Retinal oxygen saturation is associated with HbA1c but not with short-term diabetes control, internal environment, smoking and mild retinopathy - ROXINEGLYD study
Purpose: Purpose of this prospective uncontrolled single-centre pilot study was to find an association of retinal oxygen saturation (SatO2) with acid–base balance (ABB), carboxyhaemoglobin concentration, current plasma glucose concentration (PG), mean PG and PG variability over the last 72 hr, haemo...
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2021
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ftunivzlinpubl:oai:publikace.k.utb.cz:10563/1010268 2023-07-16T03:59:13+02:00 Retinal oxygen saturation is associated with HbA1c but not with short-term diabetes control, internal environment, smoking and mild retinopathy - ROXINEGLYD study Mlčák, Petr Chlup, Rudolf Kudlová, Pavla Krystyník, Ondrej Král, Michal Kučerová, Veronika Spurná, Jaromira Titzová, Simona Hübnerová, Petra Vláčil, Ondrej Šínová, Irena Karhanová, Marta Zapletalová, Jana Šín, Martin 2021 http://publikace.k.utb.cz/handle/10563/1010268 en eng Blackwell Publishing Ltd https://onlinelibrary.wiley.com/doi/10.1111/aos.14853 Acta Ophthalmologica http://publikace.k.utb.cz/handle/10563/1010268 Acta Ophthalmologica acid-base balance carboxyhaemoglobin continuous glucose monitoring diabetes mellitus haemoglobin A1c retinal oximetry retinal vessel oxygen saturation article 2021 ftunivzlinpubl 2023-06-25T07:41:46Z Purpose: Purpose of this prospective uncontrolled single-centre pilot study was to find an association of retinal oxygen saturation (SatO2) with acid–base balance (ABB), carboxyhaemoglobin concentration, current plasma glucose concentration (PG), mean PG and PG variability over the last 72 hr, haemoglobin A1c (HbA1c), and other conditions. Methods: Forty-one adults (17 men) with type 1 (N = 14) or type 2 (N = 27) diabetes mellitus, age 48.6 ± 13.5 years, diabetes duration 9 (0.1–36) years, BMI 29.4 ± 6.3 kg/m2, and HbA1c 52 ± 12.7 mmol/mol completed the study. The 4-day study comprised two visits (Day l, Day 4) including 72 hr of continuous glucose monitoring (CGM) by iPro®2 Professional CGM (Medtronic, MiniMed, Inc., Northridge, CA, USA). Retinal oximeter Oxymap T1 (Oxymap ehf., Reykjavik, Iceland) was used to assess SatO2. Results: Wilcoxon signed-rank test showed no SatO2 difference between eyes and visits. Spearman's correlation analysis revealed a significant correlation between arterial SatO2 and PG variability in type 2 diabetes mellitus, a positive correlation of venous SatO2 with HbA1c and with finger pulse oximetry. However, no correlation of SatO2 with ABB, carboxyhaemoglobin, current PG, mean PG over the 72 hr, age, diabetes duration, BMI, lipoproteinaemia, body temperature, systolic and diastolic blood pressure, heart rate, central retinal thickness and retinal nerve fibre layer thickness was found. Conclusion: This study confirmed the association of venous SatO2 with long-term but not with short-term diabetes control, ABB and other conditions. The increased SatO2 and questionable impact of PG variability on retinal SatO2 is a research challenge. © 2021 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd Palacky University Olomouc [IGA_LF_2016_029] 2-s2.0-85102779045 Article in Journal/Newspaper Iceland Tomas Bata University Zlin: TBU publications |
institution |
Open Polar |
collection |
Tomas Bata University Zlin: TBU publications |
op_collection_id |
ftunivzlinpubl |
language |
English |
topic |
acid-base balance carboxyhaemoglobin continuous glucose monitoring diabetes mellitus haemoglobin A1c retinal oximetry retinal vessel oxygen saturation |
spellingShingle |
acid-base balance carboxyhaemoglobin continuous glucose monitoring diabetes mellitus haemoglobin A1c retinal oximetry retinal vessel oxygen saturation Mlčák, Petr Chlup, Rudolf Kudlová, Pavla Krystyník, Ondrej Král, Michal Kučerová, Veronika Spurná, Jaromira Titzová, Simona Hübnerová, Petra Vláčil, Ondrej Šínová, Irena Karhanová, Marta Zapletalová, Jana Šín, Martin Retinal oxygen saturation is associated with HbA1c but not with short-term diabetes control, internal environment, smoking and mild retinopathy - ROXINEGLYD study |
topic_facet |
acid-base balance carboxyhaemoglobin continuous glucose monitoring diabetes mellitus haemoglobin A1c retinal oximetry retinal vessel oxygen saturation |
description |
Purpose: Purpose of this prospective uncontrolled single-centre pilot study was to find an association of retinal oxygen saturation (SatO2) with acid–base balance (ABB), carboxyhaemoglobin concentration, current plasma glucose concentration (PG), mean PG and PG variability over the last 72 hr, haemoglobin A1c (HbA1c), and other conditions. Methods: Forty-one adults (17 men) with type 1 (N = 14) or type 2 (N = 27) diabetes mellitus, age 48.6 ± 13.5 years, diabetes duration 9 (0.1–36) years, BMI 29.4 ± 6.3 kg/m2, and HbA1c 52 ± 12.7 mmol/mol completed the study. The 4-day study comprised two visits (Day l, Day 4) including 72 hr of continuous glucose monitoring (CGM) by iPro®2 Professional CGM (Medtronic, MiniMed, Inc., Northridge, CA, USA). Retinal oximeter Oxymap T1 (Oxymap ehf., Reykjavik, Iceland) was used to assess SatO2. Results: Wilcoxon signed-rank test showed no SatO2 difference between eyes and visits. Spearman's correlation analysis revealed a significant correlation between arterial SatO2 and PG variability in type 2 diabetes mellitus, a positive correlation of venous SatO2 with HbA1c and with finger pulse oximetry. However, no correlation of SatO2 with ABB, carboxyhaemoglobin, current PG, mean PG over the 72 hr, age, diabetes duration, BMI, lipoproteinaemia, body temperature, systolic and diastolic blood pressure, heart rate, central retinal thickness and retinal nerve fibre layer thickness was found. Conclusion: This study confirmed the association of venous SatO2 with long-term but not with short-term diabetes control, ABB and other conditions. The increased SatO2 and questionable impact of PG variability on retinal SatO2 is a research challenge. © 2021 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd Palacky University Olomouc [IGA_LF_2016_029] 2-s2.0-85102779045 |
format |
Article in Journal/Newspaper |
author |
Mlčák, Petr Chlup, Rudolf Kudlová, Pavla Krystyník, Ondrej Král, Michal Kučerová, Veronika Spurná, Jaromira Titzová, Simona Hübnerová, Petra Vláčil, Ondrej Šínová, Irena Karhanová, Marta Zapletalová, Jana Šín, Martin |
author_facet |
Mlčák, Petr Chlup, Rudolf Kudlová, Pavla Krystyník, Ondrej Král, Michal Kučerová, Veronika Spurná, Jaromira Titzová, Simona Hübnerová, Petra Vláčil, Ondrej Šínová, Irena Karhanová, Marta Zapletalová, Jana Šín, Martin |
author_sort |
Mlčák, Petr |
title |
Retinal oxygen saturation is associated with HbA1c but not with short-term diabetes control, internal environment, smoking and mild retinopathy - ROXINEGLYD study |
title_short |
Retinal oxygen saturation is associated with HbA1c but not with short-term diabetes control, internal environment, smoking and mild retinopathy - ROXINEGLYD study |
title_full |
Retinal oxygen saturation is associated with HbA1c but not with short-term diabetes control, internal environment, smoking and mild retinopathy - ROXINEGLYD study |
title_fullStr |
Retinal oxygen saturation is associated with HbA1c but not with short-term diabetes control, internal environment, smoking and mild retinopathy - ROXINEGLYD study |
title_full_unstemmed |
Retinal oxygen saturation is associated with HbA1c but not with short-term diabetes control, internal environment, smoking and mild retinopathy - ROXINEGLYD study |
title_sort |
retinal oxygen saturation is associated with hba1c but not with short-term diabetes control, internal environment, smoking and mild retinopathy - roxineglyd study |
publisher |
Blackwell Publishing Ltd |
publishDate |
2021 |
url |
http://publikace.k.utb.cz/handle/10563/1010268 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Acta Ophthalmologica |
op_relation |
https://onlinelibrary.wiley.com/doi/10.1111/aos.14853 Acta Ophthalmologica http://publikace.k.utb.cz/handle/10563/1010268 |
_version_ |
1771546790968950784 |