The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts
Background: Necrotizing fasciitis (NF) is a serious infectious disease that can initially place the patient’s life in danger and, after successful surgical and antibiotic treatment, leaves extensive wounds with sometimes even exposed bones and tendons. Autologous skin grafts are not always possible...
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MDPI Publishing
2023
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ftunivzuerich:oai:www.zora.uzh.ch:251547 2024-09-15T18:14:37+00:00 The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts Dueppers, Philip Bozalka, Roland Kopp, Reinhard Menges, Anna-Leonie Reutersberg, Benedikt Schrimpf, Claudia Moreno Rivero, Francisco Jose Zimmermann, Alexander 2023-09-16 application/pdf https://www.zora.uzh.ch/id/eprint/251547/ https://www.zora.uzh.ch/id/eprint/251547/1/ZORA_pdf_version_1695029483.pdf https://doi.org/10.5167/uzh-251547 https://doi.org/10.3390/jcm12186001 eng eng MDPI Publishing https://www.zora.uzh.ch/id/eprint/251547/1/ZORA_pdf_version_1695029483.pdf doi:10.5167/uzh-251547 doi:10.3390/jcm12186001 info:pmid/37762941 urn:issn:2077-0383 info:eu-repo/semantics/openAccess Creative Commons: Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/ Dueppers, Philip; Bozalka, Roland; Kopp, Reinhard; Menges, Anna-Leonie; Reutersberg, Benedikt; Schrimpf, Claudia; Moreno Rivero, Francisco Jose; Zimmermann, Alexander (2023). The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts. Journal of Clinical Medicine, 12(18):6001. Clinic for Vascular Surgery 610 Medicine & health General Medicine Journal Article PeerReviewed info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2023 ftunivzuerich https://doi.org/10.5167/uzh-25154710.3390/jcm12186001 2024-09-04T00:39:08Z Background: Necrotizing fasciitis (NF) is a serious infectious disease that can initially place the patient’s life in danger and, after successful surgical and antibiotic treatment, leaves extensive wounds with sometimes even exposed bones and tendons. Autologous skin grafts are not always possible or require adequate wound bed preparation. Novel intact fish skin grafts (iFSGs; Kerecis® Omega3 Wound, Kerecis hf, Isafjördur, Iceland) have already shown their potential to promote granulation in many other wound situations. Faster wound healing rates and better functional and cosmetic outcomes were observed due to their additionally postulated anti-inflammatory and analgesic properties. Therefore, iFSGs may also be essential in treating NF. We present our initial experience with iFSGs in treating leg wounds after NF and review the literature for the current spectrum of clinical use of iFSGs. Case Presentations: We present two male patients (aged 60 and 69 years) with chronic or acute postsurgical extensive leg ulcers six weeks and six days after necrotizing fasciitis, respectively. Both suffered from diabetes mellitus without vascular pathologies of the lower limbs. A single application of one pre-meshed (Kerecis® Graftguide) and one self-meshed 300 cm2 iFSG (Kerecis® Surgiclose) was performed in our operation room after extensive surgical debridement and single circles of negative wound pressure therapy. Application and handling were easy. An excellent wound granulation was observed, even in uncovered tibia bone and tendons, accompanied by pain relief in both patients. Neither complications nor allergic reactions occurred. The patients received autologous skin grafting with excellent functional and cosmetic outcomes. Conclusions: iFSGs have the potential to play a significant role in the future treatment of NF due to the fast promotion of wound granulation and pain relief. Our experience may encourage surgeons to use iFSGs in NF patients, although high-quality, large-sized studies are still required to confirm ... Article in Journal/Newspaper Iceland University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
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Open Polar |
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University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
op_collection_id |
ftunivzuerich |
language |
English |
topic |
Clinic for Vascular Surgery 610 Medicine & health General Medicine |
spellingShingle |
Clinic for Vascular Surgery 610 Medicine & health General Medicine Dueppers, Philip Bozalka, Roland Kopp, Reinhard Menges, Anna-Leonie Reutersberg, Benedikt Schrimpf, Claudia Moreno Rivero, Francisco Jose Zimmermann, Alexander The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts |
topic_facet |
Clinic for Vascular Surgery 610 Medicine & health General Medicine |
description |
Background: Necrotizing fasciitis (NF) is a serious infectious disease that can initially place the patient’s life in danger and, after successful surgical and antibiotic treatment, leaves extensive wounds with sometimes even exposed bones and tendons. Autologous skin grafts are not always possible or require adequate wound bed preparation. Novel intact fish skin grafts (iFSGs; Kerecis® Omega3 Wound, Kerecis hf, Isafjördur, Iceland) have already shown their potential to promote granulation in many other wound situations. Faster wound healing rates and better functional and cosmetic outcomes were observed due to their additionally postulated anti-inflammatory and analgesic properties. Therefore, iFSGs may also be essential in treating NF. We present our initial experience with iFSGs in treating leg wounds after NF and review the literature for the current spectrum of clinical use of iFSGs. Case Presentations: We present two male patients (aged 60 and 69 years) with chronic or acute postsurgical extensive leg ulcers six weeks and six days after necrotizing fasciitis, respectively. Both suffered from diabetes mellitus without vascular pathologies of the lower limbs. A single application of one pre-meshed (Kerecis® Graftguide) and one self-meshed 300 cm2 iFSG (Kerecis® Surgiclose) was performed in our operation room after extensive surgical debridement and single circles of negative wound pressure therapy. Application and handling were easy. An excellent wound granulation was observed, even in uncovered tibia bone and tendons, accompanied by pain relief in both patients. Neither complications nor allergic reactions occurred. The patients received autologous skin grafting with excellent functional and cosmetic outcomes. Conclusions: iFSGs have the potential to play a significant role in the future treatment of NF due to the fast promotion of wound granulation and pain relief. Our experience may encourage surgeons to use iFSGs in NF patients, although high-quality, large-sized studies are still required to confirm ... |
format |
Article in Journal/Newspaper |
author |
Dueppers, Philip Bozalka, Roland Kopp, Reinhard Menges, Anna-Leonie Reutersberg, Benedikt Schrimpf, Claudia Moreno Rivero, Francisco Jose Zimmermann, Alexander |
author_facet |
Dueppers, Philip Bozalka, Roland Kopp, Reinhard Menges, Anna-Leonie Reutersberg, Benedikt Schrimpf, Claudia Moreno Rivero, Francisco Jose Zimmermann, Alexander |
author_sort |
Dueppers, Philip |
title |
The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts |
title_short |
The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts |
title_full |
The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts |
title_fullStr |
The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts |
title_full_unstemmed |
The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts |
title_sort |
use of intact fish skin grafts in the treatment of necrotizing fasciitis of the leg: early clinical experience and literature review on indications for intact fish skin grafts |
publisher |
MDPI Publishing |
publishDate |
2023 |
url |
https://www.zora.uzh.ch/id/eprint/251547/ https://www.zora.uzh.ch/id/eprint/251547/1/ZORA_pdf_version_1695029483.pdf https://doi.org/10.5167/uzh-251547 https://doi.org/10.3390/jcm12186001 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Dueppers, Philip; Bozalka, Roland; Kopp, Reinhard; Menges, Anna-Leonie; Reutersberg, Benedikt; Schrimpf, Claudia; Moreno Rivero, Francisco Jose; Zimmermann, Alexander (2023). The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts. Journal of Clinical Medicine, 12(18):6001. |
op_relation |
https://www.zora.uzh.ch/id/eprint/251547/1/ZORA_pdf_version_1695029483.pdf doi:10.5167/uzh-251547 doi:10.3390/jcm12186001 info:pmid/37762941 urn:issn:2077-0383 |
op_rights |
info:eu-repo/semantics/openAccess Creative Commons: Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.5167/uzh-25154710.3390/jcm12186001 |
_version_ |
1810452399505014784 |