A Cationic Ruthenium Complex for the Dynamic Kinetic Resolution of Secondary Alcohols
A synthetic protocol making use of a well-defined cationic ruthenium complex 2 enabling the racemization of enantiomerically pure secondary alcohols in the presence of a weak base (K2CO3) is described. The compatibility of 2 with Candida Antarctica lipase B (Novozym 435) allows the development of an...
Published in: | Chemistry – A European Journal |
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2014
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ftunstandrewcris:oai:research-portal.st-andrews.ac.uk:publications/4234f443-6449-463a-bc38-77b89db13dc6 2024-06-23T07:47:57+00:00 A Cationic Ruthenium Complex for the Dynamic Kinetic Resolution of Secondary Alcohols Fernandez Salas, Jose Antonio Manzini, Simone Nolan, Steven Patrick 2014 https://research-portal.st-andrews.ac.uk/en/researchoutput/a-cationic-ruthenium-complex-for-the-dynamic-kinetic-resolution-of-secondary-alcohols(4234f443-6449-463a-bc38-77b89db13dc6).html https://doi.org/10.1002/chem.201404096 eng eng https://research-portal.st-andrews.ac.uk/en/researchoutput/a-cationic-ruthenium-complex-for-the-dynamic-kinetic-resolution-of-secondary-alcohols(4234f443-6449-463a-bc38-77b89db13dc6).html info:eu-repo/semantics/restrictedAccess Fernandez Salas , J A , Manzini , S & Nolan , S P 2014 , ' A Cationic Ruthenium Complex for the Dynamic Kinetic Resolution of Secondary Alcohols ' , Chemistry - A European Journal , vol. 20 , pp. 13132-13135 . https://doi.org/10.1002/chem.201404096 article 2014 ftunstandrewcris https://doi.org/10.1002/chem.201404096 2024-06-13T00:44:41Z A synthetic protocol making use of a well-defined cationic ruthenium complex 2 enabling the racemization of enantiomerically pure secondary alcohols in the presence of a weak base (K2CO3) is described. The compatibility of 2 with Candida Antarctica lipase B (Novozym 435) allows the development of an efficient dynamic kinetic resolution of sec-alcohols in the absence of an additional strong base. This procedure involves the first example of a dynamic kinetic resolution of alcohols in the presence of a cationic ruthenium catalyst. In addition, we describe the conversion of ketones to the enantio enriched acetates in a one-pot reaction, probing the versatility of complex 2. Article in Journal/Newspaper Antarc* Antarctica University of St Andrews: Research Portal Chemistry – A European Journal 20 41 13132 13135 |
institution |
Open Polar |
collection |
University of St Andrews: Research Portal |
op_collection_id |
ftunstandrewcris |
language |
English |
description |
A synthetic protocol making use of a well-defined cationic ruthenium complex 2 enabling the racemization of enantiomerically pure secondary alcohols in the presence of a weak base (K2CO3) is described. The compatibility of 2 with Candida Antarctica lipase B (Novozym 435) allows the development of an efficient dynamic kinetic resolution of sec-alcohols in the absence of an additional strong base. This procedure involves the first example of a dynamic kinetic resolution of alcohols in the presence of a cationic ruthenium catalyst. In addition, we describe the conversion of ketones to the enantio enriched acetates in a one-pot reaction, probing the versatility of complex 2. |
format |
Article in Journal/Newspaper |
author |
Fernandez Salas, Jose Antonio Manzini, Simone Nolan, Steven Patrick |
spellingShingle |
Fernandez Salas, Jose Antonio Manzini, Simone Nolan, Steven Patrick A Cationic Ruthenium Complex for the Dynamic Kinetic Resolution of Secondary Alcohols |
author_facet |
Fernandez Salas, Jose Antonio Manzini, Simone Nolan, Steven Patrick |
author_sort |
Fernandez Salas, Jose Antonio |
title |
A Cationic Ruthenium Complex for the Dynamic Kinetic Resolution of Secondary Alcohols |
title_short |
A Cationic Ruthenium Complex for the Dynamic Kinetic Resolution of Secondary Alcohols |
title_full |
A Cationic Ruthenium Complex for the Dynamic Kinetic Resolution of Secondary Alcohols |
title_fullStr |
A Cationic Ruthenium Complex for the Dynamic Kinetic Resolution of Secondary Alcohols |
title_full_unstemmed |
A Cationic Ruthenium Complex for the Dynamic Kinetic Resolution of Secondary Alcohols |
title_sort |
cationic ruthenium complex for the dynamic kinetic resolution of secondary alcohols |
publishDate |
2014 |
url |
https://research-portal.st-andrews.ac.uk/en/researchoutput/a-cationic-ruthenium-complex-for-the-dynamic-kinetic-resolution-of-secondary-alcohols(4234f443-6449-463a-bc38-77b89db13dc6).html https://doi.org/10.1002/chem.201404096 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Fernandez Salas , J A , Manzini , S & Nolan , S P 2014 , ' A Cationic Ruthenium Complex for the Dynamic Kinetic Resolution of Secondary Alcohols ' , Chemistry - A European Journal , vol. 20 , pp. 13132-13135 . https://doi.org/10.1002/chem.201404096 |
op_relation |
https://research-portal.st-andrews.ac.uk/en/researchoutput/a-cationic-ruthenium-complex-for-the-dynamic-kinetic-resolution-of-secondary-alcohols(4234f443-6449-463a-bc38-77b89db13dc6).html |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1002/chem.201404096 |
container_title |
Chemistry – A European Journal |
container_volume |
20 |
container_issue |
41 |
container_start_page |
13132 |
op_container_end_page |
13135 |
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1802638261702623232 |