New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes
Electrospun scaffolds from an amino acid containing poly(ester urea) (PEU) were developed as promising materials in the biomedical field and specifically in tissue engineering applications. The selected poly(ester urea) was obtained with a high yield and molecular weight by reaction of phosgene with...
Published in: | Materials Science and Engineering: C |
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Online Access: | http://hdl.handle.net/2117/103928 https://doi.org/10.1016/j.msec.2014.10.055 |
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ftupcatalunyair:oai:upcommons.upc.edu:2117/103928 2024-09-15T18:01:41+00:00 New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes Díaz Andrade, Angélica María Valle Mendoza, Luis Javier del Tugushi, David Katsarava, Ramaz Puiggalí Bellalta, Jordi Universitat Politècnica de Catalunya. Departament d'Enginyeria Química Universitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables 2015-01-01 13 p. application/pdf http://hdl.handle.net/2117/103928 https://doi.org/10.1016/j.msec.2014.10.055 eng eng Elsevier http://www.sciencedirect.com/science/article/pii/S0928493114006754 info:eu-repo/grantAgreement/MINECO/1PE/MAT2012-36205 Diaz, A., del Valle, LJ., Tugushi, D., Katsarava, R., Puiggali, J. New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes. "Materials science and engineering C. Biomimetic and supramolecular systems", 1 Gener 2015, vol. 46, p. 450-462. 0928-4931 http://hdl.handle.net/2117/103928 doi:10.1016/j.msec.2014.10.055 Attribution-NonCommercial-NoDerivs 3.0 Spain http://creativecommons.org/licenses/by-nc-nd/3.0/es/ Open Access Àrees temàtiques de la UPC::Enginyeria química Polyesters Polymers--Biodegradation Poly(ester urea) L-Leucine Electrospinning Scaffold Enzymatic degradation Biocompatibility Biguanide Drug release alpha omega-alkylene diesters polyhexamethylene biguanide polymer nanofibers cellulose-acetate chlorhexidine polylactide release fibers surfaces degradation Polímers -- Biocompatibilitat Polièsters Article 2015 ftupcatalunyair https://doi.org/10.1016/j.msec.2014.10.055 2024-07-25T11:16:42Z Electrospun scaffolds from an amino acid containing poly(ester urea) (PEU) were developed as promising materials in the biomedical field and specifically in tissue engineering applications. The selected poly(ester urea) was obtained with a high yield and molecular weight by reaction of phosgene with a bis(alpha-aminoacy1)-alpha,omega-dioldiester monomer. The polymer having L-Ieucine, 1,6-hexanediol and carbonic acid units had a semicrystalline character and relatively high glass transition and melting temperatures. Furthermore it was highly soluble in most organic solvents, an interesting feature that facilitated the electrospinning process and the effective incorporation of drugs with bactericidal activity (e.g. biguanide derivatives such as clorhexidine and polyhexamethylenebiguanide) and enzymes (e.g. alpha-chymotrypsin) that accelerated the degradation process. Continuous micro/nanofibers were obtained under a wide range of processing conditions, being diameters of electrospun fibers dependent on the drug and solvent used.; Poly(ester urea) samples were degradable in media containing lipases and proteinases but the degradation rate was highly dependent on the surface area, being specifically greater for scaffolds with respect to films. The high hydrophobicity of new scaffolds had repercussions on enzymatic degradability since different weight loss rates were found depending on how samples were exposed to the medium (e.g. forced or non-forced immersion). New scaffolds were biocompatible, as demonstrated by adhesion and proliferation assays performed with fibroblast and epithelial cells. (C) 2014 Elsevier B.V. All rights reserved. Peer Reviewed Postprint (published version) Article in Journal/Newspaper Carbonic acid Universitat Politècnica de Catalunya, BarcelonaTech: UPCommons - Global access to UPC knowledge Materials Science and Engineering: C 46 450 462 |
institution |
Open Polar |
collection |
Universitat Politècnica de Catalunya, BarcelonaTech: UPCommons - Global access to UPC knowledge |
op_collection_id |
ftupcatalunyair |
language |
English |
topic |
Àrees temàtiques de la UPC::Enginyeria química Polyesters Polymers--Biodegradation Poly(ester urea) L-Leucine Electrospinning Scaffold Enzymatic degradation Biocompatibility Biguanide Drug release alpha omega-alkylene diesters polyhexamethylene biguanide polymer nanofibers cellulose-acetate chlorhexidine polylactide release fibers surfaces degradation Polímers -- Biocompatibilitat Polièsters |
spellingShingle |
Àrees temàtiques de la UPC::Enginyeria química Polyesters Polymers--Biodegradation Poly(ester urea) L-Leucine Electrospinning Scaffold Enzymatic degradation Biocompatibility Biguanide Drug release alpha omega-alkylene diesters polyhexamethylene biguanide polymer nanofibers cellulose-acetate chlorhexidine polylactide release fibers surfaces degradation Polímers -- Biocompatibilitat Polièsters Díaz Andrade, Angélica María Valle Mendoza, Luis Javier del Tugushi, David Katsarava, Ramaz Puiggalí Bellalta, Jordi New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes |
topic_facet |
Àrees temàtiques de la UPC::Enginyeria química Polyesters Polymers--Biodegradation Poly(ester urea) L-Leucine Electrospinning Scaffold Enzymatic degradation Biocompatibility Biguanide Drug release alpha omega-alkylene diesters polyhexamethylene biguanide polymer nanofibers cellulose-acetate chlorhexidine polylactide release fibers surfaces degradation Polímers -- Biocompatibilitat Polièsters |
description |
Electrospun scaffolds from an amino acid containing poly(ester urea) (PEU) were developed as promising materials in the biomedical field and specifically in tissue engineering applications. The selected poly(ester urea) was obtained with a high yield and molecular weight by reaction of phosgene with a bis(alpha-aminoacy1)-alpha,omega-dioldiester monomer. The polymer having L-Ieucine, 1,6-hexanediol and carbonic acid units had a semicrystalline character and relatively high glass transition and melting temperatures. Furthermore it was highly soluble in most organic solvents, an interesting feature that facilitated the electrospinning process and the effective incorporation of drugs with bactericidal activity (e.g. biguanide derivatives such as clorhexidine and polyhexamethylenebiguanide) and enzymes (e.g. alpha-chymotrypsin) that accelerated the degradation process. Continuous micro/nanofibers were obtained under a wide range of processing conditions, being diameters of electrospun fibers dependent on the drug and solvent used.; Poly(ester urea) samples were degradable in media containing lipases and proteinases but the degradation rate was highly dependent on the surface area, being specifically greater for scaffolds with respect to films. The high hydrophobicity of new scaffolds had repercussions on enzymatic degradability since different weight loss rates were found depending on how samples were exposed to the medium (e.g. forced or non-forced immersion). New scaffolds were biocompatible, as demonstrated by adhesion and proliferation assays performed with fibroblast and epithelial cells. (C) 2014 Elsevier B.V. All rights reserved. Peer Reviewed Postprint (published version) |
author2 |
Universitat Politècnica de Catalunya. Departament d'Enginyeria Química Universitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables |
format |
Article in Journal/Newspaper |
author |
Díaz Andrade, Angélica María Valle Mendoza, Luis Javier del Tugushi, David Katsarava, Ramaz Puiggalí Bellalta, Jordi |
author_facet |
Díaz Andrade, Angélica María Valle Mendoza, Luis Javier del Tugushi, David Katsarava, Ramaz Puiggalí Bellalta, Jordi |
author_sort |
Díaz Andrade, Angélica María |
title |
New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes |
title_short |
New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes |
title_full |
New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes |
title_fullStr |
New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes |
title_full_unstemmed |
New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes |
title_sort |
new poly(ester urea) derived from l-leucine: electrospun scaffolds loaded with antibacterial drugs and enzymes |
publisher |
Elsevier |
publishDate |
2015 |
url |
http://hdl.handle.net/2117/103928 https://doi.org/10.1016/j.msec.2014.10.055 |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_relation |
http://www.sciencedirect.com/science/article/pii/S0928493114006754 info:eu-repo/grantAgreement/MINECO/1PE/MAT2012-36205 Diaz, A., del Valle, LJ., Tugushi, D., Katsarava, R., Puiggali, J. New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes. "Materials science and engineering C. Biomimetic and supramolecular systems", 1 Gener 2015, vol. 46, p. 450-462. 0928-4931 http://hdl.handle.net/2117/103928 doi:10.1016/j.msec.2014.10.055 |
op_rights |
Attribution-NonCommercial-NoDerivs 3.0 Spain http://creativecommons.org/licenses/by-nc-nd/3.0/es/ Open Access |
op_doi |
https://doi.org/10.1016/j.msec.2014.10.055 |
container_title |
Materials Science and Engineering: C |
container_volume |
46 |
container_start_page |
450 |
op_container_end_page |
462 |
_version_ |
1810438774520283136 |