A Cationic Ruthenium Complex for the Dynamic Kinetic Resolution of Secondary Alcohols
A synthetic protocol making use of a well-defined cationic ruthenium complex 2 enabling the racemization of enantiomerically pure secondary alcohols in the presence of a weak base (K2CO3) is described. The compatibility of 2 with Candida Antarctica lipase B (Novozym 435) allows the development of an...
| Published in: | Chemistry - A European Journal |
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| Main Authors: | , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://risweb.st-andrews.ac.uk/portal/en/researchoutput/a-cationic-ruthenium-complex-for-the-dynamic-kinetic-resolution-of-secondary-alcohols(4234f443-6449-463a-bc38-77b89db13dc6).html https://doi.org/10.1002/chem.201404096 |
| Summary: | A synthetic protocol making use of a well-defined cationic ruthenium complex 2 enabling the racemization of enantiomerically pure secondary alcohols in the presence of a weak base (K2CO3) is described. The compatibility of 2 with Candida Antarctica lipase B (Novozym 435) allows the development of an efficient dynamic kinetic resolution of sec-alcohols in the absence of an additional strong base. This procedure involves the first example of a dynamic kinetic resolution of alcohols in the presence of a cationic ruthenium catalyst. In addition, we describe the conversion of ketones to the enantio enriched acetates in a one-pot reaction, probing the versatility of complex 2. |
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