Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine

Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of envi...

Full description

Bibliographic Details
Published in:Reproductive Toxicology
Main Authors: Toft, Gunnar, Lenters, Virissa, Vermeulen, Roel, Heederik, Dick, Thomsen, Cathrine, Becher, Georg, Giwercman, Aleksander, Manicardi, Gian Carlo, Spanò, Marcello, Rylander, Lars, Pedersen, Henning S., Struciński, Paweł, Zviezdai, Valentyna, Bonde, Jens Peter, BIZZARO, Davide
Other Authors: Bizzaro, Davide, Rylander, Lar
Format: Article in Journal/Newspaper
Language:English
Published: 2014
Subjects:
Apoptosi
BDE-153
BDE-47
DNA damage
Inhibin B
PBDE
Reproductive hormone
Semen quality
Adult
Environmental Monitoring
Environmental Pollutant
Estradiol
Flame Retardant
Follicle Stimulating Hormone
Greenland
Halogenated Diphenyl Ether
Human
In Situ Nick-End Labeling
Luteinizing Hormone
Male
Poland
Polybrominated Biphenyl
Sperm Count
Sperm Motility
Testosterone
Ukraine
Young Adult
Toxicology
Arctic
Online Access:http://hdl.handle.net/11566/229128
https://doi.org/10.1016/j.reprotox.2013.10.002
Description
Summary:Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations.

Similar Items