Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002
The 1988 and 2002 phocine distemper virus (PDV) outbreaks in European harbour seals Phoca vitulina are among the largest mass mortality events recorded in marine mammals. Despite its large impact on harbour seal population numbers, and 3 decades of studies, many questions regarding the spread and te...
Published in: | Diseases of Aquatic Organisms |
---|---|
Main Authors: | , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2019
|
Subjects: | |
Online Access: | https://research-portal.st-andrews.ac.uk/en/researchoutput/phylogenomic-insights-to-the-origin-and-spread-of-phocine-distemper-virus-in-european-harbour-seals-in-1988-and-2002(3e3fa66c-0d9e-4030-8890-1ea8da781c5c).html https://doi.org/10.3354/dao03328 https://research-repository.st-andrews.ac.uk/bitstream/10023/19511/1/DAO_Accepted_Manuscript.pdf |
id |
ftunstandrewcris:oai:research-portal.st-andrews.ac.uk:publications/3e3fa66c-0d9e-4030-8890-1ea8da781c5c |
---|---|
record_format |
openpolar |
spelling |
ftunstandrewcris:oai:research-portal.st-andrews.ac.uk:publications/3e3fa66c-0d9e-4030-8890-1ea8da781c5c 2024-09-15T18:10:46+00:00 Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002 Stokholm, Iben Härkönen, Tero Harding, Karin C. Siebert, Ursula Lehnert, Kristina Dietz, Rune Teilmann, Jonas Galatius, Anders Havmøller, Linnea Worsøe Carroll, Emma L. Hall, Ailsa Olsen, Morten Tange 2019-02-21 application/pdf https://research-portal.st-andrews.ac.uk/en/researchoutput/phylogenomic-insights-to-the-origin-and-spread-of-phocine-distemper-virus-in-european-harbour-seals-in-1988-and-2002(3e3fa66c-0d9e-4030-8890-1ea8da781c5c).html https://doi.org/10.3354/dao03328 https://research-repository.st-andrews.ac.uk/bitstream/10023/19511/1/DAO_Accepted_Manuscript.pdf eng eng https://research-portal.st-andrews.ac.uk/en/researchoutput/phylogenomic-insights-to-the-origin-and-spread-of-phocine-distemper-virus-in-european-harbour-seals-in-1988-and-2002(3e3fa66c-0d9e-4030-8890-1ea8da781c5c).html info:eu-repo/semantics/openAccess Stokholm , I , Härkönen , T , Harding , K C , Siebert , U , Lehnert , K , Dietz , R , Teilmann , J , Galatius , A , Havmøller , L W , Carroll , E L , Hall , A & Olsen , M T 2019 , ' Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002 ' , Diseases of Aquatic Organisms , vol. 133 , no. 1 , pp. 47-56 . https://doi.org/10.3354/dao03328 Epidemic Morbillivirus Viral phylogeny Virus evolution Wildlife pathogen article 2019 ftunstandrewcris https://doi.org/10.3354/dao03328 2024-08-21T23:46:11Z The 1988 and 2002 phocine distemper virus (PDV) outbreaks in European harbour seals Phoca vitulina are among the largest mass mortality events recorded in marine mammals. Despite its large impact on harbour seal population numbers, and 3 decades of studies, many questions regarding the spread and temporal origin of PDV remain unanswered. Here, we sequenced and analysed 7123 bp of the PDV genome, including the coding and non-coding regions of the entire P, M, F and H genes in tissues from 44 harbour seals to shed new light on the origin and spread of PDV in 1988 and 2002. The phylogenetic analyses trace the origin of the PDV strain causing the 1988 outbreak to between June 1987 and April 1988, while the origin of the strain causing the 2002 outbreak can be traced back to between July 2001 and April 2002. The analyses further point to several independent introductions of PDV in 1988, possibly linked to a southward mass immigration of harp seals in the winter and spring of 1987−1988. The vector for the 2002 outbreak is unknown, but the epidemiological analyses suggest the subsequent spread of PDV from the epicentre in the Kattegat, Denmark, to haul-out sites in the North Sea through several independent introductions. Article in Journal/Newspaper harbour seal Phoca vitulina University of St Andrews: Research Portal Diseases of Aquatic Organisms 133 1 47 56 |
institution |
Open Polar |
collection |
University of St Andrews: Research Portal |
op_collection_id |
ftunstandrewcris |
language |
English |
topic |
Epidemic Morbillivirus Viral phylogeny Virus evolution Wildlife pathogen |
spellingShingle |
Epidemic Morbillivirus Viral phylogeny Virus evolution Wildlife pathogen Stokholm, Iben Härkönen, Tero Harding, Karin C. Siebert, Ursula Lehnert, Kristina Dietz, Rune Teilmann, Jonas Galatius, Anders Havmøller, Linnea Worsøe Carroll, Emma L. Hall, Ailsa Olsen, Morten Tange Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002 |
topic_facet |
Epidemic Morbillivirus Viral phylogeny Virus evolution Wildlife pathogen |
description |
The 1988 and 2002 phocine distemper virus (PDV) outbreaks in European harbour seals Phoca vitulina are among the largest mass mortality events recorded in marine mammals. Despite its large impact on harbour seal population numbers, and 3 decades of studies, many questions regarding the spread and temporal origin of PDV remain unanswered. Here, we sequenced and analysed 7123 bp of the PDV genome, including the coding and non-coding regions of the entire P, M, F and H genes in tissues from 44 harbour seals to shed new light on the origin and spread of PDV in 1988 and 2002. The phylogenetic analyses trace the origin of the PDV strain causing the 1988 outbreak to between June 1987 and April 1988, while the origin of the strain causing the 2002 outbreak can be traced back to between July 2001 and April 2002. The analyses further point to several independent introductions of PDV in 1988, possibly linked to a southward mass immigration of harp seals in the winter and spring of 1987−1988. The vector for the 2002 outbreak is unknown, but the epidemiological analyses suggest the subsequent spread of PDV from the epicentre in the Kattegat, Denmark, to haul-out sites in the North Sea through several independent introductions. |
format |
Article in Journal/Newspaper |
author |
Stokholm, Iben Härkönen, Tero Harding, Karin C. Siebert, Ursula Lehnert, Kristina Dietz, Rune Teilmann, Jonas Galatius, Anders Havmøller, Linnea Worsøe Carroll, Emma L. Hall, Ailsa Olsen, Morten Tange |
author_facet |
Stokholm, Iben Härkönen, Tero Harding, Karin C. Siebert, Ursula Lehnert, Kristina Dietz, Rune Teilmann, Jonas Galatius, Anders Havmøller, Linnea Worsøe Carroll, Emma L. Hall, Ailsa Olsen, Morten Tange |
author_sort |
Stokholm, Iben |
title |
Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002 |
title_short |
Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002 |
title_full |
Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002 |
title_fullStr |
Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002 |
title_full_unstemmed |
Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002 |
title_sort |
phylogenomic insights to the origin and spread of phocine distemper virus in european harbour seals in 1988 and 2002 |
publishDate |
2019 |
url |
https://research-portal.st-andrews.ac.uk/en/researchoutput/phylogenomic-insights-to-the-origin-and-spread-of-phocine-distemper-virus-in-european-harbour-seals-in-1988-and-2002(3e3fa66c-0d9e-4030-8890-1ea8da781c5c).html https://doi.org/10.3354/dao03328 https://research-repository.st-andrews.ac.uk/bitstream/10023/19511/1/DAO_Accepted_Manuscript.pdf |
genre |
harbour seal Phoca vitulina |
genre_facet |
harbour seal Phoca vitulina |
op_source |
Stokholm , I , Härkönen , T , Harding , K C , Siebert , U , Lehnert , K , Dietz , R , Teilmann , J , Galatius , A , Havmøller , L W , Carroll , E L , Hall , A & Olsen , M T 2019 , ' Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002 ' , Diseases of Aquatic Organisms , vol. 133 , no. 1 , pp. 47-56 . https://doi.org/10.3354/dao03328 |
op_relation |
https://research-portal.st-andrews.ac.uk/en/researchoutput/phylogenomic-insights-to-the-origin-and-spread-of-phocine-distemper-virus-in-european-harbour-seals-in-1988-and-2002(3e3fa66c-0d9e-4030-8890-1ea8da781c5c).html |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3354/dao03328 |
container_title |
Diseases of Aquatic Organisms |
container_volume |
133 |
container_issue |
1 |
container_start_page |
47 |
op_container_end_page |
56 |
_version_ |
1810448342641016832 |