Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes
INTRODUCTION: Modic changes (MC) are bone marrow lesions of vertebral bones, which can be detected with magnetic resonance imaging (MRI) adjacent to degenerated intervertebral discs. Defined by their appearance on T1 and T2 weighted images, there are three interconvertible types: MC1, MC2, and MC3....
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2024
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ftunivzuerich:oai:www.zora.uzh.ch:261842 2024-09-30T14:40:07+00:00 Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes Schulze, Friederike Määttä, Juhani Grad, Sybille Heggli, Irina Brunner, Florian Farshad, Mazda Distler, Oliver Karppinen, Jaro Lotz, Jeffrey Dudli, Stefan 2024-09 application/pdf https://www.zora.uzh.ch/id/eprint/261842/ https://www.zora.uzh.ch/id/eprint/261842/1/ZORA_261842.pdf https://doi.org/10.5167/uzh-261842 https://doi.org/10.1002/jsp2.1337 eng eng Wiley Open Access https://www.zora.uzh.ch/id/eprint/261842/1/ZORA_261842.pdf doi:10.5167/uzh-261842 doi:10.1002/jsp2.1337 info:pmid/39015135 urn:issn:2572-1143 info:eu-repo/semantics/openAccess Creative Commons: Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/ Schulze, Friederike; Määttä, Juhani; Grad, Sybille; Heggli, Irina; Brunner, Florian; Farshad, Mazda; Distler, Oliver; Karppinen, Jaro; Lotz, Jeffrey; Dudli, Stefan (2024). Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes. JOR Spine, 7(3):e1337. Rheumatology Clinic and Institute of Physical Medicine 610 Medicine & health Journal Article PeerReviewed info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2024 ftunivzuerich https://doi.org/10.5167/uzh-26184210.1002/jsp2.1337 2024-09-04T00:39:04Z INTRODUCTION: Modic changes (MC) are bone marrow lesions of vertebral bones, which can be detected with magnetic resonance imaging (MRI) adjacent to degenerated intervertebral discs. Defined by their appearance on T1 and T2 weighted images, there are three interconvertible types: MC1, MC2, and MC3. The inter-observer variability of the MRI diagnosis is high, therefore a diagnostic serum biomarker complementing the MRI to facilitate diagnosis and follow-up would be of great value. METHODS: We used a highly sensitive and reproducible proteomics approach: DIA/SWATH-MS to find serum biomarkers in a subset of the Northern Finland Birth Cohort 1966. Separately, we measured a panel of factors involved in inflammation and angiogenesis to confirm some potential biomarkers published before with an ELISA-based method called V-Plex. RESULTS: We found neither an association between the serum concentrations of the proteins detected with DIA/SWATH-MS with the presence of MC, nor a correlation with the size of the MC lesions. We did not find any association between the factors measured with the V-Plex and the presence of MC or their size. CONCLUSION: Altogether, our study suggests that a robust and generally usable biomarker to facilitate the diagnosis of MC cannot readily be found in serum. Article in Journal/Newspaper Northern Finland University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
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Open Polar |
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University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
op_collection_id |
ftunivzuerich |
language |
English |
topic |
Rheumatology Clinic and Institute of Physical Medicine 610 Medicine & health |
spellingShingle |
Rheumatology Clinic and Institute of Physical Medicine 610 Medicine & health Schulze, Friederike Määttä, Juhani Grad, Sybille Heggli, Irina Brunner, Florian Farshad, Mazda Distler, Oliver Karppinen, Jaro Lotz, Jeffrey Dudli, Stefan Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes |
topic_facet |
Rheumatology Clinic and Institute of Physical Medicine 610 Medicine & health |
description |
INTRODUCTION: Modic changes (MC) are bone marrow lesions of vertebral bones, which can be detected with magnetic resonance imaging (MRI) adjacent to degenerated intervertebral discs. Defined by their appearance on T1 and T2 weighted images, there are three interconvertible types: MC1, MC2, and MC3. The inter-observer variability of the MRI diagnosis is high, therefore a diagnostic serum biomarker complementing the MRI to facilitate diagnosis and follow-up would be of great value. METHODS: We used a highly sensitive and reproducible proteomics approach: DIA/SWATH-MS to find serum biomarkers in a subset of the Northern Finland Birth Cohort 1966. Separately, we measured a panel of factors involved in inflammation and angiogenesis to confirm some potential biomarkers published before with an ELISA-based method called V-Plex. RESULTS: We found neither an association between the serum concentrations of the proteins detected with DIA/SWATH-MS with the presence of MC, nor a correlation with the size of the MC lesions. We did not find any association between the factors measured with the V-Plex and the presence of MC or their size. CONCLUSION: Altogether, our study suggests that a robust and generally usable biomarker to facilitate the diagnosis of MC cannot readily be found in serum. |
format |
Article in Journal/Newspaper |
author |
Schulze, Friederike Määttä, Juhani Grad, Sybille Heggli, Irina Brunner, Florian Farshad, Mazda Distler, Oliver Karppinen, Jaro Lotz, Jeffrey Dudli, Stefan |
author_facet |
Schulze, Friederike Määttä, Juhani Grad, Sybille Heggli, Irina Brunner, Florian Farshad, Mazda Distler, Oliver Karppinen, Jaro Lotz, Jeffrey Dudli, Stefan |
author_sort |
Schulze, Friederike |
title |
Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes |
title_short |
Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes |
title_full |
Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes |
title_fullStr |
Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes |
title_full_unstemmed |
Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes |
title_sort |
proteomic analysis of serum in a population-based cohort did not reveal a biomarker for modic changes |
publisher |
Wiley Open Access |
publishDate |
2024 |
url |
https://www.zora.uzh.ch/id/eprint/261842/ https://www.zora.uzh.ch/id/eprint/261842/1/ZORA_261842.pdf https://doi.org/10.5167/uzh-261842 https://doi.org/10.1002/jsp2.1337 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Schulze, Friederike; Määttä, Juhani; Grad, Sybille; Heggli, Irina; Brunner, Florian; Farshad, Mazda; Distler, Oliver; Karppinen, Jaro; Lotz, Jeffrey; Dudli, Stefan (2024). Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes. JOR Spine, 7(3):e1337. |
op_relation |
https://www.zora.uzh.ch/id/eprint/261842/1/ZORA_261842.pdf doi:10.5167/uzh-261842 doi:10.1002/jsp2.1337 info:pmid/39015135 urn:issn:2572-1143 |
op_rights |
info:eu-repo/semantics/openAccess Creative Commons: Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.5167/uzh-26184210.1002/jsp2.1337 |
_version_ |
1811642654225596416 |