Longitudinal analysis of allergen-specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horses
BACKGROUND: Insect bite hypersensitivity (IBH) is an allergic dermatitis of horses caused by bites of Culicoides spp. IBH does not occur in Iceland because of the absence of Culicoides, but the prevalence is high in horses imported from Iceland to environments where Culicoides are present. HYPOTHESI...
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2018
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Online Access: | https://www.zora.uzh.ch/id/eprint/145863/ https://www.zora.uzh.ch/145863 https://doi.org/10.1111/vde.12493 |
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ftunivzuerich:oai:www.zora.uzh.ch:145863 2024-10-13T14:08:21+00:00 Longitudinal analysis of allergen-specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horses Ziegler, Anja Hamza, Eman Jonsdottir, Sigridur Rhyner, Claudio Wagner, Bettina Schüpbach, Gertraud Svansson, Vilhjalmur Torsteinsdottir, Sigurbjorg Marti, Eliane 2018-10-05 https://www.zora.uzh.ch/id/eprint/145863/ https://www.zora.uzh.ch/145863 https://doi.org/10.1111/vde.12493 eng eng Wiley-Blackwell Publishing, Inc. https://www.zora.uzh.ch/145863 doi:10.1111/vde.12493 info:pmid/28980353 urn:issn:0959-4493 info:eu-repo/semantics/closedAccess Ziegler, Anja; Hamza, Eman; Jonsdottir, Sigridur; Rhyner, Claudio; Wagner, Bettina; Schüpbach, Gertraud; Svansson, Vilhjalmur; Torsteinsdottir, Sigurbjorg; Marti, Eliane (2018). Longitudinal analysis of allergen-specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horses. Veterinary Dermatology, 29(1):51-e22. Swiss Institute of Allergy and Asthma Research 610 Medicine & health Journal Article PeerReviewed info:eu-repo/semantics/article 2018 ftunivzuerich https://doi.org/10.1111/vde.12493 2024-09-18T00:49:49Z BACKGROUND: Insect bite hypersensitivity (IBH) is an allergic dermatitis of horses caused by bites of Culicoides spp. IBH does not occur in Iceland because of the absence of Culicoides, but the prevalence is high in horses imported from Iceland to environments where Culicoides are present. HYPOTHESIS/OBJECTIVE: Test, in a longitudinal study before and after Culicoides exposure, whether a primary sensitizing Culicoides allergen can be identified and if an increase of allergen-specific immunoglobulin (Ig)E or IgG subclasses precedes clinical signs of IBH. ANIMALS: Thirty two horses imported from Iceland to Europe; 16 developed IBH and 16 remained healthy. METHODS: Determination of IgE and IgG subclasses against recombinant (r)-Culicoides allergens and Culicoides extract in sera taken before first exposure to Culicoides and yearly over a period of 3-4 years. RESULTS: Before Culicoides exposure, there were no significant differences in Culicoides-specific serum IgE levels between horse that developed IBH or remained healthy. Culicoides exposure induced an individual IgE response pattern (to a median of 4.5 r-allergens) in the IBH but not in the healthy end-point group. The increase in serum IgE levels to Culicoides r-allergens was concurrent with the initial onset of clinical signs of IBH. IBH-affected horses displayed significantly higher allergen-specific IgG1 and IgG5 levels than healthy controls. Recombinant Culicoides obsoletus 1 (Cul o1) and Cul o3-specific IgG5 was significantly higher in the IBH compared to the healthy end-point group, before clinical signs of IBH. CONCLUSION/CLINICAL RELEVANCE: Allergen-specific serum IgE cannot be used as predictor for IBH, whereas allergen-specific IgG5 levels may have a predictive value. Article in Journal/Newspaper Iceland University of Zurich (UZH): ZORA (Zurich Open Repository and Archive Veterinary Dermatology 29 1 51 e22 |
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Open Polar |
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University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
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ftunivzuerich |
language |
English |
topic |
Swiss Institute of Allergy and Asthma Research 610 Medicine & health |
spellingShingle |
Swiss Institute of Allergy and Asthma Research 610 Medicine & health Ziegler, Anja Hamza, Eman Jonsdottir, Sigridur Rhyner, Claudio Wagner, Bettina Schüpbach, Gertraud Svansson, Vilhjalmur Torsteinsdottir, Sigurbjorg Marti, Eliane Longitudinal analysis of allergen-specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horses |
topic_facet |
Swiss Institute of Allergy and Asthma Research 610 Medicine & health |
description |
BACKGROUND: Insect bite hypersensitivity (IBH) is an allergic dermatitis of horses caused by bites of Culicoides spp. IBH does not occur in Iceland because of the absence of Culicoides, but the prevalence is high in horses imported from Iceland to environments where Culicoides are present. HYPOTHESIS/OBJECTIVE: Test, in a longitudinal study before and after Culicoides exposure, whether a primary sensitizing Culicoides allergen can be identified and if an increase of allergen-specific immunoglobulin (Ig)E or IgG subclasses precedes clinical signs of IBH. ANIMALS: Thirty two horses imported from Iceland to Europe; 16 developed IBH and 16 remained healthy. METHODS: Determination of IgE and IgG subclasses against recombinant (r)-Culicoides allergens and Culicoides extract in sera taken before first exposure to Culicoides and yearly over a period of 3-4 years. RESULTS: Before Culicoides exposure, there were no significant differences in Culicoides-specific serum IgE levels between horse that developed IBH or remained healthy. Culicoides exposure induced an individual IgE response pattern (to a median of 4.5 r-allergens) in the IBH but not in the healthy end-point group. The increase in serum IgE levels to Culicoides r-allergens was concurrent with the initial onset of clinical signs of IBH. IBH-affected horses displayed significantly higher allergen-specific IgG1 and IgG5 levels than healthy controls. Recombinant Culicoides obsoletus 1 (Cul o1) and Cul o3-specific IgG5 was significantly higher in the IBH compared to the healthy end-point group, before clinical signs of IBH. CONCLUSION/CLINICAL RELEVANCE: Allergen-specific serum IgE cannot be used as predictor for IBH, whereas allergen-specific IgG5 levels may have a predictive value. |
format |
Article in Journal/Newspaper |
author |
Ziegler, Anja Hamza, Eman Jonsdottir, Sigridur Rhyner, Claudio Wagner, Bettina Schüpbach, Gertraud Svansson, Vilhjalmur Torsteinsdottir, Sigurbjorg Marti, Eliane |
author_facet |
Ziegler, Anja Hamza, Eman Jonsdottir, Sigridur Rhyner, Claudio Wagner, Bettina Schüpbach, Gertraud Svansson, Vilhjalmur Torsteinsdottir, Sigurbjorg Marti, Eliane |
author_sort |
Ziegler, Anja |
title |
Longitudinal analysis of allergen-specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horses |
title_short |
Longitudinal analysis of allergen-specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horses |
title_full |
Longitudinal analysis of allergen-specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horses |
title_fullStr |
Longitudinal analysis of allergen-specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horses |
title_full_unstemmed |
Longitudinal analysis of allergen-specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horses |
title_sort |
longitudinal analysis of allergen-specific ige and igg subclasses as potential predictors of insect bite hypersensitivity following first exposure to culicoides in icelandic horses |
publisher |
Wiley-Blackwell Publishing, Inc. |
publishDate |
2018 |
url |
https://www.zora.uzh.ch/id/eprint/145863/ https://www.zora.uzh.ch/145863 https://doi.org/10.1111/vde.12493 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Ziegler, Anja; Hamza, Eman; Jonsdottir, Sigridur; Rhyner, Claudio; Wagner, Bettina; Schüpbach, Gertraud; Svansson, Vilhjalmur; Torsteinsdottir, Sigurbjorg; Marti, Eliane (2018). Longitudinal analysis of allergen-specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horses. Veterinary Dermatology, 29(1):51-e22. |
op_relation |
https://www.zora.uzh.ch/145863 doi:10.1111/vde.12493 info:pmid/28980353 urn:issn:0959-4493 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1111/vde.12493 |
container_title |
Veterinary Dermatology |
container_volume |
29 |
container_issue |
1 |
container_start_page |
51 |
op_container_end_page |
e22 |
_version_ |
1812815027088916480 |