Modern diet and metabolic variance – a recipe for disaster?
Objective Recently, a positive correlation between alanine transaminase activity and body mass was established among healthy young individuals of normal weight. Here we explore further this relationship and propose a physiological rationale for this link. Design Cross-sectional statistical analysis...
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ftunivzuerich:oai:www.zora.uzh.ch:98241 2024-06-23T07:52:33+00:00 Modern diet and metabolic variance – a recipe for disaster? Grantham, James P Staub, Kaspar Rühli, Frank J Henneberg, Maciej 2014 application/pdf https://www.zora.uzh.ch/id/eprint/98241/ https://www.zora.uzh.ch/id/eprint/98241/1/1475-2891-13-15.pdf https://doi.org/10.5167/uzh-98241 https://doi.org/10.1186/1475-2891-13-15 eng eng BioMed Central https://www.zora.uzh.ch/id/eprint/98241/1/1475-2891-13-15.pdf doi:10.5167/uzh-98241 doi:10.1186/1475-2891-13-15 info:pmid/24502225 urn:issn:1475-2891 info:eu-repo/semantics/openAccess Creative Commons: Attribution 2.0 Generic (CC BY 2.0) http://creativecommons.org/licenses/by/2.0/ Grantham, James P; Staub, Kaspar; Rühli, Frank J; Henneberg, Maciej (2014). Modern diet and metabolic variance – a recipe for disaster? Nutrition Journal, 13:15. Institute of Evolutionary Medicine 570 Life sciences biology 610 Medicine & health Journal Article PeerReviewed info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2014 ftunivzuerich https://doi.org/10.5167/uzh-9824110.1186/1475-2891-13-15 2024-06-12T00:34:11Z Objective Recently, a positive correlation between alanine transaminase activity and body mass was established among healthy young individuals of normal weight. Here we explore further this relationship and propose a physiological rationale for this link. Design Cross-sectional statistical analysis of adiposity across large samples of adults differing by age, diet and lifestyle. Subjects 46,684 19-20 years old Swiss male conscripts and published data on 1000 Eskimos, 518 Toronto residents and 97,000 North American Adventists. Measurements Serum concentrations of the alanine transaminase, post-prandial glucose levels, cholesterol, body height and weight, blood pressure and routine blood analysis (thrombocytes and leukocytes) for Swiss conscripts. Adiposity measures and dietary information for other groups were also obtained. Results Stepwise multiple regression after correction for random errors of physiological tests showed that 28% of the total variance in body mass is associated with ALT concentrations. This relationship remained significant when only metabolically healthy (as defined by the American Heart Association) Swiss conscripts were selected. The data indicated that high protein only or high carbohydrate only diets are associated with lower levels of obesity than a diet combining proteins and carbohydrates. Conclusion Elevated levels of alanine transaminase, and likely other transaminases, may result in overactivity of the alanine cycle that produces pyruvate from protein. When a mixed meal of protein, carbohydrate and fat is consumed, carbohydrates and fats are digested faster and metabolised to satisfy body’s energetic needs while slower digested protein is ultimately converted to malonyl CoA and stored as fat. Chronicity of this sequence is proposed to cause accumulation of somatic fat stores and thus obesity. Article in Journal/Newspaper eskimo* University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
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University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
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ftunivzuerich |
language |
English |
topic |
Institute of Evolutionary Medicine 570 Life sciences biology 610 Medicine & health |
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Institute of Evolutionary Medicine 570 Life sciences biology 610 Medicine & health Grantham, James P Staub, Kaspar Rühli, Frank J Henneberg, Maciej Modern diet and metabolic variance – a recipe for disaster? |
topic_facet |
Institute of Evolutionary Medicine 570 Life sciences biology 610 Medicine & health |
description |
Objective Recently, a positive correlation between alanine transaminase activity and body mass was established among healthy young individuals of normal weight. Here we explore further this relationship and propose a physiological rationale for this link. Design Cross-sectional statistical analysis of adiposity across large samples of adults differing by age, diet and lifestyle. Subjects 46,684 19-20 years old Swiss male conscripts and published data on 1000 Eskimos, 518 Toronto residents and 97,000 North American Adventists. Measurements Serum concentrations of the alanine transaminase, post-prandial glucose levels, cholesterol, body height and weight, blood pressure and routine blood analysis (thrombocytes and leukocytes) for Swiss conscripts. Adiposity measures and dietary information for other groups were also obtained. Results Stepwise multiple regression after correction for random errors of physiological tests showed that 28% of the total variance in body mass is associated with ALT concentrations. This relationship remained significant when only metabolically healthy (as defined by the American Heart Association) Swiss conscripts were selected. The data indicated that high protein only or high carbohydrate only diets are associated with lower levels of obesity than a diet combining proteins and carbohydrates. Conclusion Elevated levels of alanine transaminase, and likely other transaminases, may result in overactivity of the alanine cycle that produces pyruvate from protein. When a mixed meal of protein, carbohydrate and fat is consumed, carbohydrates and fats are digested faster and metabolised to satisfy body’s energetic needs while slower digested protein is ultimately converted to malonyl CoA and stored as fat. Chronicity of this sequence is proposed to cause accumulation of somatic fat stores and thus obesity. |
format |
Article in Journal/Newspaper |
author |
Grantham, James P Staub, Kaspar Rühli, Frank J Henneberg, Maciej |
author_facet |
Grantham, James P Staub, Kaspar Rühli, Frank J Henneberg, Maciej |
author_sort |
Grantham, James P |
title |
Modern diet and metabolic variance – a recipe for disaster? |
title_short |
Modern diet and metabolic variance – a recipe for disaster? |
title_full |
Modern diet and metabolic variance – a recipe for disaster? |
title_fullStr |
Modern diet and metabolic variance – a recipe for disaster? |
title_full_unstemmed |
Modern diet and metabolic variance – a recipe for disaster? |
title_sort |
modern diet and metabolic variance – a recipe for disaster? |
publisher |
BioMed Central |
publishDate |
2014 |
url |
https://www.zora.uzh.ch/id/eprint/98241/ https://www.zora.uzh.ch/id/eprint/98241/1/1475-2891-13-15.pdf https://doi.org/10.5167/uzh-98241 https://doi.org/10.1186/1475-2891-13-15 |
genre |
eskimo* |
genre_facet |
eskimo* |
op_source |
Grantham, James P; Staub, Kaspar; Rühli, Frank J; Henneberg, Maciej (2014). Modern diet and metabolic variance – a recipe for disaster? Nutrition Journal, 13:15. |
op_relation |
https://www.zora.uzh.ch/id/eprint/98241/1/1475-2891-13-15.pdf doi:10.5167/uzh-98241 doi:10.1186/1475-2891-13-15 info:pmid/24502225 urn:issn:1475-2891 |
op_rights |
info:eu-repo/semantics/openAccess Creative Commons: Attribution 2.0 Generic (CC BY 2.0) http://creativecommons.org/licenses/by/2.0/ |
op_doi |
https://doi.org/10.5167/uzh-9824110.1186/1475-2891-13-15 |
_version_ |
1802643883453054976 |