Interactions between metabolism of trace metals and xenobiotic agonists of the Ah receptor in the Antarctic fish Trematomus bernacchii: environmental perspectives
Although Antarctica is a pristine environment, organisms are challenged with contaminants either released locally or transported from industrialized regions through atmospheric circulation and marine food webs. Organisms from Terra Nova Bay also are exposed to a natural enrichment of cadmium, but to...
Published in: | Environmental Toxicology and Chemistry |
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Online Access: | http://hdl.handle.net/11566/50585 https://doi.org/10.1897/04-514R.1 |
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ftupmarcheiris:oai:iris.univpm.it:11566/50585 2024-04-14T08:04:28+00:00 Interactions between metabolism of trace metals and xenobiotic agonists of the Ah receptor in the Antarctic fish Trematomus bernacchii: environmental perspectives REGOLI, Francesco BENEDETTI, MAURA GORBI, STEFANIA FATTORINI, DANIELE NIGRO M PRETTI C GERVASI P. G Regoli, Francesco Nigro, M Benedetti, Maura Gorbi, Stefania Pretti, C Gervasi, P. G. Fattorini, Daniele 2005 http://hdl.handle.net/11566/50585 https://doi.org/10.1897/04-514R.1 eng eng info:eu-repo/semantics/altIdentifier/pmid/16117125 info:eu-repo/semantics/altIdentifier/wos/WOS:000229140400022 volume:24 issue:6 firstpage:1475 lastpage:1482 numberofpages:8 journal:ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY http://hdl.handle.net/11566/50585 doi:10.1897/04-514R.1 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-18844383969 Bioaccumulation Cytochrome P450 Interactions Oxidative stress Pollutants info:eu-repo/semantics/article 2005 ftupmarcheiris https://doi.org/10.1897/04-514R.1 2024-03-21T18:10:56Z Although Antarctica is a pristine environment, organisms are challenged with contaminants either released locally or transported from industrialized regions through atmospheric circulation and marine food webs. Organisms from Terra Nova Bay also are exposed to a natural enrichment of cadmium, but to our knowledge, whether such environmental conditions influence biological responses to anthropogenic pollutants has never been considered. In the present study, the Antarctic rock cod (Trematomus bernacchii) was exposed to model chemicals, including polycyclic aromatic hydrocarbons (benzo[a]pyrene), persistent organic pollutants (2,3,7,8-tetrachlorodibenzo-p-dioxin [TCDD]), cadmium, and a combination of cadmium and TCDD. Analyzed parameters included chemical bioaccumulation, activity, and levels of biotransformation enzymes (cytochrome P4501A); metallothioneins and the efficiency of the antioxidant system measured as individual defenses (catalase, glutathione, glutathione reductase, glutathione S-transferases, and glutathione peroxidases); and total scavenging capacity toward peroxyl and hydroxyl radicals. Reciprocal interactions between metabolism of inorganic and organic pollutants were demonstrated. Dioxin enhanced the accumulation of cadmium, probably stored within proliferating endoplasmic reticulum, and cadmium suppressed the inducibility of cytochrome P4501A, allowing us to hypothesize a posttranscriptional mechanism as the depletion of heme group availability. Clear evidence of oxidative perturbation was provided by the inhibition of antioxidants and enhanced sensitivity to oxyradical toxicity in fish exposed to organic chemicals. Exposure to cadmium revealed counteracting responses of glutathione metabolism; however, these responses did not prevent a certain loss of antioxidant capacity toward peroxyl radicals. The pattern of antioxidant responses exhibited by fish coexposed to cadmium and TCDD was more similar to that observed for cadmium than to that observed for TCDD. The overall results suggest that ... Article in Journal/Newspaper Antarc* Antarctic Antarctica Università Politecnica delle Marche: IRIS Antarctic The Antarctic Terra Nova Bay Environmental Toxicology and Chemistry 24 6 1475 |
institution |
Open Polar |
collection |
Università Politecnica delle Marche: IRIS |
op_collection_id |
ftupmarcheiris |
language |
English |
topic |
Bioaccumulation Cytochrome P450 Interactions Oxidative stress Pollutants |
spellingShingle |
Bioaccumulation Cytochrome P450 Interactions Oxidative stress Pollutants REGOLI, Francesco BENEDETTI, MAURA GORBI, STEFANIA FATTORINI, DANIELE NIGRO M PRETTI C GERVASI P. G Interactions between metabolism of trace metals and xenobiotic agonists of the Ah receptor in the Antarctic fish Trematomus bernacchii: environmental perspectives |
topic_facet |
Bioaccumulation Cytochrome P450 Interactions Oxidative stress Pollutants |
description |
Although Antarctica is a pristine environment, organisms are challenged with contaminants either released locally or transported from industrialized regions through atmospheric circulation and marine food webs. Organisms from Terra Nova Bay also are exposed to a natural enrichment of cadmium, but to our knowledge, whether such environmental conditions influence biological responses to anthropogenic pollutants has never been considered. In the present study, the Antarctic rock cod (Trematomus bernacchii) was exposed to model chemicals, including polycyclic aromatic hydrocarbons (benzo[a]pyrene), persistent organic pollutants (2,3,7,8-tetrachlorodibenzo-p-dioxin [TCDD]), cadmium, and a combination of cadmium and TCDD. Analyzed parameters included chemical bioaccumulation, activity, and levels of biotransformation enzymes (cytochrome P4501A); metallothioneins and the efficiency of the antioxidant system measured as individual defenses (catalase, glutathione, glutathione reductase, glutathione S-transferases, and glutathione peroxidases); and total scavenging capacity toward peroxyl and hydroxyl radicals. Reciprocal interactions between metabolism of inorganic and organic pollutants were demonstrated. Dioxin enhanced the accumulation of cadmium, probably stored within proliferating endoplasmic reticulum, and cadmium suppressed the inducibility of cytochrome P4501A, allowing us to hypothesize a posttranscriptional mechanism as the depletion of heme group availability. Clear evidence of oxidative perturbation was provided by the inhibition of antioxidants and enhanced sensitivity to oxyradical toxicity in fish exposed to organic chemicals. Exposure to cadmium revealed counteracting responses of glutathione metabolism; however, these responses did not prevent a certain loss of antioxidant capacity toward peroxyl radicals. The pattern of antioxidant responses exhibited by fish coexposed to cadmium and TCDD was more similar to that observed for cadmium than to that observed for TCDD. The overall results suggest that ... |
author2 |
Regoli, Francesco Nigro, M Benedetti, Maura Gorbi, Stefania Pretti, C Gervasi, P. G. Fattorini, Daniele |
format |
Article in Journal/Newspaper |
author |
REGOLI, Francesco BENEDETTI, MAURA GORBI, STEFANIA FATTORINI, DANIELE NIGRO M PRETTI C GERVASI P. G |
author_facet |
REGOLI, Francesco BENEDETTI, MAURA GORBI, STEFANIA FATTORINI, DANIELE NIGRO M PRETTI C GERVASI P. G |
author_sort |
REGOLI, Francesco |
title |
Interactions between metabolism of trace metals and xenobiotic agonists of the Ah receptor in the Antarctic fish Trematomus bernacchii: environmental perspectives |
title_short |
Interactions between metabolism of trace metals and xenobiotic agonists of the Ah receptor in the Antarctic fish Trematomus bernacchii: environmental perspectives |
title_full |
Interactions between metabolism of trace metals and xenobiotic agonists of the Ah receptor in the Antarctic fish Trematomus bernacchii: environmental perspectives |
title_fullStr |
Interactions between metabolism of trace metals and xenobiotic agonists of the Ah receptor in the Antarctic fish Trematomus bernacchii: environmental perspectives |
title_full_unstemmed |
Interactions between metabolism of trace metals and xenobiotic agonists of the Ah receptor in the Antarctic fish Trematomus bernacchii: environmental perspectives |
title_sort |
interactions between metabolism of trace metals and xenobiotic agonists of the ah receptor in the antarctic fish trematomus bernacchii: environmental perspectives |
publishDate |
2005 |
url |
http://hdl.handle.net/11566/50585 https://doi.org/10.1897/04-514R.1 |
geographic |
Antarctic The Antarctic Terra Nova Bay |
geographic_facet |
Antarctic The Antarctic Terra Nova Bay |
genre |
Antarc* Antarctic Antarctica |
genre_facet |
Antarc* Antarctic Antarctica |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/16117125 info:eu-repo/semantics/altIdentifier/wos/WOS:000229140400022 volume:24 issue:6 firstpage:1475 lastpage:1482 numberofpages:8 journal:ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY http://hdl.handle.net/11566/50585 doi:10.1897/04-514R.1 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-18844383969 |
op_doi |
https://doi.org/10.1897/04-514R.1 |
container_title |
Environmental Toxicology and Chemistry |
container_volume |
24 |
container_issue |
6 |
container_start_page |
1475 |
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1796301009568399360 |