Skeletal adverse events in childhood cancer survivors : An Adult Life after Childhood Cancer in Scandinavia cohort study
The dynamic growth of the skeleton during childhood and adolescence renders it vulnerable to adverse effects of cancer treatment. The lifetime risk and patterns of skeletal morbidity have not been described in a population-based cohort of childhood cancer survivors. A cohort of 26 334 1-year cancer...
Published in: | International Journal of Cancer |
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Main Authors: | , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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Uppsala universitet, Barnneurologi/Barnonkologi
2021
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Subjects: | |
Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-457651 https://doi.org/10.1002/ijc.33741 |
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ftuppsalauniv:oai:DiVA.org:uu-457651 |
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Uppsala University: Publications (DiVA) |
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language |
English |
topic |
ALiCCS childhood cancer late effects skeletal adverse events survivorship Cancer and Oncology Cancer och onkologi |
spellingShingle |
ALiCCS childhood cancer late effects skeletal adverse events survivorship Cancer and Oncology Cancer och onkologi Oskarsson, Trausti Duun-Henriksen, Anne Katrine Bautz, Andrea Montgomery, Scott Harila-Saari, Arja H. Petersen, Cecilia Niinimaki, Riitta Madanat-Harjuoja, Laura Tryggvadottir, Laufey Holmqvist, Anna Sällfors Hasle, Henrik Heyman, Mats Winther, Jeanette Falck Skeletal adverse events in childhood cancer survivors : An Adult Life after Childhood Cancer in Scandinavia cohort study |
topic_facet |
ALiCCS childhood cancer late effects skeletal adverse events survivorship Cancer and Oncology Cancer och onkologi |
description |
The dynamic growth of the skeleton during childhood and adolescence renders it vulnerable to adverse effects of cancer treatment. The lifetime risk and patterns of skeletal morbidity have not been described in a population-based cohort of childhood cancer survivors. A cohort of 26 334 1-year cancer survivors diagnosed before 20 years of age was identified from the national cancer registries of Denmark, Finland, Iceland and Sweden as well as a cohort of 127 531 age- and sex-matched comparison subjects randomly selected from the national population registries in each country. The two cohorts were linked with data from the national hospital registries and the observed numbers of first-time hospital admissions for adverse skeletal outcomes among childhood cancer survivors were compared to the expected numbers derived from the comparison cohort. In total, 1987 childhood cancer survivors had at least one hospital admission with a skeletal adverse event as discharge diagnosis, yielding a rate ratio (RR) of 1.35 (95% confidence interval, 1.29-1.42). Among the survivors, we observed an increased risk for osteonecrosis with a RR of 25.9 (15.0-44.5), osteoporosis, RR 4.53 (3.28-6.27), fractures, RR 1.27 (1.20-1.34), osteochondropathies, RR 1.57 (1.28-1.92) and osteoarthrosis, RR 1.48 (1.28-1.72). The hospitalization risk for any skeletal adverse event was higher among survivors up to the age of 60 years, but the lifetime pattern was different for each type of skeletal adverse event. Understanding the different lifetime patterns and identification of high-risk groups is crucial for developing strategies to optimize skeletal health in childhood cancer survivors. |
format |
Article in Journal/Newspaper |
author |
Oskarsson, Trausti Duun-Henriksen, Anne Katrine Bautz, Andrea Montgomery, Scott Harila-Saari, Arja H. Petersen, Cecilia Niinimaki, Riitta Madanat-Harjuoja, Laura Tryggvadottir, Laufey Holmqvist, Anna Sällfors Hasle, Henrik Heyman, Mats Winther, Jeanette Falck |
author_facet |
Oskarsson, Trausti Duun-Henriksen, Anne Katrine Bautz, Andrea Montgomery, Scott Harila-Saari, Arja H. Petersen, Cecilia Niinimaki, Riitta Madanat-Harjuoja, Laura Tryggvadottir, Laufey Holmqvist, Anna Sällfors Hasle, Henrik Heyman, Mats Winther, Jeanette Falck |
author_sort |
Oskarsson, Trausti |
title |
Skeletal adverse events in childhood cancer survivors : An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_short |
Skeletal adverse events in childhood cancer survivors : An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_full |
Skeletal adverse events in childhood cancer survivors : An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_fullStr |
Skeletal adverse events in childhood cancer survivors : An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_full_unstemmed |
Skeletal adverse events in childhood cancer survivors : An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_sort |
skeletal adverse events in childhood cancer survivors : an adult life after childhood cancer in scandinavia cohort study |
publisher |
Uppsala universitet, Barnneurologi/Barnonkologi |
publishDate |
2021 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-457651 https://doi.org/10.1002/ijc.33741 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
International Journal of Cancer, 0020-7136, 2021, 149:11, s. 1863-1876 orcid:0000-0003-2767-5828 http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-457651 doi:10.1002/ijc.33741 PMID 34278568 ISI:000703622600005 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1002/ijc.33741 |
container_title |
International Journal of Cancer |
container_volume |
149 |
container_issue |
11 |
container_start_page |
1863 |
op_container_end_page |
1876 |
_version_ |
1790602139666481152 |
spelling |
ftuppsalauniv:oai:DiVA.org:uu-457651 2024-02-11T10:05:14+01:00 Skeletal adverse events in childhood cancer survivors : An Adult Life after Childhood Cancer in Scandinavia cohort study Oskarsson, Trausti Duun-Henriksen, Anne Katrine Bautz, Andrea Montgomery, Scott Harila-Saari, Arja H. Petersen, Cecilia Niinimaki, Riitta Madanat-Harjuoja, Laura Tryggvadottir, Laufey Holmqvist, Anna Sällfors Hasle, Henrik Heyman, Mats Winther, Jeanette Falck 2021 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-457651 https://doi.org/10.1002/ijc.33741 eng eng Uppsala universitet, Barnneurologi/Barnonkologi Astrid Lindgren Childrens Hosp, Dept Paediat Oncol, Stockholm, Sweden.;Karolinska Inst, Dept Womens & Childrens Hlth, Childhood Canc Res Unit, Stockholm, Sweden. Danish Canc Soc Res Ctr, Childhood Canc Res Grp, Copenhagen, Denmark. Örebro Univ, Sch Med Sci, Clin Epidemiol & Biostat, Örebro, Sweden.;Karolinska Univ Hosp, Karolinska Inst, Div Clin Epidemiol, Stockholm, Sweden.;UCL, Dept Epidemiol & Publ Hlth, London, England. Karolinska Inst, Dept Womens & Childrens Hlth, Childhood Canc Res Unit, Stockholm, Sweden. Astrid Lindgren Childrens Hosp, Dept Paediat Oncol, Stockholm, Sweden. Oulu Univ Hosp, Dept Children & Adolescents, Oulu, Finland. Finnish Canc Registry, Finnish Inst Stat & Epidemiol Canc Res, Helsinki, Finland.;Harvard Med Sch, Boston Childrens Canc & Blood Disorders Ctr, Dana Farber Canc Inst, Boston, MA 02115 USA.;Univ Helsinki, Dept Pediat, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland. Iceland Canc Soc, Iceland Canc Registry, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland. Skane Univ Hosp, Div Paediat Oncol & Haematol, Lund, Sweden.;Lund Univ, Dept Clin Sci, Lund, Sweden. Aarhus Univ Hosp, Dept Paediat, Aarhus, Denmark. Danish Canc Soc Res Ctr, Childhood Canc Res Grp, Copenhagen, Denmark.;Aarhus Univ, Fac Hlth, Dept Clin Med, Aarhus, Denmark.;Univ Hosp, Aarhus, Denmark. WILEY International Journal of Cancer, 0020-7136, 2021, 149:11, s. 1863-1876 orcid:0000-0003-2767-5828 http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-457651 doi:10.1002/ijc.33741 PMID 34278568 ISI:000703622600005 info:eu-repo/semantics/openAccess ALiCCS childhood cancer late effects skeletal adverse events survivorship Cancer and Oncology Cancer och onkologi Article in journal info:eu-repo/semantics/article text 2021 ftuppsalauniv https://doi.org/10.1002/ijc.33741 2024-01-17T23:32:49Z The dynamic growth of the skeleton during childhood and adolescence renders it vulnerable to adverse effects of cancer treatment. The lifetime risk and patterns of skeletal morbidity have not been described in a population-based cohort of childhood cancer survivors. A cohort of 26 334 1-year cancer survivors diagnosed before 20 years of age was identified from the national cancer registries of Denmark, Finland, Iceland and Sweden as well as a cohort of 127 531 age- and sex-matched comparison subjects randomly selected from the national population registries in each country. The two cohorts were linked with data from the national hospital registries and the observed numbers of first-time hospital admissions for adverse skeletal outcomes among childhood cancer survivors were compared to the expected numbers derived from the comparison cohort. In total, 1987 childhood cancer survivors had at least one hospital admission with a skeletal adverse event as discharge diagnosis, yielding a rate ratio (RR) of 1.35 (95% confidence interval, 1.29-1.42). Among the survivors, we observed an increased risk for osteonecrosis with a RR of 25.9 (15.0-44.5), osteoporosis, RR 4.53 (3.28-6.27), fractures, RR 1.27 (1.20-1.34), osteochondropathies, RR 1.57 (1.28-1.92) and osteoarthrosis, RR 1.48 (1.28-1.72). The hospitalization risk for any skeletal adverse event was higher among survivors up to the age of 60 years, but the lifetime pattern was different for each type of skeletal adverse event. Understanding the different lifetime patterns and identification of high-risk groups is crucial for developing strategies to optimize skeletal health in childhood cancer survivors. Article in Journal/Newspaper Iceland Uppsala University: Publications (DiVA) International Journal of Cancer 149 11 1863 1876 |