The risk of infection from polychlorinated biphenyl exposure in harbor porpoise ( Phocoena phocoena ) - A case-control approach

• Published in: Environmental Health Perspectives
• Main Authors: Hall, Ailsa Jane, Hugunin, K, Deaville, R, Law, R, Allchin, C R, Jepson, P D
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2006
• Subjects: cetaceans; dose response; immunosuppression; PCBs; risk assessment; SEALS PHOCA-VITULINA; BOTTLE-NOSED DOLPHINS; BEARS URSUS-MARITIMUS; MATCHED CASE-CONTROL; QUASIMEME LABORATORY-PERFORMANCE; BALTIC SEA; ENVIRONMENTAL CONTAMINANTS; MARINE MAMMALS; SELECTION BIAS; DELPHINAPTERUS-LEUCAS; Delphinapterus leucas; Phoca vitulina; Phocoena phocoena; Ursus maritimus
• Online Access: https://research-portal.st-andrews.ac.uk/en/publications/04a834d1-c3e9-4846-99d0-850714f50e14; https://doi.org/10.1289/ehp.8222; http://www.ehponline.org/members/2006/8222/8222.html

The objective of this study was to determine whether the risk of mortality from infectious disease in harbor porpoise in U.K. waters increased with high exposure to polychlorinated biphenyls (PCBs), using a case-control study design. This is the first time that data from a long-term marine mammal strandings scheme have been used to estimate any increase in risk The exposure odds ratio (OR) from a logistic regression model with infectious disease deaths as cases and physical trauma deaths as controls, after controlling for the effect of confounding factors, was 1.048 [95% confidence interval (0), 1.02-1.07]. To further adjust for the difference in energetic status between cases and controls and account for the negative relationship between PCBs (sum of 25 chlorobiphenyl congeners) and blubber mass, we also "standardized" the blubber PCBs to an optimal blubber mass. This lowered the OR to 1.02 (95% Cl, 1.00-1-03). Thus, for each 1 mg/kg increase in blubber PcBs, the average increase in risk of infectious disease mortality was 2%. A doubling of risk occurred at approximately 45 mg/kg lipid. In this study, we have endeavored to avoid selection bias by using controls that died of physical trauma as representative of the exposure prevalence in the population that gave rise to the cases. In addition, we controlled for the effect of variation in energetic status among the cases and controls. However, as with case-control studies in human and veterinary epidemiology, unforeseen misclassification errors may result in biased risk estimates in either direction.