Environmental hexachlorobenzene exposure and human male reproductive function
Hexachlorobenzene (HCB) is a persistent environmental fungicide that may disrupt androgen regulation. The aim of this study was to investigate associations between HCB levels and biomarkers of male reproductive function. 589 Spouses of pregnant women from Greenland, Poland and Ukraine were enrolled...
Published in: | Reproductive Toxicology |
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ftupmarcheiris:oai:iris.univpm.it:11566/234181 2024-04-21T08:03:26+00:00 Environmental hexachlorobenzene exposure and human male reproductive function Specht, Ina Olmer Bonde, Jens Peter Ellekilde Toft, Gunnar Giwercman, Aleksander Spanò, Marcello Manicardi, Gian Carlo Jönsson, Bo A. G. Robbins, Wendie A. BIZZARO, Davide Specht, Ina Olmer Bonde, Jens Peter Ellekilde Toft, Gunnar Giwercman, Aleksander Spanò, Marcello Bizzaro, Davide Manicardi, Gian Carlo Jönsson, Bo A. G. Robbins, Wendie A. 2015 ELETTRONICO http://hdl.handle.net/11566/234181 https://doi.org/10.1016/j.reprotox.2015.07.074 eng eng info:eu-repo/semantics/altIdentifier/pmid/26210665 info:eu-repo/semantics/altIdentifier/wos/WOS:000367559600002 volume:58 firstpage:8 lastpage:14 numberofpages:7 journal:REPRODUCTIVE TOXICOLOGY http://hdl.handle.net/11566/234181 doi:10.1016/j.reprotox.2015.07.074 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84939213235 www.elsevier.com/inca/publications/store/5/2/5/4/8/9/index.htt Antiandrogen Endocrine disrupter Fertility Hexachlorobenzene Reproduction Reproductive hormone Toxicology info:eu-repo/semantics/article 2015 ftupmarcheiris https://doi.org/10.1016/j.reprotox.2015.07.074 2024-03-28T01:41:52Z Hexachlorobenzene (HCB) is a persistent environmental fungicide that may disrupt androgen regulation. The aim of this study was to investigate associations between HCB levels and biomarkers of male reproductive function. 589 Spouses of pregnant women from Greenland, Poland and Ukraine were enrolled between 2002 and 2004. The men provided semen and blood samples and were interviewed. HCB was measured in serum by gas chromatography. The mean serum concentrations of HCB were higher in Ukraine (182.3. ng/g lipid) and Greenland (79.0. ng/g lipid) compared to Poland (14.2. ng/g lipid). Sex hormone binding globulin (SHBG) and free androgen index (FAI) were associated with HCB in men from Ukraine and Poland. This study spanning large differences in environmental HCB exposure levels shows a positive association for SHBG and negative association for FAI with high serum levels of HCB in fertile men, but without major consequences for semen quality and the Inuit study population. Article in Journal/Newspaper Greenland inuit Università Politecnica delle Marche: IRIS Reproductive Toxicology 58 8 14 |
institution |
Open Polar |
collection |
Università Politecnica delle Marche: IRIS |
op_collection_id |
ftupmarcheiris |
language |
English |
topic |
Antiandrogen Endocrine disrupter Fertility Hexachlorobenzene Reproduction Reproductive hormone Toxicology |
spellingShingle |
Antiandrogen Endocrine disrupter Fertility Hexachlorobenzene Reproduction Reproductive hormone Toxicology Specht, Ina Olmer Bonde, Jens Peter Ellekilde Toft, Gunnar Giwercman, Aleksander Spanò, Marcello Manicardi, Gian Carlo Jönsson, Bo A. G. Robbins, Wendie A. BIZZARO, Davide Environmental hexachlorobenzene exposure and human male reproductive function |
topic_facet |
Antiandrogen Endocrine disrupter Fertility Hexachlorobenzene Reproduction Reproductive hormone Toxicology |
description |
Hexachlorobenzene (HCB) is a persistent environmental fungicide that may disrupt androgen regulation. The aim of this study was to investigate associations between HCB levels and biomarkers of male reproductive function. 589 Spouses of pregnant women from Greenland, Poland and Ukraine were enrolled between 2002 and 2004. The men provided semen and blood samples and were interviewed. HCB was measured in serum by gas chromatography. The mean serum concentrations of HCB were higher in Ukraine (182.3. ng/g lipid) and Greenland (79.0. ng/g lipid) compared to Poland (14.2. ng/g lipid). Sex hormone binding globulin (SHBG) and free androgen index (FAI) were associated with HCB in men from Ukraine and Poland. This study spanning large differences in environmental HCB exposure levels shows a positive association for SHBG and negative association for FAI with high serum levels of HCB in fertile men, but without major consequences for semen quality and the Inuit study population. |
author2 |
Specht, Ina Olmer Bonde, Jens Peter Ellekilde Toft, Gunnar Giwercman, Aleksander Spanò, Marcello Bizzaro, Davide Manicardi, Gian Carlo Jönsson, Bo A. G. Robbins, Wendie A. |
format |
Article in Journal/Newspaper |
author |
Specht, Ina Olmer Bonde, Jens Peter Ellekilde Toft, Gunnar Giwercman, Aleksander Spanò, Marcello Manicardi, Gian Carlo Jönsson, Bo A. G. Robbins, Wendie A. BIZZARO, Davide |
author_facet |
Specht, Ina Olmer Bonde, Jens Peter Ellekilde Toft, Gunnar Giwercman, Aleksander Spanò, Marcello Manicardi, Gian Carlo Jönsson, Bo A. G. Robbins, Wendie A. BIZZARO, Davide |
author_sort |
Specht, Ina Olmer |
title |
Environmental hexachlorobenzene exposure and human male reproductive function |
title_short |
Environmental hexachlorobenzene exposure and human male reproductive function |
title_full |
Environmental hexachlorobenzene exposure and human male reproductive function |
title_fullStr |
Environmental hexachlorobenzene exposure and human male reproductive function |
title_full_unstemmed |
Environmental hexachlorobenzene exposure and human male reproductive function |
title_sort |
environmental hexachlorobenzene exposure and human male reproductive function |
publishDate |
2015 |
url |
http://hdl.handle.net/11566/234181 https://doi.org/10.1016/j.reprotox.2015.07.074 |
genre |
Greenland inuit |
genre_facet |
Greenland inuit |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/26210665 info:eu-repo/semantics/altIdentifier/wos/WOS:000367559600002 volume:58 firstpage:8 lastpage:14 numberofpages:7 journal:REPRODUCTIVE TOXICOLOGY http://hdl.handle.net/11566/234181 doi:10.1016/j.reprotox.2015.07.074 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84939213235 www.elsevier.com/inca/publications/store/5/2/5/4/8/9/index.htt |
op_doi |
https://doi.org/10.1016/j.reprotox.2015.07.074 |
container_title |
Reproductive Toxicology |
container_volume |
58 |
container_start_page |
8 |
op_container_end_page |
14 |
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1796943280270737408 |