Clinical and molecular investigation of a canine distemper outbreak and vector-borne infections in a group of rescue dogs imported from Hungary to Switzerland
BACKGROUND Canine distemper virus (CDV) is a major pathogen of dogs and wild carnivores worldwide. In Switzerland, distemper in domestic dogs is rarely reported. In recent years, the import of dogs from Eastern Europe to Switzerland has steadily increased. In the present study, we describe a distemp...
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ftunivzuerich:oai:www.zora.uzh.ch:111788 2024-09-09T19:25:24+00:00 Clinical and molecular investigation of a canine distemper outbreak and vector-borne infections in a group of rescue dogs imported from Hungary to Switzerland Willi, Barbara Spiri, Andrea M Meli, Marina L Grimm, Felix Beatrice, Laura Riond, Barbara Bley, T Jordi, R Dennler, Matthias Hofmann-Lehmann, Regina 2015 application/pdf https://www.zora.uzh.ch/id/eprint/111788/ https://www.zora.uzh.ch/id/eprint/111788/1/Willi_BMC_Vet_Res_2015.pdf https://doi.org/10.5167/uzh-111788 https://doi.org/10.1186/s12917-015-0471-0 eng eng BioMed Central https://www.zora.uzh.ch/id/eprint/111788/1/Willi_BMC_Vet_Res_2015.pdf doi:10.5167/uzh-111788 doi:10.1186/s12917-015-0471-0 info:pmid/26179635 urn:issn:1746-6148 info:eu-repo/semantics/openAccess Creative Commons: Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/ Willi, Barbara; Spiri, Andrea M; Meli, Marina L; Grimm, Felix; Beatrice, Laura; Riond, Barbara; Bley, T; Jordi, R; Dennler, Matthias; Hofmann-Lehmann, Regina (2015). Clinical and molecular investigation of a canine distemper outbreak and vector-borne infections in a group of rescue dogs imported from Hungary to Switzerland. BMC Veterinary Research, 11:154. Institute of Parasitology Department of Farm Animals Department of Small Animals Department of Clinical Diagnostics and Services Center for Clinical Studies 570 Life sciences biology 630 Agriculture Canine distemper virus Outbreak Domestic dog Import Vector-borne infections Phylogenetic analysis Vaccination Arctic-like lineage Journal Article PeerReviewed info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2015 ftunivzuerich https://doi.org/10.5167/uzh-11178810.1186/s12917-015-0471-0 2024-08-14T00:23:57Z BACKGROUND Canine distemper virus (CDV) is a major pathogen of dogs and wild carnivores worldwide. In Switzerland, distemper in domestic dogs is rarely reported. In recent years, the import of dogs from Eastern Europe to Switzerland has steadily increased. In the present study, we describe a distemper outbreak in 15 rescue dogs that were imported from Hungary to Switzerland by an animal welfare organisation. The data on vaccination and medical history were recorded (14 dogs), and the samples were collected to investigate CDV and vector-borne infections (13 dogs) and canine parvovirus infection (12 dogs). The dogs were monitored for six months. RESULTS One dog was euthanised directly after import. Thirteen dogs showed clinical signs after arrival, i.e., diarrhoea (57 %), coughing (43 %) and nasal and/or ocular discharge (21 %); radiographic findings that were compatible with bronchopneumonia were present in four dogs. CDV infection was diagnosed in 11 dogs (85 %); 10 dogs (91 %) tested PCR-positive in conjunctival swabs. Vector-borne infections (Babesia spp., Leishmania infantum, Dirofilaria immitis) were found in 4 dogs (31 %). Three dogs were hospitalized, and six dogs received ambulatory therapy for up to two months until recovery. None of the dogs developed neurological disease. CDV shedding was detected for a period of up to four months. Because dogs were put under strict quarantine until CDV shedding ceased, CDV did not spread to any other dogs. The CDV isolates showed 99 % sequence identity in the HA gene among each other and belonged to the Arctic-like lineage of CDV. CONCLUSIONS The present study highlights the imminent risks of spreading contagious viral and vector-borne infections through the non-selective import of sick dogs and dogs with incomplete vaccination from Eastern Europe. CDV shedding was detected for several months after the cessation of clinical signs, which emphasised the roles of asymptomatic carriers in CDV epidemiology. A long-term follow-up using sensitive PCR and strict quarantine ... Article in Journal/Newspaper Arctic University of Zurich (UZH): ZORA (Zurich Open Repository and Archive Arctic |
institution |
Open Polar |
collection |
University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
op_collection_id |
ftunivzuerich |
language |
English |
topic |
Institute of Parasitology Department of Farm Animals Department of Small Animals Department of Clinical Diagnostics and Services Center for Clinical Studies 570 Life sciences biology 630 Agriculture Canine distemper virus Outbreak Domestic dog Import Vector-borne infections Phylogenetic analysis Vaccination Arctic-like lineage |
spellingShingle |
Institute of Parasitology Department of Farm Animals Department of Small Animals Department of Clinical Diagnostics and Services Center for Clinical Studies 570 Life sciences biology 630 Agriculture Canine distemper virus Outbreak Domestic dog Import Vector-borne infections Phylogenetic analysis Vaccination Arctic-like lineage Willi, Barbara Spiri, Andrea M Meli, Marina L Grimm, Felix Beatrice, Laura Riond, Barbara Bley, T Jordi, R Dennler, Matthias Hofmann-Lehmann, Regina Clinical and molecular investigation of a canine distemper outbreak and vector-borne infections in a group of rescue dogs imported from Hungary to Switzerland |
topic_facet |
Institute of Parasitology Department of Farm Animals Department of Small Animals Department of Clinical Diagnostics and Services Center for Clinical Studies 570 Life sciences biology 630 Agriculture Canine distemper virus Outbreak Domestic dog Import Vector-borne infections Phylogenetic analysis Vaccination Arctic-like lineage |
description |
BACKGROUND Canine distemper virus (CDV) is a major pathogen of dogs and wild carnivores worldwide. In Switzerland, distemper in domestic dogs is rarely reported. In recent years, the import of dogs from Eastern Europe to Switzerland has steadily increased. In the present study, we describe a distemper outbreak in 15 rescue dogs that were imported from Hungary to Switzerland by an animal welfare organisation. The data on vaccination and medical history were recorded (14 dogs), and the samples were collected to investigate CDV and vector-borne infections (13 dogs) and canine parvovirus infection (12 dogs). The dogs were monitored for six months. RESULTS One dog was euthanised directly after import. Thirteen dogs showed clinical signs after arrival, i.e., diarrhoea (57 %), coughing (43 %) and nasal and/or ocular discharge (21 %); radiographic findings that were compatible with bronchopneumonia were present in four dogs. CDV infection was diagnosed in 11 dogs (85 %); 10 dogs (91 %) tested PCR-positive in conjunctival swabs. Vector-borne infections (Babesia spp., Leishmania infantum, Dirofilaria immitis) were found in 4 dogs (31 %). Three dogs were hospitalized, and six dogs received ambulatory therapy for up to two months until recovery. None of the dogs developed neurological disease. CDV shedding was detected for a period of up to four months. Because dogs were put under strict quarantine until CDV shedding ceased, CDV did not spread to any other dogs. The CDV isolates showed 99 % sequence identity in the HA gene among each other and belonged to the Arctic-like lineage of CDV. CONCLUSIONS The present study highlights the imminent risks of spreading contagious viral and vector-borne infections through the non-selective import of sick dogs and dogs with incomplete vaccination from Eastern Europe. CDV shedding was detected for several months after the cessation of clinical signs, which emphasised the roles of asymptomatic carriers in CDV epidemiology. A long-term follow-up using sensitive PCR and strict quarantine ... |
format |
Article in Journal/Newspaper |
author |
Willi, Barbara Spiri, Andrea M Meli, Marina L Grimm, Felix Beatrice, Laura Riond, Barbara Bley, T Jordi, R Dennler, Matthias Hofmann-Lehmann, Regina |
author_facet |
Willi, Barbara Spiri, Andrea M Meli, Marina L Grimm, Felix Beatrice, Laura Riond, Barbara Bley, T Jordi, R Dennler, Matthias Hofmann-Lehmann, Regina |
author_sort |
Willi, Barbara |
title |
Clinical and molecular investigation of a canine distemper outbreak and vector-borne infections in a group of rescue dogs imported from Hungary to Switzerland |
title_short |
Clinical and molecular investigation of a canine distemper outbreak and vector-borne infections in a group of rescue dogs imported from Hungary to Switzerland |
title_full |
Clinical and molecular investigation of a canine distemper outbreak and vector-borne infections in a group of rescue dogs imported from Hungary to Switzerland |
title_fullStr |
Clinical and molecular investigation of a canine distemper outbreak and vector-borne infections in a group of rescue dogs imported from Hungary to Switzerland |
title_full_unstemmed |
Clinical and molecular investigation of a canine distemper outbreak and vector-borne infections in a group of rescue dogs imported from Hungary to Switzerland |
title_sort |
clinical and molecular investigation of a canine distemper outbreak and vector-borne infections in a group of rescue dogs imported from hungary to switzerland |
publisher |
BioMed Central |
publishDate |
2015 |
url |
https://www.zora.uzh.ch/id/eprint/111788/ https://www.zora.uzh.ch/id/eprint/111788/1/Willi_BMC_Vet_Res_2015.pdf https://doi.org/10.5167/uzh-111788 https://doi.org/10.1186/s12917-015-0471-0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Willi, Barbara; Spiri, Andrea M; Meli, Marina L; Grimm, Felix; Beatrice, Laura; Riond, Barbara; Bley, T; Jordi, R; Dennler, Matthias; Hofmann-Lehmann, Regina (2015). Clinical and molecular investigation of a canine distemper outbreak and vector-borne infections in a group of rescue dogs imported from Hungary to Switzerland. BMC Veterinary Research, 11:154. |
op_relation |
https://www.zora.uzh.ch/id/eprint/111788/1/Willi_BMC_Vet_Res_2015.pdf doi:10.5167/uzh-111788 doi:10.1186/s12917-015-0471-0 info:pmid/26179635 urn:issn:1746-6148 |
op_rights |
info:eu-repo/semantics/openAccess Creative Commons: Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.5167/uzh-11178810.1186/s12917-015-0471-0 |
_version_ |
1809895184227368960 |