydrate metabolism) was carried out, molecular genetic research included the isolation of genomic DNA using a polymerase chain reaction with restriction fragment length polymorphism (PCR with RFLP). Results. Among all participants in the study, the mutant T allele was found in 21.9% (22.3% of non-indigenous inhabitants and 20.9% of Khanty). In the examined cohort of patients with MS, the mutant T allele rs7903146 of the TCF7L2 gene was more common in patients with IR (23.2%, OR 1.146, 95% CI 0.872-1.505, p = 0.026). Moreover, there were more carriers of this allele among the indigenous population with MS and hyperglycemia (26.8%, OS 1.676, 95% CI 0.412-1.286, p = 0.048) than among non-indigenous people (22.0%, OS 0.968, 95% CI 0.699-1.341, p = 0.023) and among Khanty with MS, but without hyperglycemia (17.9%, OR 1.011, 95% CI 1.016-2.764, p = 0.051). Conclusions: the presence of the rs7903146 variant of the TCF7L2 gene plays an important role in the development of diabetes in people with MS. Цель: изучить роль полиморфизма rs7903146 гена TCF7L2 в развитии нарушений углеводного обмена у молодых пациентов с метаболическим синдромом, проживающих в северных условиях. Материалы и методы: обследовано 835 молодых жителей Севера, из них 701 человек с МС и 134 здоровых людей. Некоренные жители (n=569) представлены городским и сельским населением, коренное малочисленное население севера (ханты) - 266 человек. Проведено антропометрическое, лабораторное исследование (оценка углеводного обмена), ...