Paternal grandfather's access to food predicts all-cause and cancer mortality in grandsons

• Published in: Nature Communications
• Main Authors: Vagero, Denny, Pinger, Pia R., Aronsson, Vanda, van den Berg, Gerard J.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Uppsala universitet, Institutet för arbetsmarknadspolitisk utvärdering (IFAU) 2018
• Subjects: Public Health; Global Health; Social Medicine and Epidemiology; Folkhälsovetenskap; global hälsa; socialmedicin och epidemiologi; Northern Sweden
• Online Access: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-372940; https://doi.org/10.1038/s41467-018-07617-9

Studies of animals and plants suggest that nutritional conditions in one generation may affect phenotypic characteristics in subsequent generations. A small number of human studies claim to show that pre-pubertal nutritional experience trigger a sex-specific transgenerational response along the male line. A single historical dataset, the Overkalix cohorts in northern Sweden, is often quoted as evidence. To test this hypothesis on an almost 40 times larger dataset we collect harvest data during the pre-pubertal period of grandparents (G0, n = 9,039) to examine its potential association with mortality in children (G1, n = 7,280) and grandchildren (G2, n = 11,561) in the Uppsala Multigeneration Study. We find support for the main Overkalix finding: paternal grandfather's food access in pre-puberty predicts his male, but not female, grandchildren's all-cause mortality. In our study, cancer mortality contributes strongly to this pattern. We are unable to reproduce previous results for diabetes and cardiovascular mortality.