Treatment Patterns, Socioeconomic Status and Clinical Burden in Mild COPD : A Swedish Real-World, Retrospective Cohort Study, the ARCTIC Study
Background: Patients with mild chronic obstructive pulmonary disease (COPD) account for more than half of the total COPD population but are often undiagnosed and sparsely studied. This real-world, longitudinal study compared the socioeconomic burden, clinical characteristics and treatment patterns i...
Published in: | International Journal of Chronic Obstructive Pulmonary Disease |
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Uppsala universitet, Centrum för klinisk forskning Dalarna
2022
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Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-480270 https://doi.org/10.2147/COPD.S364932 |
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ftuppsalauniv:oai:DiVA.org:uu-480270 2023-05-15T15:12:52+02:00 Treatment Patterns, Socioeconomic Status and Clinical Burden in Mild COPD : A Swedish Real-World, Retrospective Cohort Study, the ARCTIC Study Larsson, Kjell Lisspers, Karin Ställberg, Björn Johansson, Gunnar Gutzwiller, Florian S. Mezzi, Karen Bjerregaard, Bine Kjoeller Jorgensen, Leif Koo, Hyewon Janson, Christer 2022 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-480270 https://doi.org/10.2147/COPD.S364932 eng eng Uppsala universitet, Centrum för klinisk forskning Dalarna Uppsala universitet, Allmänmedicin och preventivmedicin Uppsala universitet, Lung- allergi- och sömnforskning Karolinska Inst, Natl Inst Environm Med, Integrat Toxicol, SE-17177 Stockholm, Sweden. Novartis Pharma AG, Basel, Switzerland. IQVIA Solut, Copenhagen, Denmark. IQVIA Solut, Solna, Sweden. Informa UK Limited The International Journal of Chronic Obstructive Pulmonary Disease, 1176-9106, 2022, 17, s. 1409-1421 orcid:0000-0002-3107-4462 orcid:0000-0001-8497-7326 orcid:0000-0001-9351-3881 orcid:0000-0001-5093-6980 http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-480270 doi:10.2147/COPD.S364932 PMID 35761954 ISI:000817118300001 info:eu-repo/semantics/openAccess chronic obstructive pulmonary disease socioeconomic status comorbidities co-medications annual income exacerbation Sweden Respiratory Medicine and Allergy Lungmedicin och allergi Article in journal info:eu-repo/semantics/article text 2022 ftuppsalauniv https://doi.org/10.2147/COPD.S364932 2023-02-23T21:59:50Z Background: Patients with mild chronic obstructive pulmonary disease (COPD) account for more than half of the total COPD population but are often undiagnosed and sparsely studied. This real-world, longitudinal study compared the socioeconomic burden, clinical characteristics and treatment patterns in patients with mild COPD and age-and gender-matched controls. Patients and methods: Our population included mild COPD patients (forced expiratory volume in one second >= 80% of predicted value) and reference controls from 52 Swedish primary care centres over 15 years (2000-2014). We linked electronic medical record (EMR) data to Sweden's National Health Registries. The outcomes analyzed were socioeconomic status including annual income from work, presence of comorbidities and the use of medications. Results: 844 patients with mild COPD were included in this study and matched with 844 reference controls. Compared with the reference controls, mild COPD patients had a significantly lower annual income from work (mean difference, men: 12,559 euro and women: 7143 euro ) and were significantly less likely to be married or employed. The presence of comorbidities, including cardiovascular disease, anxiety and depression (only women) was significantly higher in mild COPD patients. The use of medications, such as proton pump inhibitors, antidepressants, central painkillers and sleep medications, was significantly higher in the mild COPD group. Conclusion: Mild COPD presents a considerable socioeconomic and clinical burden compared with reference controls The findings suggest that COPD constitutes a condition that influences health status even in mild disease clearly demanding an increased need for early detection and treatment. Article in Journal/Newspaper Arctic Uppsala University: Publications (DiVA) Arctic International Journal of Chronic Obstructive Pulmonary Disease Volume 17 1409 1421 |
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Open Polar |
collection |
Uppsala University: Publications (DiVA) |
op_collection_id |
ftuppsalauniv |
language |
English |
topic |
chronic obstructive pulmonary disease socioeconomic status comorbidities co-medications annual income exacerbation Sweden Respiratory Medicine and Allergy Lungmedicin och allergi |
spellingShingle |
chronic obstructive pulmonary disease socioeconomic status comorbidities co-medications annual income exacerbation Sweden Respiratory Medicine and Allergy Lungmedicin och allergi Larsson, Kjell Lisspers, Karin Ställberg, Björn Johansson, Gunnar Gutzwiller, Florian S. Mezzi, Karen Bjerregaard, Bine Kjoeller Jorgensen, Leif Koo, Hyewon Janson, Christer Treatment Patterns, Socioeconomic Status and Clinical Burden in Mild COPD : A Swedish Real-World, Retrospective Cohort Study, the ARCTIC Study |
topic_facet |
chronic obstructive pulmonary disease socioeconomic status comorbidities co-medications annual income exacerbation Sweden Respiratory Medicine and Allergy Lungmedicin och allergi |
description |
Background: Patients with mild chronic obstructive pulmonary disease (COPD) account for more than half of the total COPD population but are often undiagnosed and sparsely studied. This real-world, longitudinal study compared the socioeconomic burden, clinical characteristics and treatment patterns in patients with mild COPD and age-and gender-matched controls. Patients and methods: Our population included mild COPD patients (forced expiratory volume in one second >= 80% of predicted value) and reference controls from 52 Swedish primary care centres over 15 years (2000-2014). We linked electronic medical record (EMR) data to Sweden's National Health Registries. The outcomes analyzed were socioeconomic status including annual income from work, presence of comorbidities and the use of medications. Results: 844 patients with mild COPD were included in this study and matched with 844 reference controls. Compared with the reference controls, mild COPD patients had a significantly lower annual income from work (mean difference, men: 12,559 euro and women: 7143 euro ) and were significantly less likely to be married or employed. The presence of comorbidities, including cardiovascular disease, anxiety and depression (only women) was significantly higher in mild COPD patients. The use of medications, such as proton pump inhibitors, antidepressants, central painkillers and sleep medications, was significantly higher in the mild COPD group. Conclusion: Mild COPD presents a considerable socioeconomic and clinical burden compared with reference controls The findings suggest that COPD constitutes a condition that influences health status even in mild disease clearly demanding an increased need for early detection and treatment. |
format |
Article in Journal/Newspaper |
author |
Larsson, Kjell Lisspers, Karin Ställberg, Björn Johansson, Gunnar Gutzwiller, Florian S. Mezzi, Karen Bjerregaard, Bine Kjoeller Jorgensen, Leif Koo, Hyewon Janson, Christer |
author_facet |
Larsson, Kjell Lisspers, Karin Ställberg, Björn Johansson, Gunnar Gutzwiller, Florian S. Mezzi, Karen Bjerregaard, Bine Kjoeller Jorgensen, Leif Koo, Hyewon Janson, Christer |
author_sort |
Larsson, Kjell |
title |
Treatment Patterns, Socioeconomic Status and Clinical Burden in Mild COPD : A Swedish Real-World, Retrospective Cohort Study, the ARCTIC Study |
title_short |
Treatment Patterns, Socioeconomic Status and Clinical Burden in Mild COPD : A Swedish Real-World, Retrospective Cohort Study, the ARCTIC Study |
title_full |
Treatment Patterns, Socioeconomic Status and Clinical Burden in Mild COPD : A Swedish Real-World, Retrospective Cohort Study, the ARCTIC Study |
title_fullStr |
Treatment Patterns, Socioeconomic Status and Clinical Burden in Mild COPD : A Swedish Real-World, Retrospective Cohort Study, the ARCTIC Study |
title_full_unstemmed |
Treatment Patterns, Socioeconomic Status and Clinical Burden in Mild COPD : A Swedish Real-World, Retrospective Cohort Study, the ARCTIC Study |
title_sort |
treatment patterns, socioeconomic status and clinical burden in mild copd : a swedish real-world, retrospective cohort study, the arctic study |
publisher |
Uppsala universitet, Centrum för klinisk forskning Dalarna |
publishDate |
2022 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-480270 https://doi.org/10.2147/COPD.S364932 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_relation |
The International Journal of Chronic Obstructive Pulmonary Disease, 1176-9106, 2022, 17, s. 1409-1421 orcid:0000-0002-3107-4462 orcid:0000-0001-8497-7326 orcid:0000-0001-9351-3881 orcid:0000-0001-5093-6980 http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-480270 doi:10.2147/COPD.S364932 PMID 35761954 ISI:000817118300001 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.2147/COPD.S364932 |
container_title |
International Journal of Chronic Obstructive Pulmonary Disease |
container_volume |
Volume 17 |
container_start_page |
1409 |
op_container_end_page |
1421 |
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1766343504292741120 |