Therapeutic and functional studies in animal models of Alzheimer's disease

• Main Author: Gumucio, Astrid
• Format: Doctoral or Postdoctoral Thesis
• Language: English
• Published: Uppsala universitet, Geriatrik 2014
• Subjects: Alzheimer's disease; Amyloid-beta; Immunotherapy; IntelliCage; Microtubule; Tau; Alternative splicing; Neurosciences; Neurovetenskaper; Microbiology in the medical area; Mikrobiologi inom det medicinska området; Arctic; Perseverance
• Online Access: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-223135

Senile plaques (Aβ) and neurofibrillary tangles (tau) are pathological hallmarks of Alzheimer’s disease (AD). If and how the formation of these deposits are mechanistically linked remains mainly unknown. In recent years, the focus has shifted from insoluble protein deposits to soluble aggregates of...