Genomic dissection of an Icelandic epidemic of respiratory disease in horses and associated zoonotic cases
Iceland is free of the major infectious diseases of horses. However, in 2010 an epidemic of respiratory disease of unknown cause spread through the country's native horse population of 77,000. Microbiological investigations ruled out known viral agents but identified the opportunistic pathogen...
Published in: | mBio |
---|---|
Main Authors: | , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2017
|
Subjects: | |
Online Access: | https://risweb.st-andrews.ac.uk/portal/en/researchoutput/genomic-dissection-of-an-icelandic-epidemic-of-respiratory-disease-in-horses-and-associated-zoonotic-cases(e54e0fee-a83b-4306-8638-88876c0413fe).html https://doi.org/10.1128/mBio.00826-17 https://research-repository.st-andrews.ac.uk/bitstream/10023/11396/1/Holden_2017_mBio_GenomicDissection_CC.pdf |
id |
ftunstandrewcris:oai:risweb.st-andrews.ac.uk:publications/e54e0fee-a83b-4306-8638-88876c0413fe |
---|---|
record_format |
openpolar |
spelling |
ftunstandrewcris:oai:risweb.st-andrews.ac.uk:publications/e54e0fee-a83b-4306-8638-88876c0413fe 2023-05-15T16:48:10+02:00 Genomic dissection of an Icelandic epidemic of respiratory disease in horses and associated zoonotic cases Björnsdóttir, Sigríður Harris, Simon R. Svansson, Vilhjálmur Gunnarsson, Eggert Sigurðardóttir, Ólöf G. Gammeljord, Kristina Steward, Karen F. Newton, J. Richard Robinson, Carl Charbonneau, Amelia R. L. Parkhill, Julian Holden, Matthew T. G. Waller, Andrew S. 2017-08-01 application/pdf https://risweb.st-andrews.ac.uk/portal/en/researchoutput/genomic-dissection-of-an-icelandic-epidemic-of-respiratory-disease-in-horses-and-associated-zoonotic-cases(e54e0fee-a83b-4306-8638-88876c0413fe).html https://doi.org/10.1128/mBio.00826-17 https://research-repository.st-andrews.ac.uk/bitstream/10023/11396/1/Holden_2017_mBio_GenomicDissection_CC.pdf eng eng info:eu-repo/semantics/openAccess Björnsdóttir , S , Harris , S R , Svansson , V , Gunnarsson , E , Sigurðardóttir , Ó G , Gammeljord , K , Steward , K F , Newton , J R , Robinson , C , Charbonneau , A R L , Parkhill , J , Holden , M T G & Waller , A S 2017 , ' Genomic dissection of an Icelandic epidemic of respiratory disease in horses and associated zoonotic cases ' , mBio , vol. 8 , no. 4 , e00826-17 . https://doi.org/10.1128/mBio.00826-17 Icelandic horse Streptococcus zooepedemicus Epidemiology Genome analysis Respiratory pathogens Zoonotic infections article 2017 ftunstandrewcris https://doi.org/10.1128/mBio.00826-17 2022-06-02T07:47:43Z Iceland is free of the major infectious diseases of horses. However, in 2010 an epidemic of respiratory disease of unknown cause spread through the country's native horse population of 77,000. Microbiological investigations ruled out known viral agents but identified the opportunistic pathogen Streptococcus equi subsp. zooepidemicus ( S. zooepidemicus ) in diseased animals. We sequenced the genomes of 257 isolates of S. zooepidemicus to differentiate epidemic from endemic strains. We found that although multiple endemic clones of S. zooepidemicus were present, one particular clone, sequence type 209 (ST209), was likely to have been responsible for the epidemic. Concurrent with the epidemic, ST209 was also recovered from a human case of septicemia, highlighting the pathogenic potential of this strain. Epidemiological investigation revealed that the incursion of this strain into one training yard during February 2010 provided a nidus for the infection of multiple horses that then transmitted the strain to farms throughout Iceland. This study represents the first time that whole-genome sequencing has been used to investigate an epidemic on a national scale to identify the likely causative agent and the link to an associated zoonotic infection. Our data highlight the importance of national biosecurity to protect vulnerable populations of animals and also demonstrate the potential impact of S. zooepidemicus transmission to other animals, including humans. Article in Journal/Newspaper Iceland University of St Andrews: Research Portal mBio 8 4 |
institution |
Open Polar |
collection |
University of St Andrews: Research Portal |
op_collection_id |
ftunstandrewcris |
language |
English |
topic |
Icelandic horse Streptococcus zooepedemicus Epidemiology Genome analysis Respiratory pathogens Zoonotic infections |
spellingShingle |
Icelandic horse Streptococcus zooepedemicus Epidemiology Genome analysis Respiratory pathogens Zoonotic infections Björnsdóttir, Sigríður Harris, Simon R. Svansson, Vilhjálmur Gunnarsson, Eggert Sigurðardóttir, Ólöf G. Gammeljord, Kristina Steward, Karen F. Newton, J. Richard Robinson, Carl Charbonneau, Amelia R. L. Parkhill, Julian Holden, Matthew T. G. Waller, Andrew S. Genomic dissection of an Icelandic epidemic of respiratory disease in horses and associated zoonotic cases |
topic_facet |
Icelandic horse Streptococcus zooepedemicus Epidemiology Genome analysis Respiratory pathogens Zoonotic infections |
description |
Iceland is free of the major infectious diseases of horses. However, in 2010 an epidemic of respiratory disease of unknown cause spread through the country's native horse population of 77,000. Microbiological investigations ruled out known viral agents but identified the opportunistic pathogen Streptococcus equi subsp. zooepidemicus ( S. zooepidemicus ) in diseased animals. We sequenced the genomes of 257 isolates of S. zooepidemicus to differentiate epidemic from endemic strains. We found that although multiple endemic clones of S. zooepidemicus were present, one particular clone, sequence type 209 (ST209), was likely to have been responsible for the epidemic. Concurrent with the epidemic, ST209 was also recovered from a human case of septicemia, highlighting the pathogenic potential of this strain. Epidemiological investigation revealed that the incursion of this strain into one training yard during February 2010 provided a nidus for the infection of multiple horses that then transmitted the strain to farms throughout Iceland. This study represents the first time that whole-genome sequencing has been used to investigate an epidemic on a national scale to identify the likely causative agent and the link to an associated zoonotic infection. Our data highlight the importance of national biosecurity to protect vulnerable populations of animals and also demonstrate the potential impact of S. zooepidemicus transmission to other animals, including humans. |
format |
Article in Journal/Newspaper |
author |
Björnsdóttir, Sigríður Harris, Simon R. Svansson, Vilhjálmur Gunnarsson, Eggert Sigurðardóttir, Ólöf G. Gammeljord, Kristina Steward, Karen F. Newton, J. Richard Robinson, Carl Charbonneau, Amelia R. L. Parkhill, Julian Holden, Matthew T. G. Waller, Andrew S. |
author_facet |
Björnsdóttir, Sigríður Harris, Simon R. Svansson, Vilhjálmur Gunnarsson, Eggert Sigurðardóttir, Ólöf G. Gammeljord, Kristina Steward, Karen F. Newton, J. Richard Robinson, Carl Charbonneau, Amelia R. L. Parkhill, Julian Holden, Matthew T. G. Waller, Andrew S. |
author_sort |
Björnsdóttir, Sigríður |
title |
Genomic dissection of an Icelandic epidemic of respiratory disease in horses and associated zoonotic cases |
title_short |
Genomic dissection of an Icelandic epidemic of respiratory disease in horses and associated zoonotic cases |
title_full |
Genomic dissection of an Icelandic epidemic of respiratory disease in horses and associated zoonotic cases |
title_fullStr |
Genomic dissection of an Icelandic epidemic of respiratory disease in horses and associated zoonotic cases |
title_full_unstemmed |
Genomic dissection of an Icelandic epidemic of respiratory disease in horses and associated zoonotic cases |
title_sort |
genomic dissection of an icelandic epidemic of respiratory disease in horses and associated zoonotic cases |
publishDate |
2017 |
url |
https://risweb.st-andrews.ac.uk/portal/en/researchoutput/genomic-dissection-of-an-icelandic-epidemic-of-respiratory-disease-in-horses-and-associated-zoonotic-cases(e54e0fee-a83b-4306-8638-88876c0413fe).html https://doi.org/10.1128/mBio.00826-17 https://research-repository.st-andrews.ac.uk/bitstream/10023/11396/1/Holden_2017_mBio_GenomicDissection_CC.pdf |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Björnsdóttir , S , Harris , S R , Svansson , V , Gunnarsson , E , Sigurðardóttir , Ó G , Gammeljord , K , Steward , K F , Newton , J R , Robinson , C , Charbonneau , A R L , Parkhill , J , Holden , M T G & Waller , A S 2017 , ' Genomic dissection of an Icelandic epidemic of respiratory disease in horses and associated zoonotic cases ' , mBio , vol. 8 , no. 4 , e00826-17 . https://doi.org/10.1128/mBio.00826-17 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1128/mBio.00826-17 |
container_title |
mBio |
container_volume |
8 |
container_issue |
4 |
_version_ |
1766038277483134976 |