Prenatal and postnatal PCB-153 and p,p′ -DDE exposures and behavior scores at 5–9 years of age among children in Greenland and Ukraine
BACKGROUND: Studies have reported some evidence of adverse effects of organochlorine exposures on child development, but the results have been inconsistent, and few studies have evaluated associations with child behavior. OBJECTIVE: We investigated the association between prenatal and early-life exp...
Published in: | Environmental Health Perspectives |
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National Institute of Environmental Health Sciences
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Online Access: | http://hdl.handle.net/10230/34030 https://doi.org/10.1289/EHP553 |
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UPF Digital Repository (Universitat Pompeu Fabra, Barcelona) |
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ftupompeufabra |
language |
English |
topic |
Dichlorodiphenyl dichloroethylene/blood Polychlorinated biphenyls/blood Child development Child behavior Environmental exposure Environmental pollutants/blood |
spellingShingle |
Dichlorodiphenyl dichloroethylene/blood Polychlorinated biphenyls/blood Child development Child behavior Environmental exposure Environmental pollutants/blood Rosenquist, Aske Hess Hoyer, Birgit Bjerre Júlvez Calvo, Jordi Sunyer Deu, Jordi Pedersen, Henning Sloth Lenters, Virissa Jönsson, Bo A.G. Bonde, Jens Peter Toft, Gunnar Prenatal and postnatal PCB-153 and p,p′ -DDE exposures and behavior scores at 5–9 years of age among children in Greenland and Ukraine |
topic_facet |
Dichlorodiphenyl dichloroethylene/blood Polychlorinated biphenyls/blood Child development Child behavior Environmental exposure Environmental pollutants/blood |
description |
BACKGROUND: Studies have reported some evidence of adverse effects of organochlorine exposures on child development, but the results have been inconsistent, and few studies have evaluated associations with child behavior. OBJECTIVE: We investigated the association between prenatal and early-life exposures to 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE) and behaviors in children between 5 and 9 y of age. METHODS: In the Biopersistent organochlorines in diet and human fertility: Epidemiologic studies of time to pregnancy and semen quality in Inuit and European populations (INUENDO) cohort, consisting of mother-child pairs from Greenland and Ukraine (n=1,018), maternal serum PCB-153 and p,p'-DDE concentrations were measured during pregnancy, and cumulative postnatal exposures during the first 12 months after delivery were estimated using a pharmacokinetic model. Parents completed the Strengths and Difficulties Questionnaire (SDQ), and children's behaviors were dichotomized as abnormal (high) versus normal/borderline for five SDQ subscales and the total difficulties score. RESULTS: The total difficulties score, an overall measure of abnormal behavior, was not clearly associated with pre- or postnatal exposures to PCB-153 or to p,p'-DDE. However, pooled adjusted odds ratios (ORs) for high conduct problem scores with a doubling of exposure were 1.19 (95% CI: 0.99, 1.42) and 1.16 (95% CI: 0.96, 1.41) for pre- and postnatal PCB-153, respectively, and 1.25 (95% CI: 1.04, 1.51) and 1.24 (95% CI: 1.01, 1.51) for pre- and postnatal p,p'-DDE, respectively. Corresponding ORs for high hyperactivity scores were 1.24 (95% CI: 0.94, 1.62) and 1.08 (95% CI: 0.81, 1.45) for pre- and postnatal PCB-153, respectively, and 1.43 (95% CI: 1.06, 1.92) and 1.27 (95% CI: 0.93, 1.73) for pre- and postnatal p,p'-DDE, respectively. CONCLUSION: Prenatal and early postnatal exposures to p,p'-DDE and PCB-153 were associated with a higher prevalence of abnormal scores for conduct and hyperactivity at 5-9 y of age in our study population. These findings provide further support for the importance of minimizing organochlorine exposures to young children and to women of childbearing age. https://doi.org/10.1289/EHP553. The Climate change, environmental contaminants and reproductive health (CLEAR) and Biopersistent organochlorines in diet and human fertility: Epidemiologic studies of time to pregnancy and semen quality in Inuit and European populations (INUENDO) studies were funded by the European Commission's 7th and 5th Framework Programmes, respectively (grant nos. FP7-ENV-2008-1-226217 and QLK4-CT-2001-00202, respectively). A.H.R. received grants from The Danish Council for Independent Research - Medical Sciences (5053-00064A), the A.P. Møller Foundation (15-338), the Oticon Foundation (15-3689), and the Spar Nord Foundation. |
format |
Article in Journal/Newspaper |
author |
Rosenquist, Aske Hess Hoyer, Birgit Bjerre Júlvez Calvo, Jordi Sunyer Deu, Jordi Pedersen, Henning Sloth Lenters, Virissa Jönsson, Bo A.G. Bonde, Jens Peter Toft, Gunnar |
author_facet |
Rosenquist, Aske Hess Hoyer, Birgit Bjerre Júlvez Calvo, Jordi Sunyer Deu, Jordi Pedersen, Henning Sloth Lenters, Virissa Jönsson, Bo A.G. Bonde, Jens Peter Toft, Gunnar |
author_sort |
Rosenquist, Aske Hess |
title |
Prenatal and postnatal PCB-153 and p,p′ -DDE exposures and behavior scores at 5–9 years of age among children in Greenland and Ukraine |
title_short |
Prenatal and postnatal PCB-153 and p,p′ -DDE exposures and behavior scores at 5–9 years of age among children in Greenland and Ukraine |
title_full |
Prenatal and postnatal PCB-153 and p,p′ -DDE exposures and behavior scores at 5–9 years of age among children in Greenland and Ukraine |
title_fullStr |
Prenatal and postnatal PCB-153 and p,p′ -DDE exposures and behavior scores at 5–9 years of age among children in Greenland and Ukraine |
title_full_unstemmed |
Prenatal and postnatal PCB-153 and p,p′ -DDE exposures and behavior scores at 5–9 years of age among children in Greenland and Ukraine |
title_sort |
prenatal and postnatal pcb-153 and p,p′ -dde exposures and behavior scores at 5–9 years of age among children in greenland and ukraine |
publisher |
National Institute of Environmental Health Sciences |
url |
http://hdl.handle.net/10230/34030 https://doi.org/10.1289/EHP553 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuit |
genre_facet |
Greenland inuit |
op_relation |
Environ Health Perspect. 2017 Oct 3;125(10):107002 info:eu-repo/grantAgreement/EC/FP7/226217 Rosenquist AH, Høyer BB, Julvez J, Sunyer J, Pedersen HS, Lenters V et al. Prenatal and postnatal PCB-153 and p,p′ -DDE exposures and behavior scores at 5–9 years of age among children in Greenland and Ukraine. Environ Health Perspect. 2017 Oct 3;125(10):107002. DOI:10.1289/EHP553 0091-6765 http://hdl.handle.net/10230/34030 http://dx.doi.org/10.1289/EHP553 |
op_rights |
Reproduced from Environmental Health Perspectives http://dx.doi.org/10.1289/EHP553 info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1289/EHP553 |
container_title |
Environmental Health Perspectives |
container_volume |
125 |
container_issue |
10 |
container_start_page |
107002 |
_version_ |
1766019247849340928 |
spelling |
ftupompeufabra:oai:repositori.upf.edu:10230/34030 2023-05-15T16:29:33+02:00 Prenatal and postnatal PCB-153 and p,p′ -DDE exposures and behavior scores at 5–9 years of age among children in Greenland and Ukraine Rosenquist, Aske Hess Hoyer, Birgit Bjerre Júlvez Calvo, Jordi Sunyer Deu, Jordi Pedersen, Henning Sloth Lenters, Virissa Jönsson, Bo A.G. Bonde, Jens Peter Toft, Gunnar application/pdf http://hdl.handle.net/10230/34030 https://doi.org/10.1289/EHP553 eng eng National Institute of Environmental Health Sciences Environ Health Perspect. 2017 Oct 3;125(10):107002 info:eu-repo/grantAgreement/EC/FP7/226217 Rosenquist AH, Høyer BB, Julvez J, Sunyer J, Pedersen HS, Lenters V et al. Prenatal and postnatal PCB-153 and p,p′ -DDE exposures and behavior scores at 5–9 years of age among children in Greenland and Ukraine. Environ Health Perspect. 2017 Oct 3;125(10):107002. DOI:10.1289/EHP553 0091-6765 http://hdl.handle.net/10230/34030 http://dx.doi.org/10.1289/EHP553 Reproduced from Environmental Health Perspectives http://dx.doi.org/10.1289/EHP553 info:eu-repo/semantics/openAccess Dichlorodiphenyl dichloroethylene/blood Polychlorinated biphenyls/blood Child development Child behavior Environmental exposure Environmental pollutants/blood info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion ftupompeufabra https://doi.org/10.1289/EHP553 2021-08-03T23:18:35Z BACKGROUND: Studies have reported some evidence of adverse effects of organochlorine exposures on child development, but the results have been inconsistent, and few studies have evaluated associations with child behavior. OBJECTIVE: We investigated the association between prenatal and early-life exposures to 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE) and behaviors in children between 5 and 9 y of age. METHODS: In the Biopersistent organochlorines in diet and human fertility: Epidemiologic studies of time to pregnancy and semen quality in Inuit and European populations (INUENDO) cohort, consisting of mother-child pairs from Greenland and Ukraine (n=1,018), maternal serum PCB-153 and p,p'-DDE concentrations were measured during pregnancy, and cumulative postnatal exposures during the first 12 months after delivery were estimated using a pharmacokinetic model. Parents completed the Strengths and Difficulties Questionnaire (SDQ), and children's behaviors were dichotomized as abnormal (high) versus normal/borderline for five SDQ subscales and the total difficulties score. RESULTS: The total difficulties score, an overall measure of abnormal behavior, was not clearly associated with pre- or postnatal exposures to PCB-153 or to p,p'-DDE. However, pooled adjusted odds ratios (ORs) for high conduct problem scores with a doubling of exposure were 1.19 (95% CI: 0.99, 1.42) and 1.16 (95% CI: 0.96, 1.41) for pre- and postnatal PCB-153, respectively, and 1.25 (95% CI: 1.04, 1.51) and 1.24 (95% CI: 1.01, 1.51) for pre- and postnatal p,p'-DDE, respectively. Corresponding ORs for high hyperactivity scores were 1.24 (95% CI: 0.94, 1.62) and 1.08 (95% CI: 0.81, 1.45) for pre- and postnatal PCB-153, respectively, and 1.43 (95% CI: 1.06, 1.92) and 1.27 (95% CI: 0.93, 1.73) for pre- and postnatal p,p'-DDE, respectively. CONCLUSION: Prenatal and early postnatal exposures to p,p'-DDE and PCB-153 were associated with a higher prevalence of abnormal scores for conduct and hyperactivity at 5-9 y of age in our study population. These findings provide further support for the importance of minimizing organochlorine exposures to young children and to women of childbearing age. https://doi.org/10.1289/EHP553. The Climate change, environmental contaminants and reproductive health (CLEAR) and Biopersistent organochlorines in diet and human fertility: Epidemiologic studies of time to pregnancy and semen quality in Inuit and European populations (INUENDO) studies were funded by the European Commission's 7th and 5th Framework Programmes, respectively (grant nos. FP7-ENV-2008-1-226217 and QLK4-CT-2001-00202, respectively). A.H.R. received grants from The Danish Council for Independent Research - Medical Sciences (5053-00064A), the A.P. Møller Foundation (15-338), the Oticon Foundation (15-3689), and the Spar Nord Foundation. Article in Journal/Newspaper Greenland inuit UPF Digital Repository (Universitat Pompeu Fabra, Barcelona) Greenland Environmental Health Perspectives 125 10 107002 |