Epithelial–Mesenchymal Transition in a Case of Metastatic Thyroid Carcinoma in a Brown Bear (Ursus arctos)
A 20-year-old male brown bear (Ursus arctos) with a 20 × 25 cm necrotic mass adjacent to the trachea was diagnosed as having an anaplastic thyroid carcinoma. Metastases were observed in the lungs and one adrenal gland and, histologically, these had anaplastic and follicular carcinoma patterns, respe...
Published in: | Journal of Comparative Pathology |
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Online Access: | http://zaguan.unizar.es/record/99361 https://doi.org/10.1016/j.jcpa.2020.01.004 |
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ftunivzaraaneto:oai:zaguan.unizar.es:99361 2023-05-15T18:41:48+02:00 Epithelial–Mesenchymal Transition in a Case of Metastatic Thyroid Carcinoma in a Brown Bear (Ursus arctos) Rodríguez-Largo, A. de Miguel, R. Asín, J. Chocteau, F. Gimeno, M. Pinczowski, P. de Martino, A. Luján, L. 2020 application/pdf http://zaguan.unizar.es/record/99361 https://doi.org/10.1016/j.jcpa.2020.01.004 eng eng http://zaguan.unizar.es/record/99361 doi:10.1016/j.jcpa.2020.01.004 by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ CC-BY-NC-ND info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion 2020 ftunivzaraaneto https://doi.org/10.1016/j.jcpa.2020.01.004 2022-03-10T16:38:44Z A 20-year-old male brown bear (Ursus arctos) with a 20 × 25 cm necrotic mass adjacent to the trachea was diagnosed as having an anaplastic thyroid carcinoma. Metastases were observed in the lungs and one adrenal gland and, histologically, these had anaplastic and follicular carcinoma patterns, respectively. E-cadherin labelling was observed in the adrenal mass only, while N-cadherin immunolabelling was detected in the thyroid gland and lung masses. Thyroid-specific markers (thyroid transcription factor-1, thyroglobulin) were expressed in the adrenal gland metastasis. This case illustrates an example of a primary epithelial–mesenchymal transition (EMT) enabling metastasis to distant organ sites, followed by a mesenchymal–epithelial transition within the adrenal gland microenvironment, allowing invasion and reacquisition of thyroid epithelial cell features. EMTs help to understand the phenomenon of carcinoma cell plasticity in enabling colonization and growth of metastases. Article in Journal/Newspaper Ursus arctos Digital Repository of University of Zaragoza (ZAGUAN) Journal of Comparative Pathology 176 10 13 |
institution |
Open Polar |
collection |
Digital Repository of University of Zaragoza (ZAGUAN) |
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ftunivzaraaneto |
language |
English |
description |
A 20-year-old male brown bear (Ursus arctos) with a 20 × 25 cm necrotic mass adjacent to the trachea was diagnosed as having an anaplastic thyroid carcinoma. Metastases were observed in the lungs and one adrenal gland and, histologically, these had anaplastic and follicular carcinoma patterns, respectively. E-cadherin labelling was observed in the adrenal mass only, while N-cadherin immunolabelling was detected in the thyroid gland and lung masses. Thyroid-specific markers (thyroid transcription factor-1, thyroglobulin) were expressed in the adrenal gland metastasis. This case illustrates an example of a primary epithelial–mesenchymal transition (EMT) enabling metastasis to distant organ sites, followed by a mesenchymal–epithelial transition within the adrenal gland microenvironment, allowing invasion and reacquisition of thyroid epithelial cell features. EMTs help to understand the phenomenon of carcinoma cell plasticity in enabling colonization and growth of metastases. |
format |
Article in Journal/Newspaper |
author |
Rodríguez-Largo, A. de Miguel, R. Asín, J. Chocteau, F. Gimeno, M. Pinczowski, P. de Martino, A. Luján, L. |
spellingShingle |
Rodríguez-Largo, A. de Miguel, R. Asín, J. Chocteau, F. Gimeno, M. Pinczowski, P. de Martino, A. Luján, L. Epithelial–Mesenchymal Transition in a Case of Metastatic Thyroid Carcinoma in a Brown Bear (Ursus arctos) |
author_facet |
Rodríguez-Largo, A. de Miguel, R. Asín, J. Chocteau, F. Gimeno, M. Pinczowski, P. de Martino, A. Luján, L. |
author_sort |
Rodríguez-Largo, A. |
title |
Epithelial–Mesenchymal Transition in a Case of Metastatic Thyroid Carcinoma in a Brown Bear (Ursus arctos) |
title_short |
Epithelial–Mesenchymal Transition in a Case of Metastatic Thyroid Carcinoma in a Brown Bear (Ursus arctos) |
title_full |
Epithelial–Mesenchymal Transition in a Case of Metastatic Thyroid Carcinoma in a Brown Bear (Ursus arctos) |
title_fullStr |
Epithelial–Mesenchymal Transition in a Case of Metastatic Thyroid Carcinoma in a Brown Bear (Ursus arctos) |
title_full_unstemmed |
Epithelial–Mesenchymal Transition in a Case of Metastatic Thyroid Carcinoma in a Brown Bear (Ursus arctos) |
title_sort |
epithelial–mesenchymal transition in a case of metastatic thyroid carcinoma in a brown bear (ursus arctos) |
publishDate |
2020 |
url |
http://zaguan.unizar.es/record/99361 https://doi.org/10.1016/j.jcpa.2020.01.004 |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_relation |
http://zaguan.unizar.es/record/99361 doi:10.1016/j.jcpa.2020.01.004 |
op_rights |
by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1016/j.jcpa.2020.01.004 |
container_title |
Journal of Comparative Pathology |
container_volume |
176 |
container_start_page |
10 |
op_container_end_page |
13 |
_version_ |
1766231359824592896 |