Were cancer patients worse off than the general population during the COVID-19 pandemic? : A population-based study from Norway, Denmark and Iceland during the pre-vaccination era
Background In a population-based setting, we investigated the risks of testing positive for SARS-CoV-2 and developing severe COVID-19 outcomes among cancer patients compared with the general population.Methods In nationwide cohorts, we identified all individuals in Norway, Denmark and Iceland who te...
Published in: | The Lancet Regional Health - Europe |
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Main Authors: | , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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Uppsala universitet, Cancerimmunterapi
2023
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Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-520215 https://doi.org/10.1016/j.lanepe.2023.100680 |
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topic |
COVID-19 Coronavirus disease 2019 SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Cancer Hospitalisation Critical care outcomes Intensive care Mortality Nordic Denmark Norway Iceland Cancer and Oncology Cancer och onkologi Infectious Medicine Infektionsmedicin Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
spellingShingle |
COVID-19 Coronavirus disease 2019 SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Cancer Hospitalisation Critical care outcomes Intensive care Mortality Nordic Denmark Norway Iceland Cancer and Oncology Cancer och onkologi Infectious Medicine Infektionsmedicin Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Johansson, Anna L., V Skog, Anna Johannesen, Tom Borge Myklebust, Tor age Skovlund, Charlotte Wessel Morch, Lina Steinrud Friis, Soren Gamborg, Mads Kristiansen, Marnar Frioheim Pettersson, David Olafsdottir, Elinborg J. Birgisson, Helgi Palsson, Runolfur Eythorsson, Elias Irenaeus, Sandra Lambe, Mats Ursin, Giske Were cancer patients worse off than the general population during the COVID-19 pandemic? : A population-based study from Norway, Denmark and Iceland during the pre-vaccination era |
topic_facet |
COVID-19 Coronavirus disease 2019 SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Cancer Hospitalisation Critical care outcomes Intensive care Mortality Nordic Denmark Norway Iceland Cancer and Oncology Cancer och onkologi Infectious Medicine Infektionsmedicin Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
description |
Background In a population-based setting, we investigated the risks of testing positive for SARS-CoV-2 and developing severe COVID-19 outcomes among cancer patients compared with the general population.Methods In nationwide cohorts, we identified all individuals in Norway, Denmark and Iceland who tested positive for SARS-CoV-2 or had a severe COVID-19 outcome (hospitalisation, intensive care, and death) from March until December 2020, using data from national health registries. We estimated standardised incidence ratios (SIRs) with 95% confidence intervals (CIs) comparing cancer patients with the general population.Findings During the first wave of the pandemic, cancer patients in Norway and Denmark had higher risks of testing SARS-CoV-2 positive compared to the general population. Throughout 2020, recently treated cancer patients were more likely to test SARS-CoV-2 positive. In Iceland, cancer patients experienced no increased risk of testing positive. The risk of COVID-19-related hospitalisation was higher among cancer patients diagnosed within one year of hospitalisation (Norway: SIR = 2.43, 95% CI 1.89-3.09; Denmark: 2.23, 1.96-2.54) and within five years (Norway: 1.58, 1.35-1.83; Denmark: 1.54, 1.42-1.66). Risks were higher in recently treated cancer patients and in those diagnosed with haematologic malignancies, colorectal or lung cancer. Risks of COVID-19-related intensive care and death were higher among cancer patients. Interpretation Cancer patients were at increased risk of testing positive for SARS-CoV-2 during the first pandemic wave when testing availability was limited, while relative risks of severe COVID-19 outcomes remained increased in cancer patients throughout 2020. Recent cancer treatment and haematologic malignancy were the strongest risk factors. |
format |
Article in Journal/Newspaper |
author |
Johansson, Anna L., V Skog, Anna Johannesen, Tom Borge Myklebust, Tor age Skovlund, Charlotte Wessel Morch, Lina Steinrud Friis, Soren Gamborg, Mads Kristiansen, Marnar Frioheim Pettersson, David Olafsdottir, Elinborg J. Birgisson, Helgi Palsson, Runolfur Eythorsson, Elias Irenaeus, Sandra Lambe, Mats Ursin, Giske |
author_facet |
Johansson, Anna L., V Skog, Anna Johannesen, Tom Borge Myklebust, Tor age Skovlund, Charlotte Wessel Morch, Lina Steinrud Friis, Soren Gamborg, Mads Kristiansen, Marnar Frioheim Pettersson, David Olafsdottir, Elinborg J. Birgisson, Helgi Palsson, Runolfur Eythorsson, Elias Irenaeus, Sandra Lambe, Mats Ursin, Giske |
author_sort |
Johansson, Anna L., V |
title |
Were cancer patients worse off than the general population during the COVID-19 pandemic? : A population-based study from Norway, Denmark and Iceland during the pre-vaccination era |
title_short |
Were cancer patients worse off than the general population during the COVID-19 pandemic? : A population-based study from Norway, Denmark and Iceland during the pre-vaccination era |
title_full |
Were cancer patients worse off than the general population during the COVID-19 pandemic? : A population-based study from Norway, Denmark and Iceland during the pre-vaccination era |
title_fullStr |
Were cancer patients worse off than the general population during the COVID-19 pandemic? : A population-based study from Norway, Denmark and Iceland during the pre-vaccination era |
title_full_unstemmed |
Were cancer patients worse off than the general population during the COVID-19 pandemic? : A population-based study from Norway, Denmark and Iceland during the pre-vaccination era |
title_sort |
were cancer patients worse off than the general population during the covid-19 pandemic? : a population-based study from norway, denmark and iceland during the pre-vaccination era |
publisher |
Uppsala universitet, Cancerimmunterapi |
publishDate |
2023 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-520215 https://doi.org/10.1016/j.lanepe.2023.100680 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
The Lancet Regional Health : Europe, 2023, 31, orcid:0000-0002-1191-7231 orcid:0000-0001-6506-2569 orcid:0000-0002-9625-2979 http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-520215 doi:10.1016/j.lanepe.2023.100680 PMID 37547277 ISI:001090629600001 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1016/j.lanepe.2023.100680 |
container_title |
The Lancet Regional Health - Europe |
container_volume |
31 |
container_start_page |
100680 |
_version_ |
1790601874279235584 |
spelling |
ftuppsalauniv:oai:DiVA.org:uu-520215 2024-02-11T10:05:02+01:00 Were cancer patients worse off than the general population during the COVID-19 pandemic? : A population-based study from Norway, Denmark and Iceland during the pre-vaccination era Johansson, Anna L., V Skog, Anna Johannesen, Tom Borge Myklebust, Tor age Skovlund, Charlotte Wessel Morch, Lina Steinrud Friis, Soren Gamborg, Mads Kristiansen, Marnar Frioheim Pettersson, David Olafsdottir, Elinborg J. Birgisson, Helgi Palsson, Runolfur Eythorsson, Elias Irenaeus, Sandra Lambe, Mats Ursin, Giske 2023 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-520215 https://doi.org/10.1016/j.lanepe.2023.100680 eng eng Uppsala universitet, Cancerimmunterapi Canc Registry Norway, POB 5313 Majorstuen, N-0304 Oslo, Norway.;Karolinska Inst, Dept Med Epidemiol & Biostat, POB 281, SE-17177 Stockholm, Sweden. Canc Registry Norway, POB 5313 Majorstuen, N-0304 Oslo, Norway. Canc Registry Norway, POB 5313 Majorstuen, N-0304 Oslo, Norway.;More & Romsdal Hosp Trust, Dept Res & Innovat, Alesund, Norway. Danish Canc Soc Res Ctr, Danish Canc Soc, Canc Surveillance & Pharmacoepidemiol, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. Fac Hlth Sci, Ctr Hlth Sci, Torshavn, Faroe Islands.;Natl Hosp Faroe Isl, Torshavn, Faroe Islands. Natl Board Hlth & Welf, SE-10630 Stockholm, Sweden. Iceland Canc Soc, ICS Res & Registrat Ctr, POB 5420, IS-105 Reykjavik, Iceland. Landspitali The Natl Univ Hosp Iceland, Saemundargata 2, IS-102 Reykjavik, Iceland.;Univ Iceland, Reykjavik, Iceland. Landspitali The Natl Univ Hosp Iceland, Saemundargata 2, IS-102 Reykjavik, Iceland. Akadem Sjukhuset, Reg Canc Ctr Cent Sweden, SE-75185 Uppsala, Sweden. Karolinska Inst, Dept Med Epidemiol & Biostat, POB 281, SE-17177 Stockholm, Sweden.;Akadem Sjukhuset, Reg Canc Ctr Cent Sweden, SE-75185 Uppsala, Sweden. Canc Registry Norway, POB 5313 Majorstuen, N-0304 Oslo, Norway.;Univ Oslo, Inst Basic Med Sci, Oslo, Norway.;Univ Southern Calif, Dept Prevent Med, Los Angeles, CA USA. The Lancet Regional Health : Europe, 2023, 31, orcid:0000-0002-1191-7231 orcid:0000-0001-6506-2569 orcid:0000-0002-9625-2979 http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-520215 doi:10.1016/j.lanepe.2023.100680 PMID 37547277 ISI:001090629600001 info:eu-repo/semantics/openAccess COVID-19 Coronavirus disease 2019 SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Cancer Hospitalisation Critical care outcomes Intensive care Mortality Nordic Denmark Norway Iceland Cancer and Oncology Cancer och onkologi Infectious Medicine Infektionsmedicin Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Article in journal info:eu-repo/semantics/article text 2023 ftuppsalauniv https://doi.org/10.1016/j.lanepe.2023.100680 2024-01-17T23:31:55Z Background In a population-based setting, we investigated the risks of testing positive for SARS-CoV-2 and developing severe COVID-19 outcomes among cancer patients compared with the general population.Methods In nationwide cohorts, we identified all individuals in Norway, Denmark and Iceland who tested positive for SARS-CoV-2 or had a severe COVID-19 outcome (hospitalisation, intensive care, and death) from March until December 2020, using data from national health registries. We estimated standardised incidence ratios (SIRs) with 95% confidence intervals (CIs) comparing cancer patients with the general population.Findings During the first wave of the pandemic, cancer patients in Norway and Denmark had higher risks of testing SARS-CoV-2 positive compared to the general population. Throughout 2020, recently treated cancer patients were more likely to test SARS-CoV-2 positive. In Iceland, cancer patients experienced no increased risk of testing positive. The risk of COVID-19-related hospitalisation was higher among cancer patients diagnosed within one year of hospitalisation (Norway: SIR = 2.43, 95% CI 1.89-3.09; Denmark: 2.23, 1.96-2.54) and within five years (Norway: 1.58, 1.35-1.83; Denmark: 1.54, 1.42-1.66). Risks were higher in recently treated cancer patients and in those diagnosed with haematologic malignancies, colorectal or lung cancer. Risks of COVID-19-related intensive care and death were higher among cancer patients. Interpretation Cancer patients were at increased risk of testing positive for SARS-CoV-2 during the first pandemic wave when testing availability was limited, while relative risks of severe COVID-19 outcomes remained increased in cancer patients throughout 2020. Recent cancer treatment and haematologic malignancy were the strongest risk factors. Article in Journal/Newspaper Iceland Uppsala University: Publications (DiVA) Norway The Lancet Regional Health - Europe 31 100680 |