Changes in regional brain monoaminergic activity and temporary down-regulation in stress response from dietary supplementation with L-tryptophan in Atlantic cod (Gadus morhua)
The brain monoamines serotonin (5-hydroxytryptamine; 5-HT) and dopamine (DA) both play an integrative role in behavioural and neuroendocrine responses to challenges, and comparative models suggest common mechanisms for dietary modulation of transmission by these signal substances in vertebrates. Pre...
Published in: | British Journal of Nutrition |
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Uppsala universitet, Fysiologi
2013
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Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-203263 https://doi.org/10.1017/S0007114512004345 |
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ftuppsalauniv:oai:DiVA.org:uu-203263 2023-05-15T15:27:07+02:00 Changes in regional brain monoaminergic activity and temporary down-regulation in stress response from dietary supplementation with L-tryptophan in Atlantic cod (Gadus morhua) Basic, Dean Schjolden, Joachim Krogdahl, Ashild von Krogh, Kristine Hillestad, Marie Winberg, Svante Mayer, Ian Skjerve, Eystein Hoglund, Erik 2013 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-203263 https://doi.org/10.1017/S0007114512004345 eng eng Uppsala universitet, Fysiologi British Journal of Nutrition, 0007-1145, 2013, 109:12, s. 2166-2174 http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-203263 doi:10.1017/S0007114512004345 ISI:000319608300006 info:eu-repo/semantics/openAccess Tryptophan Atlantic cod Stress response Nucleus lateralis tuberis Lateral pallial telencephalon Medical and Health Sciences Medicin och hälsovetenskap Article in journal info:eu-repo/semantics/article text 2013 ftuppsalauniv https://doi.org/10.1017/S0007114512004345 2023-02-23T21:45:30Z The brain monoamines serotonin (5-hydroxytryptamine; 5-HT) and dopamine (DA) both play an integrative role in behavioural and neuroendocrine responses to challenges, and comparative models suggest common mechanisms for dietary modulation of transmission by these signal substances in vertebrates. Previous studies in teleosts demonstrate that 7 d of dietary administration with L-tryptophan (Trp), the direct precursor of 5-HT, suppresses the endocrine stress response. The present study investigated how long the suppressive effects of a Trp-enriched feed regimen, at doses corresponding to two, three or four times the Trp levels in commercial feed, last in juvenile Atlantic cod (Gadus morhua) when the fish are reintroduced to a diet with standard amino acid composition. We also wanted to determine whether Trp supplementation induced changes in brain monoaminergic neurochemistry in those forebrain structures innervated by DA- and 5-HTergic neurons, by measuring regional activity of DA and 5-HT in the lateral pallial regions (Dl) of the telencephalon and nucleus lateralis tuberis (NLT) of the hypothalamus. Dietary Trp resulted in a dose-dependent suppression in plasma cortisol among fish exposed to confinement stress on the first day following experimental diet; however, such an effect was not observed at 2 or 6 d after Trp treatment. Feeding the fish with moderate Trp doses also evoked a general increase in DA and 5-HT-ergic activity, suggesting that these neural circuits within the NLT and Dl may be indirectly involved in regulating the acute stress response. Article in Journal/Newspaper atlantic cod Gadus morhua Uppsala University: Publications (DiVA) British Journal of Nutrition 109 12 2166 2174 |
institution |
Open Polar |
collection |
Uppsala University: Publications (DiVA) |
op_collection_id |
ftuppsalauniv |
language |
English |
topic |
Tryptophan Atlantic cod Stress response Nucleus lateralis tuberis Lateral pallial telencephalon Medical and Health Sciences Medicin och hälsovetenskap |
spellingShingle |
Tryptophan Atlantic cod Stress response Nucleus lateralis tuberis Lateral pallial telencephalon Medical and Health Sciences Medicin och hälsovetenskap Basic, Dean Schjolden, Joachim Krogdahl, Ashild von Krogh, Kristine Hillestad, Marie Winberg, Svante Mayer, Ian Skjerve, Eystein Hoglund, Erik Changes in regional brain monoaminergic activity and temporary down-regulation in stress response from dietary supplementation with L-tryptophan in Atlantic cod (Gadus morhua) |
topic_facet |
Tryptophan Atlantic cod Stress response Nucleus lateralis tuberis Lateral pallial telencephalon Medical and Health Sciences Medicin och hälsovetenskap |
description |
The brain monoamines serotonin (5-hydroxytryptamine; 5-HT) and dopamine (DA) both play an integrative role in behavioural and neuroendocrine responses to challenges, and comparative models suggest common mechanisms for dietary modulation of transmission by these signal substances in vertebrates. Previous studies in teleosts demonstrate that 7 d of dietary administration with L-tryptophan (Trp), the direct precursor of 5-HT, suppresses the endocrine stress response. The present study investigated how long the suppressive effects of a Trp-enriched feed regimen, at doses corresponding to two, three or four times the Trp levels in commercial feed, last in juvenile Atlantic cod (Gadus morhua) when the fish are reintroduced to a diet with standard amino acid composition. We also wanted to determine whether Trp supplementation induced changes in brain monoaminergic neurochemistry in those forebrain structures innervated by DA- and 5-HTergic neurons, by measuring regional activity of DA and 5-HT in the lateral pallial regions (Dl) of the telencephalon and nucleus lateralis tuberis (NLT) of the hypothalamus. Dietary Trp resulted in a dose-dependent suppression in plasma cortisol among fish exposed to confinement stress on the first day following experimental diet; however, such an effect was not observed at 2 or 6 d after Trp treatment. Feeding the fish with moderate Trp doses also evoked a general increase in DA and 5-HT-ergic activity, suggesting that these neural circuits within the NLT and Dl may be indirectly involved in regulating the acute stress response. |
format |
Article in Journal/Newspaper |
author |
Basic, Dean Schjolden, Joachim Krogdahl, Ashild von Krogh, Kristine Hillestad, Marie Winberg, Svante Mayer, Ian Skjerve, Eystein Hoglund, Erik |
author_facet |
Basic, Dean Schjolden, Joachim Krogdahl, Ashild von Krogh, Kristine Hillestad, Marie Winberg, Svante Mayer, Ian Skjerve, Eystein Hoglund, Erik |
author_sort |
Basic, Dean |
title |
Changes in regional brain monoaminergic activity and temporary down-regulation in stress response from dietary supplementation with L-tryptophan in Atlantic cod (Gadus morhua) |
title_short |
Changes in regional brain monoaminergic activity and temporary down-regulation in stress response from dietary supplementation with L-tryptophan in Atlantic cod (Gadus morhua) |
title_full |
Changes in regional brain monoaminergic activity and temporary down-regulation in stress response from dietary supplementation with L-tryptophan in Atlantic cod (Gadus morhua) |
title_fullStr |
Changes in regional brain monoaminergic activity and temporary down-regulation in stress response from dietary supplementation with L-tryptophan in Atlantic cod (Gadus morhua) |
title_full_unstemmed |
Changes in regional brain monoaminergic activity and temporary down-regulation in stress response from dietary supplementation with L-tryptophan in Atlantic cod (Gadus morhua) |
title_sort |
changes in regional brain monoaminergic activity and temporary down-regulation in stress response from dietary supplementation with l-tryptophan in atlantic cod (gadus morhua) |
publisher |
Uppsala universitet, Fysiologi |
publishDate |
2013 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-203263 https://doi.org/10.1017/S0007114512004345 |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_relation |
British Journal of Nutrition, 0007-1145, 2013, 109:12, s. 2166-2174 http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-203263 doi:10.1017/S0007114512004345 ISI:000319608300006 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1017/S0007114512004345 |
container_title |
British Journal of Nutrition |
container_volume |
109 |
container_issue |
12 |
container_start_page |
2166 |
op_container_end_page |
2174 |
_version_ |
1766357578613260288 |