A predictive model for canine dilated cardiomyopathy: a meta-analysis of Doberman Pinscher data
Dilated cardiomyopathy is a prevalent and often fatal disease in humans and dogs. Indeed dilated cardiomyopathy is the third most common form of cardiac disease in humans, reported to affect approximately 36 individuals per 100,000 individuals. In dogs, dilated cardiomyopathy is the second most comm...
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ftunottingham:oai:eprints.nottingham.ac.uk:29025 2023-09-05T13:21:13+02:00 A predictive model for canine dilated cardiomyopathy: a meta-analysis of Doberman Pinscher data Simpson, Siobhan Edwards, Jennifer Emes, Richard D. Cobb, Malcolm A. Mongan, Nigel P. Rutland, Catrin S. 2015-03-26 http://eprints.nottingham.ac.uk/29025/ https://doi.org/10.7717/peerj.842 unknown PeerJ Simpson, Siobhan and Edwards, Jennifer and Emes, Richard D. and Cobb, Malcolm A. and Mongan, Nigel P. and Rutland, Catrin S. (2015) A predictive model for canine dilated cardiomyopathy: a meta-analysis of Doberman Pinscher data. PeerJ, 3 . e842/1-e842/16. ISSN 2167-8359 doi:10.7717/peerj.842 Article PeerReviewed 2015 ftunottingham https://doi.org/10.7717/peerj.842 2023-08-14T17:33:26Z Dilated cardiomyopathy is a prevalent and often fatal disease in humans and dogs. Indeed dilated cardiomyopathy is the third most common form of cardiac disease in humans, reported to affect approximately 36 individuals per 100,000 individuals. In dogs, dilated cardiomyopathy is the second most common cardiac disease and is most prevalent in the Irish Wolfhound, Doberman Pinscher and Newfoundland breeds. Dilated cardiomyopathy is characterised by ventricular chamber enlargement and systolic dysfunction which often leads to congestive heart failure. Although multiple human loci have been implicated in the pathogenesis of dilated cardiomyopathy, the identified variants are typically associated with rare monogenic forms of dilated cardiomyopathy. The potential for multigenic interactions contributing to human dilated cardiomyopathy remains poorly understood. Consistent with this, several known human dilated cardiomyopathy loci have been excluded as common causes of canine dilated cardiomyopathy, although canine dilated cardiomyopathy resembles the human disease functionally. This suggests additional genetic factors contribute to the dilated cardiomyopathy phenotype. This study represents a meta-analysis of available canine dilated cardiomyopathy genetic datasets with the goal of determining potential multigenic interactions relating the sex chromosome genotype (XX vs. XY) with known dilated cardiomyopathy associated loci on chromosome 5 and the PDK4 gene in the incidence and progression of dilated cardiomyopathy. The results show an interaction between known canine dilated cardiomyopathy loci and an unknown X-linked locus. Our study is the first to test a multigenic contribution to dilated cardiomyopathy and suggest a genetic basis for the known sex-disparity in dilated cardiomyopathy outcomes. Article in Journal/Newspaper Newfoundland The University of Nottingham: Nottingham ePrints PeerJ 3 e842 |
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Dilated cardiomyopathy is a prevalent and often fatal disease in humans and dogs. Indeed dilated cardiomyopathy is the third most common form of cardiac disease in humans, reported to affect approximately 36 individuals per 100,000 individuals. In dogs, dilated cardiomyopathy is the second most common cardiac disease and is most prevalent in the Irish Wolfhound, Doberman Pinscher and Newfoundland breeds. Dilated cardiomyopathy is characterised by ventricular chamber enlargement and systolic dysfunction which often leads to congestive heart failure. Although multiple human loci have been implicated in the pathogenesis of dilated cardiomyopathy, the identified variants are typically associated with rare monogenic forms of dilated cardiomyopathy. The potential for multigenic interactions contributing to human dilated cardiomyopathy remains poorly understood. Consistent with this, several known human dilated cardiomyopathy loci have been excluded as common causes of canine dilated cardiomyopathy, although canine dilated cardiomyopathy resembles the human disease functionally. This suggests additional genetic factors contribute to the dilated cardiomyopathy phenotype. This study represents a meta-analysis of available canine dilated cardiomyopathy genetic datasets with the goal of determining potential multigenic interactions relating the sex chromosome genotype (XX vs. XY) with known dilated cardiomyopathy associated loci on chromosome 5 and the PDK4 gene in the incidence and progression of dilated cardiomyopathy. The results show an interaction between known canine dilated cardiomyopathy loci and an unknown X-linked locus. Our study is the first to test a multigenic contribution to dilated cardiomyopathy and suggest a genetic basis for the known sex-disparity in dilated cardiomyopathy outcomes. |
format |
Article in Journal/Newspaper |
author |
Simpson, Siobhan Edwards, Jennifer Emes, Richard D. Cobb, Malcolm A. Mongan, Nigel P. Rutland, Catrin S. |
spellingShingle |
Simpson, Siobhan Edwards, Jennifer Emes, Richard D. Cobb, Malcolm A. Mongan, Nigel P. Rutland, Catrin S. A predictive model for canine dilated cardiomyopathy: a meta-analysis of Doberman Pinscher data |
author_facet |
Simpson, Siobhan Edwards, Jennifer Emes, Richard D. Cobb, Malcolm A. Mongan, Nigel P. Rutland, Catrin S. |
author_sort |
Simpson, Siobhan |
title |
A predictive model for canine dilated cardiomyopathy: a meta-analysis of Doberman Pinscher data |
title_short |
A predictive model for canine dilated cardiomyopathy: a meta-analysis of Doberman Pinscher data |
title_full |
A predictive model for canine dilated cardiomyopathy: a meta-analysis of Doberman Pinscher data |
title_fullStr |
A predictive model for canine dilated cardiomyopathy: a meta-analysis of Doberman Pinscher data |
title_full_unstemmed |
A predictive model for canine dilated cardiomyopathy: a meta-analysis of Doberman Pinscher data |
title_sort |
predictive model for canine dilated cardiomyopathy: a meta-analysis of doberman pinscher data |
publisher |
PeerJ |
publishDate |
2015 |
url |
http://eprints.nottingham.ac.uk/29025/ https://doi.org/10.7717/peerj.842 |
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Newfoundland |
genre_facet |
Newfoundland |
op_relation |
Simpson, Siobhan and Edwards, Jennifer and Emes, Richard D. and Cobb, Malcolm A. and Mongan, Nigel P. and Rutland, Catrin S. (2015) A predictive model for canine dilated cardiomyopathy: a meta-analysis of Doberman Pinscher data. PeerJ, 3 . e842/1-e842/16. ISSN 2167-8359 doi:10.7717/peerj.842 |
op_doi |
https://doi.org/10.7717/peerj.842 |
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PeerJ |
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3 |
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e842 |
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1776201820679438336 |