Metabolic Aspects in the Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of childbearing age and is associated with a number of metabolic disturbances. It has been hypothesised these women carry an increased risk of developing cardiovascular diseases (CVD) with advancing age. The f...
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Uppsala universitet, Institutionen för kvinnors och barns hälsa
2010
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ftuppsalauniv:oai:DiVA.org:uu-120235 2023-05-15T17:44:32+02:00 Metabolic Aspects in the Polycystic Ovary Syndrome Lindholm, Åsa Maria 2010 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120235 eng eng Uppsala universitet, Institutionen för kvinnors och barns hälsa Uppsala : Acta Universitatis Upsaliensis Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1651-6206 534 http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120235 urn:isbn:978-91-554-7746-2 info:eu-repo/semantics/openAccess PCOS prevalence fibrinolysis inflammatory markers over weight Obstetrics and gynaecology Obstetrik och gynekologi Doctoral thesis, comprehensive summary info:eu-repo/semantics/doctoralThesis text 2010 ftuppsalauniv 2023-02-23T21:43:47Z Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of childbearing age and is associated with a number of metabolic disturbances. It has been hypothesised these women carry an increased risk of developing cardiovascular diseases (CVD) with advancing age. The first aim of this thesis was to establish the prevalence of PCOS-related symptoms in Northern Sweden. The Northern part of the WHO MONICA project was used for this purpose. Based on self-reported menstrual disturbances and hirsutism together with biochemical analyses of free androgen index, the estimated prevalence of PCOS in Northern Sweden was 4.8%, which corresponded with previous prevalence studies. Disturbances in the fibrinolytic system are predictors of future cardiovascular events and measurements of plasminogen activator inhibitor 1 (PAI-1) activity and tissue plasminogen activator (tPA) mass concentration may be used to assess fibrinolytic activity in women with PCOS. From the findings, over-weight women with PCOS had impaired fibrinolysis, especially if they displayed objective biochemical markers of hyperandrogenism. Conversely, lean women with PCOS, displayed no signs of disturbed fibrinolysis. The adipose tissue is an active endocrine organ that produces and releases hormones, pro- and anti-inflammatory cytokines, and chemoattractant cytokines. Proinflammatory molecules produced by adipose tissue can be active participants in the development of insulin resistance and the increased risk of cardiovascular disease associated with obesity. The findings suggested being overweight, rather than the PCOS diagnosis per se, was the main explanatory variable for elevated adipose tissue inflammation in PCOS patients. Weight reduction is the primary target for intervention in overweight and obese women with PCOS. When this thesis was planned, no placebo-controlled trials on anti-obesity drugs in women with PCOS had been conducted. Sibutramine in combination with lifestyle intervention resulted in significant weight ... Doctoral or Postdoctoral Thesis Northern Sweden Uppsala University: Publications (DiVA) |
institution |
Open Polar |
collection |
Uppsala University: Publications (DiVA) |
op_collection_id |
ftuppsalauniv |
language |
English |
topic |
PCOS prevalence fibrinolysis inflammatory markers over weight Obstetrics and gynaecology Obstetrik och gynekologi |
spellingShingle |
PCOS prevalence fibrinolysis inflammatory markers over weight Obstetrics and gynaecology Obstetrik och gynekologi Lindholm, Åsa Maria Metabolic Aspects in the Polycystic Ovary Syndrome |
topic_facet |
PCOS prevalence fibrinolysis inflammatory markers over weight Obstetrics and gynaecology Obstetrik och gynekologi |
description |
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of childbearing age and is associated with a number of metabolic disturbances. It has been hypothesised these women carry an increased risk of developing cardiovascular diseases (CVD) with advancing age. The first aim of this thesis was to establish the prevalence of PCOS-related symptoms in Northern Sweden. The Northern part of the WHO MONICA project was used for this purpose. Based on self-reported menstrual disturbances and hirsutism together with biochemical analyses of free androgen index, the estimated prevalence of PCOS in Northern Sweden was 4.8%, which corresponded with previous prevalence studies. Disturbances in the fibrinolytic system are predictors of future cardiovascular events and measurements of plasminogen activator inhibitor 1 (PAI-1) activity and tissue plasminogen activator (tPA) mass concentration may be used to assess fibrinolytic activity in women with PCOS. From the findings, over-weight women with PCOS had impaired fibrinolysis, especially if they displayed objective biochemical markers of hyperandrogenism. Conversely, lean women with PCOS, displayed no signs of disturbed fibrinolysis. The adipose tissue is an active endocrine organ that produces and releases hormones, pro- and anti-inflammatory cytokines, and chemoattractant cytokines. Proinflammatory molecules produced by adipose tissue can be active participants in the development of insulin resistance and the increased risk of cardiovascular disease associated with obesity. The findings suggested being overweight, rather than the PCOS diagnosis per se, was the main explanatory variable for elevated adipose tissue inflammation in PCOS patients. Weight reduction is the primary target for intervention in overweight and obese women with PCOS. When this thesis was planned, no placebo-controlled trials on anti-obesity drugs in women with PCOS had been conducted. Sibutramine in combination with lifestyle intervention resulted in significant weight ... |
format |
Doctoral or Postdoctoral Thesis |
author |
Lindholm, Åsa Maria |
author_facet |
Lindholm, Åsa Maria |
author_sort |
Lindholm, Åsa Maria |
title |
Metabolic Aspects in the Polycystic Ovary Syndrome |
title_short |
Metabolic Aspects in the Polycystic Ovary Syndrome |
title_full |
Metabolic Aspects in the Polycystic Ovary Syndrome |
title_fullStr |
Metabolic Aspects in the Polycystic Ovary Syndrome |
title_full_unstemmed |
Metabolic Aspects in the Polycystic Ovary Syndrome |
title_sort |
metabolic aspects in the polycystic ovary syndrome |
publisher |
Uppsala universitet, Institutionen för kvinnors och barns hälsa |
publishDate |
2010 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120235 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1651-6206 534 http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120235 urn:isbn:978-91-554-7746-2 |
op_rights |
info:eu-repo/semantics/openAccess |
_version_ |
1766146770173165568 |